A5008448037- Synthesis and biological activity
- ZnO doping and properties
- Synthesis and Characterization of Heterocyclic Compounds
- Metal complexes synthesis and properties
- Organometallic Compounds Synthesis and Characterization
- Click Chemistry and Applications
- Advancements in Solid Oxide Fuel Cells
- Bacteriophages and microbial interactions
- Intermetallics and Advanced Alloy Properties
- Multicomponent Synthesis of Heterocycles
- Synthesis and Biological Evaluation
- Dielectric materials and actuators
- Catalysis and Oxidation Reactions
- Gas Sensing Nanomaterials and Sensors
- Copper-based nanomaterials and applications
- Crystal structures of chemical compounds
- Aluminum Alloys Composites Properties
- X-ray Diffraction in Crystallography
- Ferroelectric and Piezoelectric Materials
- Synthesis of Tetrazole Derivatives
- Computational Drug Discovery Methods
- Advanced materials and composites
- Crystallization and Solubility Studies
- Polymer Nanocomposite Synthesis and Irradiation
- Electronic and Structural Properties of Oxides
University of Southampton
2023-2025
Mangalayatan University
2022-2025
Finnish Society of Sciences and Letters
2024
University of Delhi
2015-2024
Montana State University
2013-2024
University of Helsinki
2024
National Institute of Technology Hamirpur
2023-2024
Guru Gobind Singh Indraprastha University
2024
Washington University in St. Louis
2022-2023
Punjab Engineering College
2018-2022
ABSTRACT Icosahedral viral capsids are obligated to perform a thermodynamic balancing act. Capsids must be stable enough protect the genome until suitable host cell is encountered yet poised bind receptor, initiate entry, navigate cellular milieu, and release their in appropriate replication compartment. In this study, serotypes of adeno-associated virus (AAV), AAV1, AAV2, AAV5, AAV8, were compared with respect physical properties that influence stability. Thermal stability measurements...
Tackling antimicrobial resistance requires the development of new drugs and vaccines. Artificial intelligence (AI) assisted computational approaches offer an alternative to traditionally empirical drug vaccine discovery pipelines. In this mini review, we focus on increasingly important role that AI now plays in vaccines provide reader with methods used identify candidate candidates for selected multi-drug resistant bacteria.
Abstract: Breast cancer remains a critical health concern, requiring continual innovation in treatment to improve patient outcomes. The continuous obstacles therapy and the need for novel techniques underline importance of making advances this discipline. Precision medicine has emerged as viable method, with genomic profiling molecular subtyping allowing targeted based on distinct breast subtypes. This strategy is supplemented by early detection screening, technologies like liquid biopsy...
Chagas disease is a parasitic with approximately 8 million people infected worldwide, presenting limited and toxic treatment. Comprising vast chemodiversity, microbial metabolites are among the most important sources of FDA‐approved anti‐infectives. In this work, bioactivity‐guided fractionation from an extract obtained bacterium Bacillus altitudinis, isolated red seaweed, afforded antitrypanosomal alkaloid which was characterized as (R)‐salsolinol by 1H NMR HR‐ESIMS analysis. showed...
A recently proposed pathway for heme b biosynthesis, common to diverse bacteria, has the conversion of two four propionates on coproheme III vinyl groups as its final step. This reaction is catalyzed in a cofactor-independent, H2O2-dependent manner by enzyme HemQ. Using HemQ from Staphylococcus aureus (SaHemQ), initial decarboxylation step was observed rapidly and obligately yield three-propionate harderoheme isomer intermediate, while slower second appeared control overall rate. Both...
We have developed a dual function carrier using bishexadecyltrimethyl ammonium palladium tetrachloride, which has anticancer as well antibacterial activity, ligand insertion method with simple and easy work procedure. The complex is prepared by cost effective hexadecyltrimethyl chloride under controlled stoichiometry. Herein, we report the aggregation (self assembly) of metallosurfactant having counter ion, in aqueous medium along its binding affinity bovine serum albumin. surfactant...
Chronic hepatitis B virus (HBV) poses a significant public health burden worldwide, encouraging the search for curative antivirals. One approach is capsid assembly modulators (CAMs), which are agonists. CAMs lead to empty and defective capsids, inhibiting formation of new viruses, can also defects in release viral genome, infections. In this study, we employed hydrogen-deuterium exchange mass spectrometry (HDX-MS) assess impact one such CAM, HAP18, on HBV dimers, capsids composed 120 (or 90)...
Bacteria and archaea rely on CRISPR (clustered regularly interspaced short palindromic repeats) RNA-guided adaptive immune systems for sequence specific elimination of foreign nucleic acids. In Escherichia coli, CRISPR-derived RNAs (crRNAs) assemble with Cas (CRISPR-associated) proteins into a 405-kilodalton multisubunit surveillance complex called Cascade (CRISPR-associated antiviral defense). binds DNA complementary to the crRNA guide recruits Cas3, trans-acting nuclease-helicase required...
Pure, and doped with Al/Mn, ZnO nanoparticles were produced by the chemical co-precipitation method. X-ray diffraction analysis confirmed hexagonal crystalline wurtzite structure of pure samples. Williamson-Hall (W-H) was used to determine crystallite size micro-strains. The change in bond length lattice parameters confirms incorporation Al3+ ions interstitial sites Mn2+ substitutional lattice. UV-Visible spectroscopy has been study absorption edge after doping. Dielectric conducting...
A silver based double chained metallosurfactant was synthesized and characterized with various analytical methods. Along the self aggregation behavior, DNA binding abilities of metallomicelles antimicrobial anticancer activities were evaluated.
Cytosolic Ric-8A has guanine nucleotide exchange factor (GEF) activity and is a chaperone for several classes of heterotrimeric G protein α subunits in vertebrates. Using Hydrogen-Deuterium Exchange-Mass Spectrometry (HDX-MS) we show that disrupts the secondary structure Gα Ras-like domain girds nucleotide-binding site, destabilizes interface between Gαi1 Ras helical domains, allowing separation release. These changes are largely reversed upon binding GTP dissociation Ric-8A. HDX-MS...
Abstract Herein, Ni/Co co-doped ZnO nanoparticles (NPs) were successfully prepared via chemical co-precipitation process. The structural, purity and crystallite size of as-prepared particles confirmed by using x-ray diffraction (XRD). results revealed the hexagonal wurtzite structure without any impurity phase samples. decreased from 34.9 to 9.6 nm, whereas lattice strain reduced 0.00086. change in size, parameters, strains dislocation density further indicates successful incorporation...
Vault particles are naturally occurring proteinaceous cages with promising application as molecular containers. The use of vaults functional transporters requires a profound understanding their structural stability to guarantee the protection and controlled payload delivery. Previous results performed bulk techniques or at non-physiological conditions have suggested pH parameter control vault dynamics. Here we Atomic Force Microscopy (AFM) monitor evolution individual while changing in real...