A5032065488- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Advanced biosensing and bioanalysis techniques
- Viral Infections and Vectors
- COVID-19 and healthcare impacts
- Fire effects on ecosystems
- Biosensors and Analytical Detection
- Climate variability and models
Nanjing Drum Tower Hospital
2023-2025
Nanjing Medical University
2023-2025
Second Affiliated Hospital of Zhejiang University
2020
ABSTRACT Simnotrelvir is an oral small-molecule antiviral agent targeting the 3C-like protease (3CL pro ) of SARS-CoV-2, proven effective against Delta variant with favorable pharmacokinetics and safety in preclinical study. In this study, we further evaluated efficacy simnotrelvir a range emerging Omicron variants, including BA.1, BA.4, BA.5, CH.1.1, XBB.1.5, XBB.1.16, EG.5, JN.1. vitro assays Vero E6 cells confirmed that exhibited robust activity across these comparable to Food Drug...
The unprecedented public health and economic impact of the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) infection has been met with an equally scientific response. Sensitive point-of-care methods to detect SARS-CoV-2 antigens in clinical specimens are urgently required for rapid screening individuals viral infection. Here, we developed upconversion nanoparticle-based lateral flow immunochromatographic assay (UCNP-LFIA)...
Severe fever with thrombocytopenia syndrome (SFTS) is a rapidly progressing infectious disease caused by novel bunyavirus characterized high fever, thrombocytopenia, and multiple organ damage. While lipids play an important role in viral infections, the specific alterations lipid metabolism during SFTSV infection remain unclear. This study aimed to elucidate global metabolic profiles of SFTS patients mild, severe, fatal outcomes. A total 60 patients, consisting 30 15 severe healthy controls,...