A5055073084- Xenotransplantation and immune response
- Animal Genetics and Reproduction
- Neuropeptides and Animal Physiology
- Cell Adhesion Molecules Research
- RNA and protein synthesis mechanisms
- Immunotherapy and Immune Responses
- Complement system in diseases
- Receptor Mechanisms and Signaling
- Biochemical and Structural Characterization
- Glycosylation and Glycoproteins Research
- Antifungal resistance and susceptibility
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- Mass Spectrometry Techniques and Applications
- Immune Response and Inflammation
- Tissue Engineering and Regenerative Medicine
- Streptococcal Infections and Treatments
- Fungal Infections and Studies
- Virus-based gene therapy research
- Immune Cell Function and Interaction
University of North Carolina at Chapel Hill
2024
Novartis (United Kingdom)
2003
Novartis (France)
2001-2002
University of Cambridge
2001
Abstract Integrins αvβ6 and αvβ8 in the tumor microenvironment (TME) have been shown to activate immunosuppressive TGF-β, which serves as an important mechanism for immune checkpoint inhibitor resistance a range of tumors. In this study, we demonstrate utility lasso peptides versatile scaffolds designing new therapeutics. A series highly potent selective dual αvβ6/8 inhibitors were engineered through combination epitope scanning, computational design, directed evolution. Several analogs,...
Abstract Lasso peptides exhibit a unique lariat-like knotted structure imparting exceptional stability and thus show promise as therapeutic agents that target cell-surface receptors. One such receptor is the human endothelin ET B receptor, which implicated in challenging cancers with poor immunotherapy responsiveness. The Streptomyces -derived lasso peptide, RES-701-3, selective inhibitor for compelling candidate development. However, meager production from genetically recalcitrant host has...
Abstract: Allotransplantation of human foetal neural tissue for neurodegenerative disorders has been shown to provide clinical benefit but is limited by a number issues including donor supply. The use porcine as an alternative source cells being investigated xenotransplants survive poorly result immunological rejection, which may involve complement. In this study we the expression membrane‐bound complement regulatory proteins – decay accelerating factor (DAF), membrane co‐factor protein...
Fetal porcine neural xenografts are an alternative to human fetal tissue for cell based treatments of a number neurodegenerative conditions but currently limited by host immunological rejection. The expression major epitope, Galα1-3Galβ1-4GlcNAcβ-R (αGal) was determined on stem cells and primary derived from E26 brains. α Gal detected the majority suspensions. this epitope paralleled binding IgG IgM cells, that significantly reduced with anti-αGal depleted serum. This study demonstrates αGal...
is a fungal pathogen that can cause lethal disease in immunocompromised patients. Immunocompetent host immune responses, such as formation of pulmonary granulomas, control the infection and prevent disseminated disease. Little known about immunological conditions establishing latent granuloma lungs. To investigate this, we performed an analysis cell populations, cytokine changes, during with disease-causing clinical isolate C3HeB/FeJ mice over 360 days. We found latently infected progress...
Conference Abstract| February 01 2001 MHC and α Gal Expression in Porcine Fetal Neural Tissue T. Harrower; Harrower *Cambridge Centre for Brain Repair, Forvie Site, Cambridge, CB22PY Search other works by this author on: This Site PubMed Google Scholar G. Cruz; Cruz ΨImutran Ltd (A Novartis Pharma AG Co), PO Box 399, CB22AH L. Copeman; Copeman A. Richards; Richards S. Dunnett; Dunnett R. Barker Clin Sci (Lond) (2001) 100 (s44): 13P. https://doi.org/10.1042/cs100013P Views Icon Article...