A5020688140- Immune Cell Function and Interaction
- Immune cells in cancer
- Bone Metabolism and Diseases
- Phagocytosis and Immune Regulation
- Atherosclerosis and Cardiovascular Diseases
- Cholesterol and Lipid Metabolism
- Erythrocyte Function and Pathophysiology
- Cytomegalovirus and herpesvirus research
- Neonatal Health and Biochemistry
- Cell Adhesion Molecules Research
- Immunodeficiency and Autoimmune Disorders
- Radiopharmaceutical Chemistry and Applications
- Bone and Joint Diseases
- Heme Oxygenase-1 and Carbon Monoxide
Soochow University
2022-2024
Background: ABCA1 (ATP-binding cassette transporter A1) mediates cholesterol efflux to apo AI maintain cellular homeostasis. The current study aims investigate whether T-cell–specific deletion of modulates the phenotype/function T cells and development atherosclerosis. Methods: Mice with on low-density lipoprotein receptor knockout ( Ldlr −/− ) background Abca1 CD4-/CD4- were generated by multiple steps (cross)-breedings among flox/flox , CD4- Cre mice. Results: Deletions greatly suppressed...
Rheumatoid arthritis (RA) is a chronic autoimmune disease accompanied by local and systemic bone loss. FcγRs, especially FcγRIIa (hFcγRIIa), have been implicated in the pathogenesis of RA. However, contribution hFcγRIIa to loss has not fully elucidated. In present study, we demonstrated double-edged sword role on osteoclast differentiation through investigations involving hFcγRIIa-transgenic (hFcγRIIa-Tg) mice. Our findings reveal that hFcγRIIa-Tg mice, previously shown exhibit heightened...
Objective Rheumatoid arthritis is an autoimmune disease characterized by synovial inflammation-driven cartilage and bone destruction, a process mainly mediated osteoclasts. In recent years M2-like macrophages have been found to play important role in the pathological of RA mediating pro-inflammatory effects, but their roles destruction not reported. Methods Results this study we identified that abundant cell population CD45 + CD11b Gr-1 - F4/80 CD206 cells, which were normally classified as...
Calreticulin (CRT) is a major calcium-binding luminal resident protein on the endoplasmic reticulum that can also be released extracellular as well anchored surface of cells. Previously, we demonstrated soluble recombinant CRT fragment 39-272 (CRT/39-272) exhibited potent immunostimulatory effects immunoregulation immune Here, constructed stable B16 melanoma cell lines expressing CRT/39-272 membrane (B16-tmCRT/39-272) to investigate roles tumor progression. We found B16-tmCRT/39-272 cells...
ABSTRACT Loss-of-function mutations of ZBTB24 cause the Immunodeficiency, Centromeric Instability and Facial Anomalies syndrome 2 (ICF2). ICF2 is a rare autosomal recessive disorder with immunological defects in serum antibodies circulating memory B cells, indicating an essential role terminal differentiation cells. Here we generated B-cell specific Zbtb24-deficient mice systemically investigated its cell development function both vivo vitro . Zbtb24 dispensable for & maintenance naive...