A5026050980- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- Extracellular vesicles in disease
- BRCA gene mutations in cancer
- Gastrointestinal Tumor Research and Treatment
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Nutrition, Genetics, and Disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroendocrine Tumor Research Advances
- HER2/EGFR in Cancer Research
- PI3K/AKT/mTOR signaling in cancer
- Cancer Treatment and Pharmacology
- Mesenchymal stem cell research
- Renal cell carcinoma treatment
University of Palermo
2013-2023
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo
2015-2021
University of Palermo
2014-2021
Antwerp University Hospital
2014-2016
European CanCer Organisation
2015
Background: We investigated whether early dynamic changes of circulating free (cfDNA) levels as well the neutrophil to lymphocyte ratio (NLR) could predict nivolumab effectiveness in pretreated patients with advanced non-small cell lung cancer (NSCLC). Methods: A total 45 receiving 3 mg/kg every 2 weeks were enrolled. Patients underwent a computed tomography scan and responses evaluated by response evaluation criteria solid tumors. Peripheral blood samples obtained from cfDNA level NLR...
The discovery of alterations in the EGFR and ALK genes, amongst others, NSCLC has driven development targeted-drug therapy using selective tyrosine kinase inhibitors (TKIs). To optimize use these TKIs, new biomarkers for early detection disease progression is mandatory. These plasma-isolated exosomes can be used as a non-invasive repeatable way follow-up biomarkers. One ml plasma from 12 patients, with different mutations treatments (and 6 healthy donors controls), were exosome sources....
Background: Lung neuroendocrine carcinoma (NEC) is characterized by aggressive clinical behavior and lack of treatment advances. We evaluate the prognostic predictive roles systemic inflammatory biomarkers in patient circulating blood: neutrophil–lymphocyte ratio (NLR), lactate dehydrogenase (LDH), advanced lung cancer inflammation index (ALI), Immune Prognostic Index (LIPI) score. Methods: A total 120 patients with small-cell (SCLC) ( n = 110) large cell (LCNEC) 10) were enrolled. Overall...
Genetic changes involved in the metaplastic progression from squamous esophageal mucosa toward Barrett's metaplasia and adenocarcinoma are almost unknown. Several evidences suggest that some miRNAs differentially expressed esophagus (BE) adenocarcinoma. Among these, miR-143, miR-145, miR-194, miR-203, miR-205, miR-215 appear to have a key role neoplastic progression. The aim of this study was analyze deregulated serum mucosal tissue biopsies identify new biomarkers could be associated with...
Recent advances in the detection of germline pathogenic variants (PVs)
Background: The advent of immuno-oncology (IO) represented a breakthrough in non-small cell lung cancer (NSCLC) therapy over the last few years. However, establishing optimal therapeutic options among programmed death-ligand 1 (PD-L1) selected subgroups still addresses an unmet need clinical setting.Methods: We performed systematic review and finally included eleven first-line randomized controlled trials to compare efficacy safety outcomes IO treatment strategies versus standard...
Recent studies evaluated the diagnostic accuracy of circulating tumor DNA (ctDNA) analysis in detection epidermal growth factor receptor (EGFR) mutations from plasma NSCLC patients, overall showing a high concordance as compared to standard tissue genotyping. However it is less clear if location metastatic site may influence ability identify EGFR mutations.This pooled aims evaluate association between and sensitivity ctDNA detecting patients.Data all published studies, evaluating...
Previously, it has been reported that hypoxia causes increased mutagenesis and alteration in DNA repair mechanisms. In 2005, an interesting study showed hypoxia-induced decreases BRCA1 expression the consequent suppression of homologous recombination may lead to genetic instability. However, nothing is yet known about involvement BRCA2 hypoxic conditions breast cancer. Initially, a cell proliferation assay allowed us hypothesize could negatively regulate cancer growth short term vitro...