A5008804569- Pulmonary Hypertension Research and Treatments
- RNA modifications and cancer
- Coenzyme Q10 studies and effects
- DNA Repair Mechanisms
- Tissue Engineering and Regenerative Medicine
- Galectins and Cancer Biology
- Protein Tyrosine Phosphatases
- Telomeres, Telomerase, and Senescence
- Fungal and yeast genetics research
- Pluripotent Stem Cells Research
- Peptidase Inhibition and Analysis
- Electrospun Nanofibers in Biomedical Applications
- Cardiovascular Function and Risk Factors
- Plant Reproductive Biology
- Cardiac Fibrosis and Remodeling
- Mesenchymal stem cell research
- Yeasts and Rust Fungi Studies
Institute of Biological Chemistry, Academia Sinica
2022-2024
Academia Sinica
2024
Abstract T-Cell Protein Tyrosine Phosphatase (TCPTP, PTPN2) is a non-receptor type protein tyrosine phosphatase that ubiquitously expressed in human cells. TCPTP critical component of variety key signaling pathways are directly associated with the formation cancer and inflammation. Thus, understanding molecular mechanism activation regulation essential for development therapeutics. Under basal conditions, largely inactive, although how this achieved poorly understood. By combining...
Pulmonary hypertension (PH) is a major complication linked to adverse outcomes in heart failure with preserved ejection fraction (HFpEF), yet no specific therapies exist for PH associated HFpEF (PH-HFpEF). We have recently reported on the role of skeletal muscle SIRT3 (sirtuin-3) modulation PH-HFpEF, suggesting novel endocrine signaling pathway pulmonary vascular remodeling.
Abstract Alternative Lengthening of Telomeres (ALT) utilizes a recombination mechanism and break-induced DNA synthesis to maintain telomere length without telomerase, but it is unclear how cells initiate ALT. TERRA, telomeric repeat-containing RNA, forms RNA:DNA hybrids (R-loops) at ALT telomeres. We show that depleting TERRA using an RNA-targeting Cas9 system reduces ALT-associated PML bodies, clustering, lengthening. interactome reveals interacts with extensive subset repair proteins in...
Tissue (re)vascularization strategies face various challenges, as therapeutic cells do not survive long enough in situ, while the administration of pro-angiogenic factors is hampered by fast clearance and insufficient ability to emulate complex spatiotemporal signaling. Here, we propose address these limitations engineering a functional biomaterial capable capturing concentrating activities mesenchymal stem (MSCs). In particular, dextran sulfate, high molecular weight sulfated glucose...
Abstract Dobzhansky–Muller incompatibilities represent a major driver of reproductive isolation between species. They are caused when interacting components encoded by alleles from different species cannot function properly mixed. At incipient stages speciation, complex involving multiple genetic loci with weak effects frequently observed, but the underlying mechanisms remain elusive. Here we show perturbed proteostasis leading to compromised mitosis and meiosis in Saccharomyces cerevisiae...
BACKGROUND: Pulmonary hypertension (PH) represents an important phenotype in heart failure with preserved ejection fraction (HFpEF). However, management of PH-HFpEF is challenging because mechanisms involved the regulation remain unclear. METHODS: We used a mass spectrometry–based comparative plasma proteomics approach as sensitive and comprehensive hypothesis-generating discovery technique to profile proteins patients control subjects. then validated investigated role one identified using...