A5017817427- Innovations in Medical Education
- Atherosclerosis and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Clinical Reasoning and Diagnostic Skills
- Reflective Practices in Education
- Cell Adhesion Molecules Research
- Coronary Interventions and Diagnostics
- Protease and Inhibitor Mechanisms
- Cardiac Imaging and Diagnostics
- Radiology practices and education
- Cardiovascular Disease and Adiposity
- Blood Coagulation and Thrombosis Mechanisms
- Angiogenesis and VEGF in Cancer
- Cardiovascular Health and Disease Prevention
- Student Assessment and Feedback
- Evaluation of Teaching Practices
- Medical Education and Admissions
- Acute Ischemic Stroke Management
- Chemotherapy-induced cardiotoxicity and mitigation
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Higher Education Learning Practices
- Healthcare professionals’ stress and burnout
- Signaling Pathways in Disease
- Muscle metabolism and nutrition
Maastricht University
2016-2025
WaterNSW
2024
Radboud University Nijmegen
2022
Radboud University Medical Center
2022
University Medical Center Groningen
2022
Maastricht University Medical Centre
2006-2021
University of Amsterdam
2003-2021
Amsterdam UMC Location University of Amsterdam
2010-2021
Uniformed Services University of the Health Sciences
2020
's Heeren Loo
2020
Programmatic assessment is an integral approach to the design of program with intent optimise its learning function, decision-making function and curriculum quality-assurance function. Individual methods assessment, purposefully chosen for their alignment outcomes information value learner, teacher organisation, are seen as individual data points. The these points maximised by giving feedback learner. There a decoupling moment decision moment. Intermediate high-stakes decisions based on...
It is widely acknowledged that assessment can affect student learning. In recent years, attention has been called to 'programmatic assessment', which intended optimise both learning functions and decision at the programme level of assessment, rather than according individual methods assessment. Although concept attractive, little research into its effects on students their conducted.This study investigated elements programmatic perceived as supporting or inhibiting learning, factors...
Vascular lipid accumulation and inflammation are hallmarks of atherosclerosis perpetuate atherosclerotic plaque development. Mediators inflammation, ie, interleukin (IL)-6, elevated in patients with acute coronary syndromes may contribute to the exacerbation atherosclerosis.To assess role IL-6 atherosclerosis, ApoE-/--IL-6-/- double-knockout mice were generated, fed a normal chow diet, housed for 53+/-4 weeks. Mortality blood pressure unaltered. However, serum cholesterol levels subsequent...
In the present study, we investigated role of CD40L-CD40 pathway in a model progressive atherosclerosis. ApoE−/− mice were treated with an anti-CD40L antibody or control for 12 wk. Antibody treatment started early (age 5 wk) was delayed until after establishment atherosclerosis 17 wk). both and groups, did not decrease plaque area inhibit lesion initiation age-related increase area. The morphology initial lesions affected, except T-lymphocyte content. Effects on advanced pronounced. content...
Background— Cathepsin K (catK), a lysosomal cysteine protease, was identified in gene-profiling experiment that compared human early plaques, advanced stable and atherosclerotic plaques containing thrombus, where it highly upregulated plaques. Methods Results— To assess the function of catK atherosclerosis, −/− /apolipoprotein (apo) E mice were generated. At 26 weeks age, plaque area /apoE reduced (41.8%) owing to decrease number lesions as well individual area. This suggests an important...
Thrombin generation in vivo may be important regulating atherosclerotic progression. In the present study, we examined for first time activity and presence of relevant coagulation proteins relation to progression atherosclerosis.Both early stable advanced lesions were collected pairwise from each individual (n=27) during autopsy. Tissue homogenates prepared both total plaques isolated plaque layers, which factors (F) II, X, XII tissue factor was determined. Microarray analysis implemented...
Osteoclastic bone degradation involves the activity of cathepsin K. We found that in addition to this enzyme other, yet unknown, cysteine proteinases participate digestion. The results support notion osteoclasts from different sites use enzymes degrade collagenous matrix.The osteoclast resorbs by lowering pH resorption lacuna, which is followed secretion proteolytic enzymes. One taken be essential proteinase, Some immunolabeling and inhibitor data, however, suggest other and/or belonging...
Rupture-prone atherosclerotic plaques are characterized by inflammation and a large necrotic core. Inflammation is linked to high metabolic activity. Advanced glycation endproducts (AGEs) their major precursor methylglyoxal formed during activity can have detrimental effects on cellular function may induce cell death. Therefore, we investigated whether plaque AGEs increased in human carotid rupture-prone associated with core formation. The protein-bound methylglyoxal-derived AGE...
One major intracellular signaling pathway involved in heart failure employs the phosphatase calcineurin and its downstream transcriptional effector nuclear factor of activated T-cells (NFAT). In vivo evidence for involvement NFAT factors development is still ill defined. Here we reveal that nfatc2 transcripts outnumber those from other nfat genes unstimulated by severalfold. Transgenic mice with postnatal myocardium crossbred nfatc2-null revealed a significant abrogation calcineurin-provoked...
Background Variations in the blood coagulation activity, determined genetically or by medication, may alter atherosclerotic plaque progression, influencing pleiotropic effects of proteases. Published experimental studies have yielded contradictory findings on role hypercoagulability atherogenesis. We therefore sought to address this matter extensively investigating vivo significance genetic alterations and pharmacologic inhibition thrombin formation for onset progression atherosclerosis,...
Objectives Within programmatic assessment, the ambition is to simultaneously optimise feedback and decision-making function of assessment. In this approach, individual assessments are intended be low stakes. practice, however, learners often perceive designed stakes as high study, we explored how assessment within which factors influence these perceptions. Methods Twenty-six were interviewed from three different countries five programmes, ranging undergraduate postgraduate medical education....
In the Ottawa 2018 Consensus framework for good assessment, a set of criteria was presented systems assessment. Currently, programmatic assessment is being established in an increasing number programmes. this 2020 consensus statement insights from practice and research are used to define principles assessment.For fifteen programmes health professions education affiliated with members expert group (n = 20), inventory completed perceived components, rationale, importance design. Input...
Smokers are at increased risk of cardiovascular events. However, the exact mechanisms through which smoking influences disease resulting in accelerated atherosclerosis and vascular calcification unknown. The aim this study was to investigate effects nicotine on initiation smooth muscle cell (VSMC) elucidate underlying mechanisms.We assessed 62 carotid lesions both non-smoking patients using ex vivo micro-computed tomography (µCT) scanning. Calcification present more often plaques smokers (n...
Several signal transduction events induced by angiotensin II (AngII) binding to the type 1 receptor resemble those evoked platelet-derived growth factor (PDGF) PDGF-beta (PDGFbeta-R). We report here, in agreement with previous data, that AngII and PDGF-B-chain homodimer (PDGF-BB) stimulate tyrosine phosphorylation of PDGFbeta-R. Both PDGF-BB stimulated PDGFbeta-R via tyrosine-phosphorylated Shc PDGF-BB- AngII-induced Shc.PDGFbeta-R complex was inhibited antioxidants such as N-acetylcysteine...
To prospectively determine, by using a stepwise logistic regression model, the optimal magnetic resonance (MR) weighting (ie, pulse sequence) combinations for plaque assessment and corresponding cutoff values of relative signal intensities (rSIs).Institutional review board approval patient consent were obtained. Eleven patients (seven men, four women; mean age +/- standard deviation, 68 years 4) with symptomatic carotid disease stenosis more than 70% investigated at MR imaging before...