Solubilities of amlodipine besylate, a calcium channel blocker drug, in supercritical carbon dioxide (SCCO2) were measured for the first time temperature range (308, 318, 328 and 338) K pressure (12 to 27) MPa with an equilibrium cell. Measured solubilities (in mole fraction) 4.15 × 10–6 11.7 at 308 K, 7.04 13.5 318 9.89 18.5 11 23 338 K. Six empirical models, proposed by Chrastil, Garlapati–Madras (reformulated Chrastil), Mendez-Santiago–Teja, Bartle et al., Sodeifian Tippana–Garlapati...

Knowing the solubility data of pharmaceutical compounds in supercritical carbon dioxide (ScCO2) is essential for nanoparticles formation by using technology. In this work, solid pantoprazole sodium sesquihydrate ScCO2 determined and reported at 308, 318, 328 338 K pressures between 12 27 MPa. The solubilities are ranged 0.0301 [Formula: see text] 10-4 0.463 mole fraction. modelled with a new model solid-liquid equilibrium criteria required activity coefficient developed regular solution...

A static method is employed to determine the solubilities of verapamil in supercritical carbon dioxide (SC-CO2) at temperatures between 308 and 338 K pressures 12 30 MPa. The solubility SC-CO2 expressed as mole fraction are range 3.6 × 10-6 7.14 10-5. Using four semi-empirical density-based models, data correlated: Chrastil, Bartle, Kumar-Johnston (K-J), Mendez-Santiago Teja (MST), two equations state (SRK PC-SAFT EoS), expanded liquid models (modified Wilson's models), regular solution...

A supercritical fluid, such as carbon dioxide (scCO2) is increasingly used for the micronization of pharmaceuticals in recent past. The role scCO2 a green solvent fluid (SCF) process decided by solubility information pharmaceutical compound scCO2. commonly SCF processes are rapid expansion solution (RESS) and antisolvent precipitation (SAS). To implement process, required. Present study aimed at both measuring modeling solubilities hydroxychloroquine sulfate (HCQS) Experiments were conducted...

The solubility of an anti-hyperglycemic agent drug, (R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro [1,2,4] triazolo[4,3-a] pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl) butan-2-amine (also known as Sitagliptin phosphate) in supercritical carbon dioxide (scCO2) was determined by ananalytical and dynamic technique at different temperatures (308, 318, 328 338 K) pressure (12-30 MPa) values. measured solubilities were the range 3.02 × 10-5 to 5.17 10-5, 2.71 5.83 2.39 6.51 2.07 6.98 mole fraction...

In order to design and perform the processes of nano- microparticle production via supercritical carbon dioxide (SC-CO2), solubility data information a solid solute such as pharmaceutical component in SC-CO2 is principally needed. Therefore, drug solubility, 2,4,7-triamino-6-phenylpteridine (TRM), was determined at 308, 318, 328 338 K from 12 27 MPa present study. Solubility mole fraction TRM ranged between 0.42 × 10–5 1.83 10–5, 0.32 2.13 0.09 2.34 0.03 2.89 328, K, respectively. According...

Abstract The solubility of empagliflozin in supercritical carbon dioxide was measured at temperatures (308 to 338 K) and pressures (12 27 MPa), for the first time. terms mole faction ranged from 5.14 × 10 –6 25.9 . cross over region observed 16.5 MPa. A new model derived correlate data using solid–liquid equilibrium criteria combined with Wilson activity coefficient infinite dilution coefficient. proposed correlated average absolute relative deviation (AARD) Akaike’s information criterion...

Abstract Measurement of saturation solubility drugs in a supercritical fluid is an important parameter for the implementation technology pharmaceutical industry. CO 2 most sorted substance as since it has attractive properties like easily achievable critical temperature, moderate pressure. Cancer increasingly affecting mankind, proper dosage while treating would help minimizing drug usage. The bioavailability mainly influenced by particle size. An appropriate always useful making suitable...

Abstract The accurate experimental determination of pharmaceutical compound solubilities at various temperature and pressure ranges in supercritical carbon dioxide (ScCO 2 ) is a challenging time‐consuming task. Therefore, prediction or correlations solute are essential for implementation ScCO technologies to industries. Solubilities 41 compounds correlated by an empirical model, which developed based on the degree freedom analysis. Its correlating ability compared with existing solubility...

Abstract The solubilities of clemastine fumarate in supercritical carbon dioxide (ScCO 2 ) were measured for the first time at temperature (308 to 338 K) and pressure (12 27 MPa). reported terms mole faction (mol/mol total) it had a range from 1.61 × 10 –6 9.41 . Various models used correlate data. efficacy was quantified with corrected Akaike’s information criterion (AICc). A new cluster salvation model derived solubility able data deviation 10.3% average absolute relative (AARD)....

In this study, the solubilities of codeine phosphate, a widely used pain reliever, in supercritical carbon dioxide (SC-CO2) were measured under various pressures and temperature conditions. The lowest determined mole fraction phosphate SC-CO2 was 1.297 × 10-5 at 308 K 12 MPa, while highest 6.502 338 27 MPa. These then modeled using equation state model, specifically Peng-Robinson model. A selection density models, including Chrastil Mendez-Santiago Teja Bartle et al. Sodeifian...

In this study, the solubility of mesalazine in supercritical carbon dioxide with and without cosolvent was carried out for first time at different temperatures pressure values ranging from 308 to 338 K 12 30 MPa, respectively. The determined experimental molar solubilities were range 4.41 × 10-5 9.97 (308 K), 3.9 13.1 (318 3.4 16 (328 K) 3.3 18.4 (338 K). Meanwhile, using 2% dimethyl sulfoxide as 28.22 36.2 26.07 51.41 25.02 69.07 25.86 82.6 A novel association model employed simulate data...

Abstract Solubilities of solid drugs in supercritical fluids were well represented by density models and mathematical models. In literature, several solubility reported, some them observed to be redundant according Gibbs phase rule. Therefore, the present work is aimed address nature recasting existing with help equation state (EoS). Solubility proposed Adachi–Lu, Garlapati–Madras, Keshmiri et al., Si‐Moussa Belghait Sodeifian al. model 1, 2 considered for study. Existing recast versions...

The correlation of adsorption isotherm is crucial for the successful implementation technology. In this work, behavior anionic dyes, eosin Y, and indigo carmine from dilute aqueous solution on chitosan was investigated at T = 303, 313, 323 K P 0.1 MPa through isotherms thermodynamic parameters such as enthalpy change, entropy Gibbs energy. experimental data obtained in study were used to develop a new four-parameter model correlating liquid-phase based solid–liquid phase equilibrium....

Solubility of several anthraquinone derivatives in supercritical carbon dioxide was readily available the literature, but correcting ability existing models poor. Therefore, this work, two new have been developed for better correlation based on solid–liquid phase equilibria. The model has five adjustable parameters correlating solubility isotherms as a function temperature. accuracy proposed evaluated by 25 binary systems. observed provide best overall correlations. deviation between...