A5022508565- Sarcoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Cell Adhesion Molecules Research
- Multiple Myeloma Research and Treatments
- Ubiquitin and proteasome pathways
- Developmental Biology and Gene Regulation
- 14-3-3 protein interactions
- Cancer, Lipids, and Metabolism
- Hedgehog Signaling Pathway Studies
- Protease and Inhibitor Mechanisms
- Melanoma and MAPK Pathways
- Lymphoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Sex work and related issues
- RNA Research and Splicing
- RNA modifications and cancer
- Adolescent Sexual and Reproductive Health
- Oral and Maxillofacial Pathology
- Angiogenesis and VEGF in Cancer
- Intimate Partner and Family Violence
University of Virginia
2016-2018
Boston Children's Hospital
2013
Columbia University Irving Medical Center
2013
Massachusetts Institute of Technology
2013
Massachusetts General Hospital
2013
Broad Institute
2013
Dana-Farber Cancer Institute
2013
Limited progress has been made in the treatment of advanced-stage pediatric solid tumors despite accelerated pace cancer discovery over last decade. Tyrosine kinase inhibition is one tractable therapeutic modality for treating human malignancy. However, little known about kinases critical to development or maintenance many such as Ewing sarcoma. Using a fluorescent, bead-based technology profile activated tyrosine kinases, we identified focal adhesion (FAK, PTK2) candidate target FAK...
Rates of many sexually transmitted diseases remain higher among adolescents than any other age group. The associations between abuse experiences and risky sexual behaviors suggest that exploring the relationships adolescents' history condom use beliefs is warranted. Females (N = 725) attending an adolescent clinic reported demographic characteristics, about use, behaviors, or molestation history. Those reporting (23%) were more likely to think condoms interfered with pleasure less important...
<div>Abstract<p>Limited progress has been made in the treatment of advanced-stage pediatric solid tumors despite accelerated pace cancer discovery over last decade. Tyrosine kinase inhibition is one tractable therapeutic modality for treating human malignancy. However, little known about kinases critical to development or maintenance many such as Ewing sarcoma. Using a fluorescent, bead-based technology profile activated tyrosine kinases, we identified focal adhesion (FAK, PTK2)...
<p>PDF file - 62K, Treatment of two Ewing sarcoma cell lines with A, dasatinib (SRC inhibitor) for 8 hours or B, PD0325901 (MEK 72 eliminates phosphorylation SRC and ERK, respectively (S1); Transduction five FAK-directed shRNAs downregulate FAK expression compared to a control shRNA in the A673 line (S2); TC32 PF-562271 reduced growth (S3); PF- 562271 impairs (S4); PYK2 is variably expressed (S5).</p>
<p>PDF file - 17K</p>
<p>PDF file - 62K, Treatment of two Ewing sarcoma cell lines with A, dasatinib (SRC inhibitor) for 8 hours or B, PD0325901 (MEK 72 eliminates phosphorylation SRC and ERK, respectively (S1); Transduction five FAK-directed shRNAs downregulate FAK expression compared to a control shRNA in the A673 line (S2); TC32 PF-562271 reduced growth (S3); PF- 562271 impairs (S4); PYK2 is variably expressed (S5).</p>
<p>PDF file - 17K</p>
<div>Abstract<p>Limited progress has been made in the treatment of advanced-stage pediatric solid tumors despite accelerated pace cancer discovery over last decade. Tyrosine kinase inhibition is one tractable therapeutic modality for treating human malignancy. However, little known about kinases critical to development or maintenance many such as Ewing sarcoma. Using a fluorescent, bead-based technology profile activated tyrosine kinases, we identified focal adhesion (FAK, PTK2)...
Abstract Aberrant activation of tyrosine kinases is a frequent driver event in cancer. Nevertheless, for many tumors, the critical kinase abnormalities have yet to be discovered. Emerging technologies are enabling rapid profiling high-throughput format not only expression, but activation. We leveraged bead-based approach phosphorylation Ewing sarcoma and identified focal adhesion (FAK) as top candidate. second most common bone tumor diagnosed children. Current treatment de novo disease...