A5021932733- Synthesis of Organic Compounds
- Synthesis and biological activity
- Synthesis and Reactions of Organic Compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Synthesis and pharmacology of benzodiazepine derivatives
- Inorganic and Organometallic Chemistry
- HIV/AIDS drug development and treatment
- Chemical Synthesis and Reactions
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Synthesis of heterocyclic compounds
- Synthesis and Reactivity of Heterocycles
- X-ray Diffraction in Crystallography
- Synthetic Organic Chemistry Methods
- Crystallization and Solubility Studies
- Oxidative Organic Chemistry Reactions
- Analytical Chemistry and Chromatography
- Metal complexes synthesis and properties
- Multicomponent Synthesis of Heterocycles
- Synthesis and Biological Activity
- Organic Chemistry Cycloaddition Reactions
- Synthesis and Biological Evaluation
- Click Chemistry and Applications
- Organic and Inorganic Chemical Reactions
Rhodes University
2013-2022
University of Cambridge
1988-1990
University of KwaZulu-Natal
1984-1988
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTToward the semiquantitative estimation of binding constants. Guides for peptide-peptide in aqueous solutionDudley H. Williams, Jonathan P. L. Cox, Andrew J. Doig, Mark Gardner, Ute Gerhard, Perry T. Kaye, Allick R. Lal, Ian A. Nicholls, Colin Salter, and Robert C. MitchellCite this: Am. Chem. Soc. 1991, 113, 18, 7020–7030Publication Date (Print):August 1, 1991Publication History Published online1 May 2002Published inissue 1 August...
Abstract Marked acceleration of the catalytic coupling aldehydes with methyl acrylate is achieved by varying either aldehyde or system. Rapid and efficient formation heterocyclic derivatives significant synthetic potential described.
Reaction of 2-nitrobenzaldehyde with vinyl carbonyl compounds in the presence 1,4-diazabicyclo[2.2.2]octane affords Baylis–Hillman products, catalytic reduction which results direct cyclisation to quinoline derivatives.
Reactions of 2-hydroxybenzaldehydes and 2-hydroxy-1-naphthaldehydes with various activated alkenes under Baylis–Hillman conditions have been shown to proceed regioselective cyclisation afford the corresponding 3-substituted chromene derivatives. In some cases competitive dimerisation alkene component was observed, direct in absence aldehyde has explored.
Reaction of 2-hydroxybenzaldehydes with alkyl vinyl ketones in the presence 1,4-diazabicyclo[2.2.2]octane proceeds regioselective cyclisation to afford corresponding 2H-1-chromenes yields up 87%.
Evidence is presented which supports the intermediacy of dipolar Baylis-Hillman-type adducts in synthesis coumarin and chromene derivatives from reaction 2-hydroxybenzaldehydes with methyl acrylate presence 1,4-diazabicyclo[2.2.2]octane (DABCO).
Thermal cyclisation of 3-acetoxy-3-(2-pyridyl)-2-methylenepropionate esters and related compounds provides convenient access to 2-substituted indolizines. Detailed one- two-dimensional NMR spectroscopic analysis the title has facilitated interpretation their 1H 13C spectra.
Abstract A kinetic study of the activity mushroom polyphenol oxidase in an organic system was carried out to obtain detailed enzyme data relation optimization reaction conditions and substrate specificity. simple method for consistent measurement rates heterogeneous enzyme/organic solvent (consisting immobilized a hydrated solution chloroform) designed. The aqueous content optimized using p ‐cresol as substrate. With this system, crude extract Agaricus bisporus used hydroxylate oxidize range...
Hydroxyethylene dipeptide isosteres containing chromone, coumarin, chromene, and thiochromene moieties have been prepared as novel analogues of the human immunodeficiency virus (HIV)‐1 protease inhibitor, ritonavir.
M. L. Bode and P. T. Kaye, J. Chem. Soc., Perkin Trans. 1, 1990, 2612 DOI: 10.1039/P19900002612
The preparation of selected (Z)-2-bromomethyl-2-alkenoate esters and their subsequent reaction with acetoacetic ester-derived nucleophiles is described. Both the substrate structure solvent system have significant effects on regioselectivity these nucleophilic displacements.
Reaction of substituted 2-hydroxybenzaldehydes with t-butyl acrylate in the presence DABCO has been shown to afford isolable Baylis-Hillman adducts, acid-catalysed cyclisation which affords corresponding 3-(chloromethyl)coumarins directly and high yield.
Baylis-Hillman reactions of 2-nitrobenzaldehydes with various activated alkenes afford adducts that undergo reductive cyclisation to quinoline derivatives. The chemo- and regioselectivity appears be influenced by the choice both substrate reagent system, competing have been observed.
Halogen acid-catalysed deprotection and cyclisation of Baylis-Hillman products obtained using O-benzylated salicylaldehyde precursors has been shown to afford 3-(halomethyl)coumarins (3-halomethyl-2H-1-benzopyran-2-ones) chemoselectively in good yield.
Abstract Stepwise cyclisation sequences have provided access to a series of novel 4-phenyl-3, 4-dihydro-1,5-benzoxathiepine-2-ones and 2-and 3-phenyl-4, 1-benzoxathiepine analogues.
Abstract Treatment of salicylaldehydes with acrylate derivatives in the presence 1,4-diazabicyclo[2.2.2]octane (DABCO) has been shown to afford both coumarin and chromene derivatives, factors influencing product distributions have investigated.
Iodination of 3-hydroxy-2-methylenealkanoate esters with HI-H3PO4 proceeds exclusive rearrangement, whereas in some cases, chlorination hexachloroacetone–triphenylphosphine affords both normal and rearranged products. Substituent solvent effects on the regioselectivity nucleophilic displacement these halogeno derivatives are discussed.