A5011172726- Traumatic Brain Injury and Neurovascular Disturbances
- Optical Imaging and Spectroscopy Techniques
- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- S100 Proteins and Annexins
- Non-Invasive Vital Sign Monitoring
- Acute Ischemic Stroke Management
- Hemodynamic Monitoring and Therapy
- Anesthesia and Neurotoxicity Research
- Cerebrospinal fluid and hydrocephalus
- Anesthesia and Sedative Agents
- Neurosurgical Procedures and Complications
- Sepsis Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- Radiation Dose and Imaging
- Neonatal and fetal brain pathology
- Trauma and Emergency Care Studies
- Machine Learning in Healthcare
- Infrared Thermography in Medicine
- Climate Change and Health Impacts
- Advanced X-ray and CT Imaging
- Healthcare Technology and Patient Monitoring
- EEG and Brain-Computer Interfaces
- Thermal Regulation in Medicine
- Intensive Care Unit Cognitive Disorders
Karolinska Institutet
2024-2025
University of Manitoba
2020-2024
University of Winnipeg
2023-2024
Karolinska University Hospital
2024
The contemporary monitoring of cerebrovascular reactivity (CVR) relies on invasive intracranial pressure (ICP) which limits its application. Interest is shifting towards near-infrared spectroscopic regional cerebral oxygen saturation (rSO2)-based indices CVR are less and have improved spatial resolution. This study aims to examine model the relationship between ICP rSO2-based CVR. Through a retrospective cohort prospectively collected physiologic data in moderate severe traumatic brain...
Abstract Background Near-infrared spectroscopy regional cerebral oxygen saturation (rSO 2 ) has gained interest as a raw parameter and basis for measuring cerebrovascular reactivity (CVR) due to its noninvasive nature high spatial resolution. However, the prognostic utility of these parameters not yet been determined. This study aimed identify threshold values rSO -based CVR at which outcomes worsened following traumatic brain injury (TBI). Methods A retrospective multi-institutional cohort...
Goal: Current methodologies for assessing cerebral compliance using pressure sensor technologies are prone to errors and issues with inter- intra-observer consistency. RAP, a metric measuring intracranial compensatory reserve (and therefore compliance), holds promise. It is derived the moving correlation between (ICP) pulse amplitude of ICP (AMP). RAP remains largely unexplored in cases moderate severe acute traumatic neural injury (also known as brain (TBI)). The goal this work explore...
Acute traumatic neural injury, also known as brain injury (TBI), is a leading cause of death. TBI treatment focuses on the use sedatives, vasopressors, and invasive intracranial pressure (ICP) monitoring to mitigate ICP elevations maintain cerebral perfusion (CPP). While common sedatives such propofol fentanyl have significant side effects, ketamine an attractive alternative due its rapid onset cardiovascular stability. Despite these benefits, ketamine's remains controversial historical...
Continuous metrics of cerebral autoregulation (CA) assessment have been developed using various multimodal physiological monitoring devices. However, CA regional disparity remains unclear in states health and disease. Leveraging existing archived data sources, we preliminarily evaluated hemispheric the near infrared spectroscopy (NIRS)-derived oximetry index (COx/COx-a). Along with bilateral NIRS, oxygen saturation, arterial blood pressure, perfusion COx/COx-a were derived three different...
INTRODUCTION: Global clinical outcomes are known to be associated with dysfunctional cerebrovascular reactivity (CVR) following traumatic brain injury (TBI). However, the association of CVR in acute and chronic phase patient-reported health-related quality life (HRQOL) metrics has never been explored. METHODS: In this prospective cohort study, between continuous patient reported HRQOL moderate severe TBI was examined for first time. The main interest study were validated measures over...
Abstract Intravenous norepinephrine (NE) is utilized commonly in critical care for cardiovascular support. NE’s impact on cerebrovasculature unclear and may carry important implications during states of neurological illness. The aim the study was to perform a scoping review literature cerebrovascular/cerebral blood flow (CBF) effects NE. A search MEDLINE, BIOSIS, EMBASE, Global Health, SCOPUS, Cochrane Library from inception December 2019 performed. All manuscripts pertaining administration...
The impact of vasopressor and sedative drugs on cerebrovascular reactivity in traumatic brain injury (TBI) remains unclear. aim this study was to evaluate the changes doses commonly administered sedation (i.e., propofol, fentanyl, ketamine) agents norepinephrine [NE], phenylephrine [PE], vasopressin[VSP]) compensatory reserve patients with moderate/severe TBI. Using Winnipeg Acute TBI Database, we identified 38 more than 1000 distinct infusion rates 500 h paired drug infusion/physiology...
Intravenous propofol, fentanyl, and midazolam are utilized commonly in critical care for metabolic suppression anesthesia. The impact of on cerebrovasculature cerebral blood flow (CBF) is unclear traumatic brain injury (TBI) may carry important implications, as shifting to focus cerebrovascular reactivity monitoring/directed therapies. aim this study was perform a scoping review the literature cerebrovascular/CBF effects human patients with moderate/severe TBI animal models TBI. A search...
Near-infrared spectroscopy (NIRS) regional cerebral oxygen saturation (rSO2)-based cerebrovascular reactivity (CVR) monitoring has enabled entirely non-invasive, continuous during both acute and long-term phases of care. To date, post-injury CVR not been properly characterized after traumatic neural injury, also known as brain injury (TBI). This study aims to compare in those recovering from moderate-to-severe TBI with a healthy control group. A total 101 heathy subjects were recruited for...
Goal: Cerebrovascular reactivity (CVR) dysfunction is a contributor to secondary injury in traumatic brain (TBI). The issue with applying non-overlapping moving average filters reduce temporal resolution of high CVR data that the autocorrelative structure ignored. It violates priors linearity and raises concerns for level certainty any reported models. goal assess if there cerebral physiology where Box-Jenkin's time-series statistical structures can be indices were derived varying...
Cerebrovascular reactivity has been identified as a key contributor to secondary injury following traumatic brain (TBI). Prevalent intracranial pressure (ICP) based indices of cerebrovascular are limited by their invasive nature and poor spatial resolution. Fortunately, interest building around near infrared spectroscopy (NIRS) measures that utilize regional cerebral oxygen saturation (rSO2) surrogate for pulsatile blood volume (CBV). In this study, the relationship between ICP- rSO2-based...
Abstract Background Brain tissue oxygen tension (PbtO 2 ) and cerebrovascular pressure reactivity monitoring have emerged as potential modalities to individualize care in moderate severe traumatic brain injury (TBI). The relationship between these has had limited exploration. aim of this study was examine the PbtO cerebral perfusion (CPP) how is modified by state reactivity. Methods A retrospective multi-institution cohort utilizing prospectively collected high-resolution physiologic data...
The modeling and forecasting of cerebral pressure–flow dynamics in the time–frequency domain have promising implications for veterinary human life sciences research, enhancing clinical care by predicting blood flow (CBF)/perfusion, nutrient delivery, intracranial pressure (ICP)/compliance behavior advance. Despite its potential, literature lacks coherence regarding optimal model type, structure, data streams, performance. This systematic scoping review comprehensively examines current...