A5013788048- Developmental Biology and Gene Regulation
- Zebrafish Biomedical Research Applications
- Nonlinear Photonic Systems
- Quantum Mechanics and Non-Hermitian Physics
- Topological Materials and Phenomena
- Congenital heart defects research
- MXene and MAX Phase Materials
- Epigenetics and DNA Methylation
- Acoustic Wave Resonator Technologies
- Genomics and Chromatin Dynamics
- Ion Transport and Channel Regulation
- Connexins and lens biology
- Advanced ceramic materials synthesis
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer-related Molecular Pathways
- Ferroelectric and Piezoelectric Materials
- Microwave Dielectric Ceramics Synthesis
- Microwave Engineering and Waveguides
- Physiological and biochemical adaptations
- Hedgehog Signaling Pathway Studies
- Terahertz technology and applications
- Advanced materials and composites
- Metamaterials and Metasurfaces Applications
University of Birmingham
2019-2022
Nanchang University
2021-2022
University of California, Irvine
2003-2013
Bone morphogenetic proteins (BMPs) play crucial roles in craniofacial development but little is known about their interactions with other signals, such as Endothelin 1 (Edn1) and Jagged/Notch, which pattern the dorsal-ventral (DV) axis of pharyngeal arches. Here, we use transgenic zebrafish to monitor perturb BMP signaling during arch formation. With a BMP-responsive transgene, Tg(Bre:GFP), show active neural crest (NC)-derived skeletal precursors ventral arches, surrounding epithelia....
AP2 transcription factors regulate many aspects of embryonic development. Studies AP2a (Tfap2a) function in mice and zebrafish have demonstrated a role patterning mesenchymal cells neural crest origin that form the craniofacial skeleton, while mammalian Tfap2b is required both facial skeleton kidney. Here, we show essential functions for tfap2a tfap2b development ectoderm, signals from this epithelium induce skeletogenesis (NCCs). Zebrafish embryos deficient defects epidermal cell survival...
Members of the AP-2 transcription factor family have critical roles in many aspects embryonic development. The zebrafish tfap2a mutant lockjaw (low) displays defects skeletal and pigment cell derivatives neural crest. Here we show essential for subsets cartilages cells. Defects cartilage hyoid arch low correlate with a loss Hox group 2 gene expression are suggestive transformation to mandibular fate. In contrast, joints certain types cells suggest requirement independent regulation. Early...
The zebrafish lens is well suited for studies of physiology and development due to its rapid formation in the embryo genetic accessibility. Aquaporin 0 (AQP0), a lens-specific membrane protein, required clarity. Zebrafish have two copies AQP0 (Aqp0a b), whereas mammals single, multifunctional protein. Here we demonstrate reliable knockdown/rescue system use it provide evidence subfunctionalization Aqp0a b, as show that calcium-mediated regulation lenses necessary transparency.Coinjection...
Inca (induced in neural crest by AP2) is a novel protein discovered microarray screen for genes that are upregulated Xenopus embryos the transcriptional activator Tfap2a. It has no significant similarity to any known protein, but conserved among vertebrates. In Xenopus, zebrafish and mouse embryos, expressed predominantly premigratory migrating (NC). Knockdown experiments frog fish using antisense morpholinos reveal essential functions subset of NC cells form craniofacial cartilage. Cells...
We experimentally demonstrate that high-resolution terahertz focusing can be realized in planar metalenses, which consist of arrays different V-shaped antenna units on a silicon substrate. Numerical results show larger numerical aperture metalenses provide smaller full width at half maximum field distribution, leading to higher spatial resolution. The measurement fabricated samples was performed by near-field imaging system, and experimental agree well with the prediction. Especially for 1.1...
Non-Hermiticity alters topology with the presence of non-Hermitian factors in topological systems. Most existing systems derive their phases from Hermitian components, that is, gain and loss system are considered simultaneously. In this work, we reveal two-dimensional high-order insulator based on one-dimensional SSH chain, nontrivial which induced by total-loss. By introducing a specific configuration, get band gap corner edge states whose is characterized gapped wannier band. addition,...