A5030098185- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Plant Reproductive Biology
- Multiple Myeloma Research and Treatments
- Epigenetics and DNA Methylation
- Plant Molecular Biology Research
- Long-Term Effects of COVID-19
- Cancer-related gene regulation
- Genetic Neurodegenerative Diseases
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Spinal Fractures and Fixation Techniques
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Nanoparticle-Based Drug Delivery
- Spine and Intervertebral Disc Pathology
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
- Metabolism, Diabetes, and Cancer
- Ubiquitin and proteasome pathways
- Scoliosis diagnosis and treatment
- Spinal Dysraphism and Malformations
- Enhanced Recovery After Surgery
- Plant nutrient uptake and metabolism
- Acute Myeloid Leukemia Research
- Cancer-related Molecular Pathways
Princess Margaret Cancer Centre
2023-2025
University Health Network
2023-2025
Hebei Normal University
2024
Fraser Health
2021-2024
First Affiliated Hospital of Wannan Medical College
2024
Wannan Medical College
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Guang’anmen Hospital
2024
Structural Genomics Consortium
2020-2022
University of Toronto
2020-2022
Abstract Triple negative breast cancer (TNBC) is a deadly form of due to the development resistance chemotherapy affecting over 30% patients. New therapeutics and companion biomarkers are urgently needed. Recognizing elevated expression glucose transporter 1 (GLUT1, encoded by SLC2A1 ) associated metabolic dependencies in TNBC, we investigated vulnerability TNBC cell lines patient-derived samples GLUT1 inhibition. We report that genetic or pharmacological inhibition with BAY-876 impairs...
Abstract Triple-negative breast cancer (TNBC) is the most aggressive subtype with worst prognosis and few effective therapies. Here we identified MS023, an inhibitor of type I protein arginine methyltransferases (PRMTs), which has antitumor growth activity in TNBC. Pathway analysis TNBC cell lines indicates that activation interferon responses before after MS023 treatment a functional biomarker determinant response, these observations extend to panel human-derived organoids. Inhibition PRMT...
Abstract RNA interference is a powerful research tool for studying gene function in cancer cells. However, functional genomic studies Acute Myeloid Leukemia (AML) remain challenging. Classic lipid-based transfection reagents are ineffective delivering siRNA to AML cells and lentiviral delivery of shRNA complex time-consuming. Lipid Nanoparticles (LNPs) novel approach deliver genetic material that difficult transfect. formulation LNP capable transfecting primary samples with high efficiency...
Abstract Almost all mitochondrial proteins are encoded by nuclear DNA, translated in the cytosol, and imported into mitochondria. Once inside mitochondria, these unfolded, aggregation prone precursors processed folded mature forms. Failure to properly process fold newly results formation of toxic aggregates. To counter stress from proteins, cells developed unfolded protein response (UPRmt), a conserved pathway which activates transcription proteases chaperones degrade There no UPRmt gene...
Abstract IL-23 receptor (IL-23R) is canonically a T cell surface cytokine known for its role in inflammatory diseases. In this study, we demonstrated that IL-23R localizes intracellularly AML where it regulates mitotic spindle formation. Differential gene expressions were analyzed samples compared to normal controls. Of the upregulated processes, ontology was most enriched. Analyzing all protein coding genes their correlation surprisingly returned as top hit. We confirmed expression 7 of...
Abstract: Novel gadolinium-loaded liposomes guided by GBI-10 aptamer were developed and evaluated in vitro to enhance magnetic resonance imaging (MRI) diagnosis of tumor. Nontargeted achieved incorporating amphipathic material, Gd (III) [ N , -bis-stearylamidomethyl- '-amidomethyl] diethylenetriamine tetraacetic acid, into the liposome membrane using lipid film hydration method. GBI-10, as targeting ligand, was then conjugated onto surface get GBI-10-targeted (GTLs). Both nontargeted GTLs...
Receptor kinases DRUS1 (Dwarf and Runtish Spikelet1) DRUS2 are orthologues of the renowned Arabidopsis thaliana gene FERONIA, which play redundant roles in rice growth development. Whether two duplicated genes perform distinct functions response to environmental stress is largely unknown. Here, we found that osmotic (OS) ABA increased expression while decreasing DRUS2. When subjected stress, drus2 mutants suppresses OsIAA repressors, resulting a robust root system with an number adventitious...
Abstract Compared to normal hematopoietic cells, AML cells exhibit a heightened reliance on mitochondrial metabolism for survival and proliferation. To support this unique phenotype, increase import of nuclear-encoded proteins which must be properly folded by chaperones, proteases, heat shock proteins. Failure fold these precursors leads protein aggregation, dysfunction, cell death. evaluate the maintaining proteostasis, we assessed gene dependency datasets (eg: depmap.org) identified...
Background/Objectives: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a neurological disorder characterized by post-exertional malaise. Despite its clinical relevance, the disease mechanisms of ME/CFS are not fully understood. The previous studies targeting brain function or metabolites have been inconclusive in understanding complexity. We combined single-voxel magnetic resonance spectroscopy (SV-MRS) and functional imaging (fMRI). Our objectives were to examine feasibility...
To investigate the role of plasma circulating cell-free DNA (cf-DNA) in screening and diagnosis patients with newly diagnosed multiple myeloma (MM) explore changes cf-DNA terms content integrality assessment disease treated chemotherapy.
To investigate the safety, efficacy, and prognosis of high-dose melphalan in combination with autologous hematopoietic stem cell transplantation (ASCT) for treatment multiple myeloma (MM).
Abstract Triple negative breast cancer (TNBC) is the most aggressive subtype with worst prognosis and few effective therapies. Here, we undertook a screen of epigenetic chemical probes to systematically uncover regulators critical for TNBC growth. We identified MS023, an inhibitor type I protein arginine methyltransferases (PRMTs), as having anti-tumor growth activity in vitro vivo. Pathway analysis cell lines indicates that activation interferon responses pre- post-MS023 treatment...