A5054727607- Renal Transplantation Outcomes and Treatments
- Cytomegalovirus and herpesvirus research
- Hepatitis C virus research
- RNA and protein synthesis mechanisms
- Ubiquitin and proteasome pathways
- Immunotherapy and Immune Responses
- Metabolism and Genetic Disorders
- Immune Cell Function and Interaction
- DNA Repair Mechanisms
- RNA modifications and cancer
- Hepatitis B Virus Studies
- Renal Diseases and Glomerulopathies
- Hate Speech and Cyberbullying Detection
- Lymphoma Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Cancer-related gene regulation
- Viral Infections and Immunology Research
- Organ Transplantation Techniques and Outcomes
- Viral-associated cancers and disorders
- Animal Virus Infections Studies
- RNA Interference and Gene Delivery
- Platelet Disorders and Treatments
- DNA and Nucleic Acid Chemistry
- Transplantation: Methods and Outcomes
- Autoimmune Bullous Skin Diseases
Université de Bretagne Occidentale
2022-2024
Brest State A.S. Pushkin University
2023
Centre Hospitalier Régional Universitaire de Brest
2022-2023
Établissement Français du Sang
2022-2023
Inserm
2022-2023
Stanford University
2014-2015
University of California, San Francisco
2014
California Pacific Medical Center
2012-2013
Early transplant dysfunction and failure because of immunological nonimmunological factors still presents a significant clinical problem for recipients. A critical unmet need is the noninvasive detection prediction immune injury such that acute can be reversed by proactive immunosuppression titration. In this study, we used iTRAQ -based proteomic discovery targeted ELISA validation to discover validate candidate urine protein biomarkers from 262 renal allograft recipients with...
BCL-x is a master regulator of apoptosis whose pre-mRNA alternatively spliced into either long (canonical) anti-apoptotic Bcl-xL isoform, or short (alternative) pro-apoptotic Bcl-xS isoform. The balance between these two antagonistic isoforms tightly regulated and overexpression has been linked to resistance chemotherapy in several cancers, whereas associated some forms diabetes cardiac disorders. splicing factor RBM25 controls alternative BCL-x: its favours the production Bcl-xS,...
Abstract The oncogenic Epstein-Barr virus (EBV) evades the immune system but has an Achilles heel: its genome maintenance protein EBNA1. Indeed, EBNA1 is essential for viral also highly antigenic. Hence, EBV seemingly evolved a in which glycine–alanine repeat (GAr) of limits translation own mRNA to minimal level ensure function, thereby, at same time, minimizing recognition. Therefore, defining intervention points interfere with GAr-based inhibition important step trigger response against...
Protein aggregates and abnormal proteins are toxic associated with neurodegenerative diseases. There several mechanisms to help cells get rid of but little is known on how prevent aggregate-prone from being synthesised. The EBNA1 the Epstein-Barr virus (EBV) evades immune system by suppressing its own mRNA translation initiation in order minimize production antigenic peptides for major histocompatibility (MHC) class I pathway. Here we show that emerging peptide disordered glycine-alanine...
IgA plays a key role in nephropathy (IgAN) by forming immune complexes and depositing the glomeruli, leading to an inflammatory response. However, antigenic targets functional characterization of have been incompletely defined this disease.This study was performed sera from patients who were studied as part prospective, observational IgAN. These (n=22) all had biopsy-proven IgAN within 3 years initiation, complete clinical data, annual urinary inulin clearance for GFRs, at least 5 follow-up....
Human papilloma viruses (HPV) are linked to cancers but how virus-carrying tumour cells express HPV- encoded antigens without attracting the immune system is still poorly understood. Here we show low- and high-risk HPV strains equally exploit a cis-acting mechanism limit translation of E6 mRNA, reducing production antigenic peptide substrates for major histocompatibility class I (MHC-I) pathway. Introducing particular combinations preferable codons throughout HPV-16 mRNA promotes in...
Introduction: Inability to effectively monitor graft injuries leads dysfunction. A non-invasive tool such is an unmet need. Method: Through a robust and comprehensive proteomics analysis, rigorous bioinformatics, ELISA on set of 480 urine samples with matched biopsies, we identified validated potential biomarkers for acute rejection (AR), chronic allograft injury (CAI), BK virus nephropathy (BKVN). Result: panel 100 statistically significant proteins as different transplant identified. Four...
Introduction: Our ability to accurately monitor health status of transplanted organ would define success in the field solid transplantation. Currently available graft monitoring methods suffer from lack strong specificity and sensitivity. Non-invasive more specific biomarkers are unmet need. In this study, we hypothesized that there measurable urine proteins can specifically identify transplant injury phenotypes including acute rejection (AR), BK virus infection (BKV), chronic allograft...