A5017688841- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Psoriasis: Treatment and Pathogenesis
- Cytokine Signaling Pathways and Interactions
- IL-33, ST2, and ILC Pathways
- Bioinformatics and Genomic Networks
- Genetic Associations and Epidemiology
- Inflammatory Bowel Disease
- Food Allergy and Anaphylaxis Research
- Exercise and Physiological Responses
- Pharmacogenetics and Drug Metabolism
- Vitamin D Research Studies
- Immune cells in cancer
- Inflammasome and immune disorders
- Pharmaceutical and Antibiotic Environmental Impacts
- Analytical chemistry methods development
- Immunotherapy and Immune Responses
- Allergic Rhinitis and Sensitization
- Systemic Lupus Erythematosus Research
- Genomics and Chromatin Dynamics
- Monoclonal and Polyclonal Antibodies Research
- NF-κB Signaling Pathways
- Contact Dermatitis and Allergies
- Genomics, phytochemicals, and oxidative stress
- Biochemical and Molecular Research
University of Patras
2021-2025
Due to its ubiquitous presence in the environment and lack of a scientific consensus regarding environmental safety widely used anionic surfactant Sodium Lauryl Sulfate (CAS No: 151-21-3), systematic literature review thematic analysis was conducted. All studies about sodium lauryl sulfate (SLS) key databases were reviewed, with coding methods identify impact categories from SLS exposure without potential narration bias. Based on limited number SLS, there is empirical evidence this...
Background: Incorporation of gene expression when estimating polygenic risk scores (PRS) in atopic dermatitis (AD) may provide additional insights disease pathogenesis and enhance predictive accuracy. Objective: In this study, we developed transcriptome (PTRSs) derived from AD-enriched tissues evaluated their performance against traditional PRS models a baseline model incorporating eosinophil lymphocyte counts the prediction AD. Methods: We conducted transcriptome-wide association studies...
Abstract Background Incorporation of gene expression when estimating polygenic risk scores (PRS) in atopic dermatitis (AD) may provide additional insights disease pathogenesis and enhance predictive accuracy. In this study, we developed transcriptome (PTRSs) derived from AD-enriched tissues evaluated their performance against traditional PRS models a baseline model incorporating eosinophil lymphocyte counts the prediction AD. Methods We conducted transcriptome-wide association studies (TWAS)...
The clinical heterogeneity regarding the response profile of antitumor necrosis factor (anti-TNF) in patients with Crohn's disease (CD) and psoriasis (PsO) is attributed, amongst others, to genetic factors that influence regulatory mechanisms which orchestrate inflammatory response. Here, we investigated possible associations between MIR146A rs2910164 MIR155 rs767649 variants anti-TNF therapy a Greek cohort 103 CD 100 PsO patients. We genotyped via PCR-RFLP method, utilizing de novo...
This study explores the potential of gene polymorphisms in canonical and noncanonical NF-kB signaling pathway as a prediction biomarker anti-tumor necrosis factor (TNF)α response Crohn's patients.A total 109 Greek patients with disease (CD) were recruited, genotype TLR2 rs3804099, LTA rs909253, TLR4 rs5030728, MAP3K14/NIK rs7222094 single nucleotide was investigated for association to anti-TNFα therapy. Patient's therapy based on Disease Activity Index, depicting maximum within 24 months...
With the advent of next-generation sequencing (NGS), experimental techniques that capture biological significance DNA loci or RNA molecules have emerged as fundamental tools for studying epigenome and transcriptional regulation on a genome-wide scale. The volume generated data underlying complexity regarding their analysis highlight need robust easy-to-use computational analytic methods can streamline process provide valuable insights. Our solution, aPEAch, is an automated pipeline...
Abstract Comorbidities between atopic dermatitis (AD) and neuropsychiatric disorders are frequently reported, however the extent of shared genetic architecture remains unclear. Here, we performed a large-scale genome-wide pleiotropy approach to investigate correlations causal associations AD five disorders, attention deficit hyperactivity disorder (ADHD), autism spectrum (ASD), bipolar (BP), major depressive (MDD), schizophrenia (SCZ). Using association (GWAS) data, explored overlaps,...
Introduction Polygenic Risk Scores (PRS) are an emerging tool for predicting individual’s genetic risk to a complex trait. Several methods have been proposed construct and calculate these scores. Here, we develop biologically driven PRS using the UK BioBank cohort through validated protein interactions (PPI) network construction psoriasis, incorporating variants mapped interacting genes of 14 psoriasis susceptibility (PSORS) loci, as identified from previous linkage studies. Methods We...
Genome-wide association studies (GWASs) for atopic dermatitis (AD) have uncovered 81 risk loci in European participants, however translating these findings into functional and therapeutic insights remains challenging. We conducted a transcriptome-wide study (TWAS) AD leveraging cis-eQTL data from 3 central tissues the latest GWAS of Europeans. implemented OTTERS pipeline that combines polygenic score (PRS) techniques accommodating diverse assumptions architecture gene regulation. also used...
Abstract Despite the abundance of epidemiological evidence for high comorbid rate between psoriasis and obesity, systematic approaches on common inflammatory mechanisms have not been adequately explored. We performed a meta-analysis publicly available RNA-sequencing datasets to unveil putative that are postulated exacerbate both diseases, utilizing late-stage, disease-specific meta-analyses consensus gene co-expression network (cWGCNA). Single-gene reported several fostered by perturbed...
Abstract Background Polygenic Risk Scores (PRS) have been widely applied for predicting an individual’s genetic risk to a phenotype. Here, we develop biologically-driven PRS in the UK BioBank cohort through validated protein interactions (PPI) and network construction psoriasis, incorporating variants mapped interacting genes. We compare our PPI-PRS approach conventional calculations liberal P -value thresholds. Results show that novel provides similar results methods, despite incorporation...