This prospective, comparative and randomised clinical study evaluated the effectiveness of triple therapy regimen (hydrocortisone, thiamine vitamin C) versus hydrocortisone alone in reducing mortality rate preventing progressive organ dysfunction septic shock patients.A total 94 patients were randomly assigned to one two groups: first group received 50 mg/6-h IV for 7 days or till intensive care unit (ICU) discharge, if sooner, followed by tapering. The second ICU discharge tapering, C 1.5...

Clinical pharmacists play an important role in ensuring the safe and rational use of medicines; however, physicians developing countries may not always recognize wide scope services that a pharmacist can provide to improve patient safety achieve clinical outcomes. The aim this study was investigate perceptions experience regarding pharmacists, pharmacists' ability perform services, their acceptance new roles extent collaboration occur between two disciplines.In cross-sectional survey, 583...

In type 2 diabetes mellitus (T2DM), hyperglycemia leads to oxidative insult. Vitamins A and E have antioxidant potentials may help in managing diabetes. The combined effect of high-dose vitamin plus supplementation with without zinc on T2DM, has never been examined. This study aimed evaluate compare the (AE) versus (AEZ), different diabetic parameters. Ninety-eight patients T2DM were randomized receive either: 50,000 IU 100 mg (AE group, N=36), an equivalent dose 25 (AEZ N=35), or no...

The aim of this work is to report the long-term results using immunotherapy for management cornea and conjunctiva intraepithelial neoplasia squamous cell carcinoma after surgical excision neoplasm.Ten eyes 10 patients with or had wide excisions neoplasm evaluation level corneal involvement ultrasound biomicroscopy. All received topical cyclosporine A (0.05%) mitomycin C (0.01%) 4 times daily 12 weeks surgery. were followed up every month 6 months then another 18 months.All showed total cure...

Abstract Background Left ventricular hypertrophy is a common finding in patients with ischemic heart disease and associated mortality cardiovascular (CVD). Metformin, an antidiabetic drug, has been shown to reduce oxidative stress left mass index (LVMI) animal models. We summarized evidence regarding the effect of metformin on LVMI LVEF. Methods Electronic databases were searched for randomized clinical trials (RCTs) that used non-diabetic or without pre-existing CVD. The standardized mean...

This work aimed to study and evaluate the effect of subconjunctival bevacizumab injection in patients with corneal neovascularization (CNV) resulting from different ocular surface disorders.Ten eyes CNV caused by disorders were studied. All had both major minor vessel factors such as healed ulcers, long-standing chronic inflammatory diseases ischaemia (caused contact lenses). received a single 2.5mg (0.1ml) bevacizumab. Morphological changes vessels evaluated using slit-lamp biomicroscopy...

No value sets exist for either the EQ-5D-3L or EQ-5D-5L in Egypt, despite local pharmacoeconomic guidelines recommending use of EQ-5D to derive utility. Most published Egyptian economic evaluation studies have used utility values from other and systematic reviews.Our objective was develop an set using international EuroQol standardized protocol (EQ-VT-2.1). This study is a revision previous Egypt retracted by authors.Adult participants were recruited public places multi-stratified quota...

No value sets exist for either the EQ-5D-3L or EQ-5D-5L in Egypt, despite local pharmacoeconomic guidelines recommending use of EQ-5D to derive utility. Most published Egyptian economic evaluation studies have used utility values from other and systematic reviews. Our objective was develop an set using international EuroQol standardized protocol (EQ-VT-2.1). Adult participants were recruited public places multi-stratified quota sampling based on age, sex, geographical distribution. Two...

Abstract Rationale, aims and objectives Hospital pharmacists can promote medication safety through spontaneous reporting of adverse drug reactions ( ADRs ). However, different educational interventions factors (socio‐demographic professional) have been implicated to influence the process. The this study were assess impact pharmacovigilance awareness workshop on knowledge hospital pharmacists; identify main barriers that reporting. Methods Two validated self‐administered questionnaires...

Ursodeoxycholic acid (UDCA) possesses a hepatoprotective effect in drug-induced hepatotoxicity. In prospective randomized parallel study, 39 children with acute lymphoblastic leukemia (ALL) were to receive UDCA chemotherapy for 6 months, then discontinued and followed up 3 (UDCA group) (N = 19) or without 9 months (control 20). this pilot treatment was associated trend toward decreased levels of hepatic transaminases when concomitantly administered and, therefore, safer outcome ALL. Future...

Drug shortage is a problem that entangles health systems. In Egypt, many complaints arose due to drug in the period following 25th January revolution. Physicians play vital role dealing with this crisis. Our aim was investigate physicians' perspective of and its impact on healthcare system. A questionnaire adopted distributed by hand physicians customers' waiting areas Medical Syndicates Union. The covered general participant information, effects, responses problem, magnitude development...

Iron overload-induced oxidative stress and transfusion-acquired hepatitis C virus (HCV) infection are the main reasons of liver damage in beta thalassemia major (β-TM).Based on metformin's hepatic benefits nondiabetic populations, study aims to investigate safety potential hepatoprotective effect metformin HCV-infected β-TM adolescent patients.This was a prospective, randomised, parallel, controlled, open-label which 60 patients aged 11 18 years receiving no antiviral therapy were selected...

Introduction: There is an increasing interest in using metformin cardiovascular diseases and its potential new roles. Only two randomized controlled trials investigated the effect of nondiabetic heart failure (HF) patients. However, none these studies assess role reducing oxidative stress. We hypothesized that might improve stress left ventricular remodeling HF patients with reduced ejection fraction (HFrEF).