A5047663236- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Zebrafish Biomedical Research Applications
- Mitochondrial Function and Pathology
- Neurogenesis and neuroplasticity mechanisms
- Developmental Biology and Gene Regulation
- Pluripotent Stem Cells Research
- Anesthesia and Neurotoxicity Research
- Neurotransmitter Receptor Influence on Behavior
- Animal Behavior and Reproduction
- Axon Guidance and Neuronal Signaling
- Neurobiology and Insect Physiology Research
- Nerve injury and regeneration
- Receptor Mechanisms and Signaling
- Sleep and Wakefulness Research
- Invertebrate Immune Response Mechanisms
- Neural dynamics and brain function
University of New Mexico
2015-2021
University of Colorado Anschutz Medical Campus
2017-2021
University of Colorado Denver
2018-2019
The Medical Center of Aurora
2019
During morphogenesis, cells communicate with each other to shape tissues and organs. Several lines of recent evidence indicate that ion channels play a key role in cellular signaling tissue morphogenesis. However, little is known about the scope specific ion-channel types impinge upon developmental pathways. The Drosophila melanogaster wing an excellent model which address this problem as vein patterning acutely sensitive changes We conducted screen 180 expressed using loss-of-function...
Abstract Activity in numerous brain regions drives heroin seeking, but no circuits that limit seeking have been identified. Furthermore, the neural controlling opioid choice are unknown. In this study, we examined role of infralimbic cortex (IL) to nucleus accumbens shell (NAshell) pathway during and relapse. This model yielded subpopulations versus food preferring rats choice, was unrelated subsequent relapse rates cues, suggesting distinct behavioral constructs. Supporting this,...
The ability to attend appropriate stimuli, plan actions and then alter those when environmental conditions change, is essential for an organism thrive. There increasing evidence that these executive control processes are mediated in part by N-methyl-D-aspartate receptors (NMDAR). NMDAR subunits confer different physiological properties the receptor, interact with distinct intracellular postsynaptic scaffolding signaling molecules differentially expressed during development. Recent findings...
Zebrafish, first introduced as a developmental model, have gained popularity in many other fields. The ease of rearing large numbers rapidly developing organisms, combined with the embryonic optical clarity, served initial compelling attributes this model. Over past two decades, success model has been further propelled by its amenability to large-scale mutagenesis screens and transgenesis. More recently, gene-editing approaches extended power For neurodevelopmental studies, zebrafish embryo...
Movement requires effective relay of commands from the CNS to muscles at neuromuscular junctions (NMJs). To form NMJs, developing motor neuron axons exit spinal cord and navigate through a complex landscape align with prepatterned AChRs on target muscle fibers ([Yang et al., 2001][1]).