A5029405284- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- Protein purification and stability
- Immunotherapy and Immune Responses
- Selenium in Biological Systems
- Glycosylation and Glycoproteins Research
- RNA Interference and Gene Delivery
- Vaccine Coverage and Hesitancy
- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- RNA and protein synthesis mechanisms
- Epigenetics and DNA Methylation
- Escherichia coli research studies
- Dermatology and Skin Diseases
- Bacteriophages and microbial interactions
- Phytase and its Applications
- Cancer-related molecular mechanisms research
- Helicobacter pylori-related gastroenterology studies
- COVID-19 Clinical Research Studies
- Mycotoxins in Agriculture and Food
- Hepatitis Viruses Studies and Epidemiology
- Ocular Infections and Treatments
- PARP inhibition in cancer therapy
- Infection Control and Ventilation
- Veterinary Pharmacology and Anesthesia
Academic Center for Education, Culture and Research
2022-2024
Motamed Cancer Institute
2022-2024
Kerman University of Medical Sciences
2021-2023
Birjand University of Medical Sciences
2019-2022
Shahid Sadoughi University of Medical Sciences and Health Services
2021
Shahid Beheshti University of Medical Sciences
2016-2020
IS practice
2017
Shahed University
2011-2014
Abstract Targeted drug delivery is one of the attractive ways in which cancer treatment can significantly reduce side effects. In last two decades, use antibodies as a tool for accurate detection has been noted. On other hand, binding drugs and carriers containing to specific cells specifically target only these cells. However, whole brings challenges, including their large size, complexity conjugation, high cost production, creation immunogenic reactions body. The nanobodies, or VHHs, are...
Helicobacter pylori infection is associated with gastritis and in some cases gastric duodenal ulcers, even adenocarcinoma. Antibiotic therapy has significant limitations, such as the high cost emergence of antibiotic-resistant strains, generating need for new treatments. The administration antibody against H. a effective therapeutic strategy. In this study, we successfully developed single-variable domain heavy chain recombinant UreC.A VHH phagemid library was constructed from immune camel...
Prostate cancer is the most common type of in men. The antibody-mediated therapy for treatment depends on identification selected molecular targets. prostate-specific membrane antigen (PSMA) a potential target prostate and abundantly expressed this cancer. This study aimed at designing producing recombinant PSMA epitope monoclonal nanobody with high affinity toward protein. A DNA fragment encoding dominant epitopes was designed, synthesized, E. coli BL21 (DE3). camel immunized purified...
To investigate the incidence of coronavirus disease 2019 (COVID-19) cases, hospitalizations and deaths in Iranians vaccinated with either AZD1222 Vaxzevria, CovIran® vaccine, SARS-CoV-2 Vaccine (Vero Cell), Inactivated (lnCoV) or Sputnik V.We enrolled individuals 18 years older receiving their first COVID-19 vaccine dose between April 2021 January 2022 seven Iranian cities. Participants completed weekly follow-up surveys for 17 weeks (25 AZD1222) to report status hospitalization. We used Cox...
Introduction: Breast cancer is one of the most prevalent malignancies in women. Several treatment options are available today, including surgery, chemotherapy, and radiotherapy. Immunotherapy, as a highly specific therapy, involves adaptive immune responses immunological memory. In our present research, we used recombinant C-terminal domain GRP78 (glucose- regulated protein 78) to induce an response investigate its therapeutic impact 4T1 breast model. Methods: BALB/c mice were immunized with...
Organic selenium compound such as selenomethionine plays a significant function in response to oxidative stress. Currently Saccharomyces cerevisiae is one of the best organisms that has ability accumulate and biotransformation. Addition mineral medium culture very common practice order produce Seleno-proteins. Due toxicity for yeasts, tolerant yeast isolation procedures are required. The aim this investigation was separate indigenous S.cerevisiae strains which will not be affected by high...
Abstract Background Vaccine efficiency has a significant role in the public perception of vaccination. The current study was designed to evaluate efficacy COVID-19 vaccines (AZD-1222, Sputnik-V, Sinopharm, and Covaxin) effect gender on vaccine efficacy. We evaluated these among 214 health care employees Iran. Blood samples were taken from all participants day 0 14 days after second dose. Humoral responses by PT-SARS-CoV-2-Neutralizing-Ab-96. Results frequency immunized individuals Sputnik V...
Bleeding is the most serious complication of warfarin anticoagulation therapy and known to occur even at patients with therapeutic international normalized ratio (INR) range. Recently, it has been shown that microRNAs play a significant role in pharmacogenetics by regulating genes are critical for drug function. Interaction between these target could be affected single-nucleotide polymorphisms (SNPs) located microRNA-binding sites. This study focused on 3'-untranslated region (3'-UTR) SNPs...