A5103892119- Polyomavirus and related diseases
- Viral-associated cancers and disorders
- Parvovirus B19 Infection Studies
- Cytomegalovirus and herpesvirus research
- Renal Diseases and Glomerulopathies
- Chronic Lymphocytic Leukemia Research
- Parasites and Host Interactions
- Cardiomyopathy and Myosin Studies
- Amino Acid Enzymes and Metabolism
- Renal Transplantation Outcomes and Treatments
- Oral and gingival health research
- Diabetes Treatment and Management
- Studies on Chitinases and Chitosanases
- Mycobacterium research and diagnosis
- Lymphoma Diagnosis and Treatment
- Amoebic Infections and Treatments
- Breast Lesions and Carcinomas
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Breast Cancer Treatment Studies
- Complement system in diseases
- Cancer and Skin Lesions
- Cell Adhesion Molecules Research
- Global Health Workforce Issues
- Lysosomal Storage Disorders Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Westmead Hospital
2014-2024
The University of Sydney
2024
South Australia Pathology
2020
Reactivation of BK virus in renal allografts causes a destructive chronic infection. This single-center retrospective cohort study describes the evolution allograft nephropathy (BKVAN) from 63 kidneys (from 61 patients) using sequential histopathology (454 biopsies, averaging 7.8 ± 2.6 per kidney) followed for 60.1 mo. Uninfected protocol biopsies formulated time-matched control Banff scores (n = 975). Interstitial inflammation occurred 73% at diagnosis, correlating with viral (r 0.413, p...
Reactivation of BK polyoma virus can result in destructive viral allograft nephropathy (BKVAN) with limited treatment options. Screening programs using surrogate markers replication are important preventive strategies, guiding immunosuppression reduction.We prospectively evaluated the diagnostic test performance urinary decoy cells and SV40T immunochemistry exfoliated cells, to screen for BKVAN, (defined by reference histology SV40 immunohistochemistry, n = 704 samples), compared...
Sentinel lymph node biopsy in breast cancer is a routine technique for staging the axilla. The two most common methods of intraoperative histopathological assessment, imprint cytology and frozen section, are hampered by poor sensitivity lack standardized methodology. one-step nuclei acid amplification (OSNA) assay rapid quantification cytokeratin 19 mRNA. This prospective study compared an existing protocol with OSNA system.Of 110 prospectively recruited patients, 98 met inclusion criteria...
Background and objectives The published tissue adequacy requirement of kidney medulla for BK virus allograft nephropathy diagnosis lacks systematic verification competes against potential increased procedural risks from deeper sampling. Design, setting, participants, & measurements We evaluated whether the presence improved diagnostic rate in 2244 consecutive biopsy samples 856 transplants with detailed histologic virologic results. Results Medulla was present 821 (37%) correlated...
Background. Interstitial inflammation (i-INT) is the driver of T-cell–mediated rejection. Its causes, pathophysiology, kinetics, and outcomes are poorly documented. Methods. The role i-INT was evaluated in 2055 biopsies from 775 renal transplant recipients. Results. present 374 (18.2% prevalence) acute subclinical rejection (67.4%); interstitial fibrosis tubular atrophy (14.4%); BK virus nephropathy (BKVAN) 9.9%; necrosis (ATN with i-INT) 5.9% cases. predicted by prior BKVAN, human leukocyte...
The newer antidiabetic medications have revolutionized management of diabetes.These include the sodium-glucose cotransporter 2 (SGLT2) inhibitors and long-acting glucagon-like peptide 1 (GLP-1) receptor agonists.These two classes drugs provide additional cardiovascular renal benefits beyond glycemic control, making them attractive choices in this new era diabetes therapy.The these weight loss improved blood pressure control.They a limited number adverse effects, including urinary tract...
A 70‐year‐old immunocompetent Lebanese male presented with 3‐month history of watery diarrhoea and abdominal pain after recently arriving to Australia from Lebanon. He had a colectomy for an iatrogenic bowel perforation associated colonoscopy in Lebanon several months prior. His computed tomography (CT) scan demonstrated pancolitis. Stool culture polymerase chain reaction (PCR) were positive Strongyloides stercoralis . Despite treatment total parenteral nutrition, his pancolitis unexpectedly...