A5102817252- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Fungal and yeast genetics research
- Bioinformatics and Genomic Networks
- Microbial Metabolic Engineering and Bioproduction
- interferon and immune responses
- Cancer Diagnosis and Treatment
- Gene expression and cancer classification
- ATP Synthase and ATPases Research
- Horticultural and Viticultural Research
- Cancer, Hypoxia, and Metabolism
- Fermentation and Sensory Analysis
- Adipose Tissue and Metabolism
- Genomics and Chromatin Dynamics
- Peroxisome Proliferator-Activated Receptors
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
Immuneering (United States)
2017-2021
Harvard University
2015
Significance Almost all biological systems need to respond multiple simultaneous inputs. In yeast catabolite repression, a textbook model for signaling integration, the preferred carbohydrate glucose is thought inhibit induction of galactose genes when above threshold concentration. Instead, we show that metabolic depends on ratio and glucose. Surprisingly, critical portion information processing determines response occurs upstream canonical pathway. The use modern combinatorial approaches...
Abstract Cachexia is a common cause of morbidity across multiple cancer types, yet remains largely under-studied especially in the realm transcriptomics. An essential component cachexia induced transition adipocytes from white to brown, which increases energetic inefficiency and contributes systemic loss adipose tissue. This likely caused by tumor secreting thermo-stimulatory factors into extracellular space. Here, we integrate publicly-available data pinpoint actionable gene targets that...
Abstract Five-year survival rates for patients whose cancer has metastasized are dramatically lower than those with localized disease. However, few therapeutic development efforts specifically focus on inhibiting the process of metastasis. Here we perform a systematic pan-cancer analysis RNA-seq data from The Cancer Genome Atlas to identify targetable gene expression changes in primary tumors that confer metastatic potential. In 4,844 comprising 13 different types, construct signature...
Abstract In nature, microbes often need to “decide” which of several available nutrients utilize, a choice that depends on cell’s inherent preference and external nutrient levels. While natural environments can have mixtures different nutrients, phenotypic variation in microbes’ decisions utilize is poorly studied. Here, we quantified differences the concentration glucose galactose required induce galactose-responsive (GAL) genes across 36 wild S. cerevisiae strains. Using bulk segregant...
Abstract Introduction: Targeting metastasis has the potential to reduce lethality of cancer, instead making it a manageable disease. While been studied extensively in individual forms less attention paid aspects metastatic progression conserved across cancers. Here, we identify mechanisms consistently associated with primary tumors from 4106 patients 12 different cancers via comparison primary-site no lymph node involvement those staging other tissues or nodes. Methods: Leveraging RNA-seq...