A5031238975- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Banking stability, regulation, efficiency
- Olfactory and Sensory Function Studies
- Translation Studies and Practices
- Regional Economic and Spatial Analysis
- Metastasis and carcinoma case studies
- Genetic factors in colorectal cancer
- Gastrointestinal motility and disorders
- Gastric Cancer Management and Outcomes
- linguistics and terminology studies
- Interpreting and Communication in Healthcare
- Migration, Health and Trauma
- Motivation and Self-Concept in Sports
- Music Therapy and Health
- Ubiquitin and proteasome pathways
- Intestinal and Peritoneal Adhesions
- Cancer survivorship and care
- BRCA gene mutations in cancer
- Global Financial Crisis and Policies
- Heart Failure Treatment and Management
Hangzhou Normal University
2025
Sichuan Provincial Hospital of Traditional Chinese Medicine
2025
University of Minnesota
2020-2024
Case Western Reserve University
2024
Hormel (United States)
2020-2024
University of Minnesota System
2022
Jilin University
2015-2020
First Hospital of Jilin University
2015-2019
Shanghai University of Sport
2019
First Bethune Hospital of Jilin University
2018
As a DNA repair protein, Flap endonuclease 1 (FEN1) plays crucial parts in preventing carcinogenesis. Two functional germ line variants (–69G > A and 4150G T) the FEN1 gene have been associated with damage levels coke oven workers lung cancer risk general populations. However, role of these genetic on gastrointestinal susceptibility is unknown. Therefore, we evaluated association between polymorphisms two independent case–control cohorts consisted total 1850 (hepatocellular carcinoma,...
As a tumor suppressor, breast cancer susceptibility gene 1 ( BRCA1 ) plays pivotal role in maintaining genomic stability. A functional rs799917 T>C polymorphism located the coding sequence could influence miR-638-mediated regulation of expression. Therefore, we examined association between this and esophageal squamous cell carcinoma (ESCC) risk as well its biological function. Genotypes were determined two independent case–control studies consisted 1128 ESCC patients 1150 controls. Odds...
<title>Abstract</title> <bold>Objectives: </bold>This study aimed to compare the temporal trends in age and gender burdens of low back pain (LBP) China global from 1990 2021, including incidence, prevalence, disability-adjusted life years (DALYs), predict burden LBP next 15 years. <bold>Methods: </bold>Using open data Global Burden Disease (GBD) database this analyzed characteristics globally, changes DALYs. The average annual percentage change (AAPC) corresponding 95% confidence intervals...
Abstract Background Resistance to targeted therapies represents a significant hurdle successfully treating hepatocellular carcinoma (HCC). While epigenetic abnormalities are critical determinants of HCC relapse and therapeutic resistance, the underlying mechanisms poorly understood. We aimed address whether how dysregulated regulators have regulatory functional communications in establishing maintaining drug resistance. Methods HCC-resistant cells were characterized by CCK-8, IncuCyte...
Small ubiquitin‑like modifier proteins are involved in tumorigenesis; however, the potential effects and functions of family member modifier‑activating enzyme 2 (UBA2) on colorectal cancer not clear. The present study aimed to examine UBA2 proliferation cells vitro vivo. mRNA protein expression levels patients with were measured by reverse transcription‑quantitative polymerase chain reaction immunohistochemistry, respectively. tissues significantly increased compared paracancerous normal...
Aim: To build a prognostic nomogram based on log odds of positive lymph nodes for patients with gastric carcinoma (GC) after resection, and to compare the predictive performance American Joint Committee Cancer (AJCC) staging system node ratio (LNR). Methods: Multivariate analyses were performed identify independent variables cancer-specific survival (CSS). A was constructed clinicopathological factors. Results: The C-indices predicting CSS 0.674 in development cohort 0.647 validation cohort,...
Financial networks, creating potential propagation channels for shocks in crises, are widely viewed as a key factor to systemic stability. In this paper, we develop dynamic model of deleveraging an overlapping network assets. We study the spirals driven by interaction between fire sales and confidence effects, show how distress is amplified propagated throughout network. Using regulatory data from Peoples Bank China (PBC), construct assets then apply system. The result suggests that: (1)...
Rationale: The synchronous occurrence of lung cancer in patients with gastric neoplasms is relatively uncommon, especially the cases coexistence small cell carcinoma and diffuse large B-cell lymphoma stomach. Patient concerns: We encountered a case primary A 63-year-old patient 7.5 × 5.09 cm mass superior lobe right diagnosed Diagnoses: diseases were by pathological biopsy immunohistochemical methods. Interventions: As received CHOP chemotherapy, pulmonary function deterioraed. Etoposide was...
Objective . To evaluate the in vivo therapeutic effects of attenuated Salmonella carrying PCDNA3.1-ER β plasmid hormone-independent prostatic cancer nude mice and to clarify mechanism by which estrogen receptor (ER ) induces apoptosis proliferation cells mice. Methods The orthotopic models were randomly divided as follows: MOCK group, treated with PBS, PQ alone, PQ-PCDNA3.1 PCDNA3.1 plasmid, PQ-PCDNA3.1-ER plasmid. Then, 10 μ l plasmid-containing solution, comprising 1 × 7 cfu bacteria, was...
The purpose of this study was to describe the challenge cross-cultural care encounters from perspective imported nurses in Lhasa, Tibet, as well investigate relationship and its influencing factors.A cross-sectional survey designed among 300 255 patients selected four comprehensive hospitals (including two Grade III Class A B hospitals) Lhasa. average number, standard deviations, constituent ratios, T-tests, rank-sum tests, one-way ANOVAs, multiple stepwise regression analyses, Pearson...
Abstract Disease recurrence characterized by drug resistance remains a major hurdle to the successful cancer treatment. Long noncoding RNAs (lncRNAs) and RNA N⁶-methyladenosine (m6A) have been linked recurrence. However, if how lncRNAs m6A coordinately determine in tyrosine kinase (TK)-driven cancers are still unclear. We hypothesize that upon exposure TK inhibitors (TKI), dynamic methylation epitransciptomically allows set of proliferation/anti-apoptosis-relevant bearing motifs be rapidly...
Abstract Background Resistance to targeted therapies represents a major hurdle successfully treat hepatocellular carcinoma (HCC). While epigenetic abnormalities are critical determinants of HCC relapse and therapeutic resistance, the underlying mechanisms poorly understood. We aimed address whether how dysregulated regulators have regulatory functional communications in establishing maintaining drug resistance. Methods resistant cells were characterized by CCK-8, IncuCyte Live-Cell analysis,...