The extended evolutionary synthesis invokes a role for development in shaping adaptive evolution, which population genetics terms corresponds to mutation-biased adaptation. Critics have claimed that clonal interference makes adaptation rare. We consider the behaviour of two simultaneously adapting traits, one with larger mutation rate U, other selection coefficient s, using asexual travelling wave models. find is dominated by whichever trait has faster v isolation, subject stalling....

Abstract Proteins are the workhorses of cell, yet they carry great potential for harm via misfolding and aggregation. Despite dangers, proteins sometimes born de novo from noncoding DNA. more likely to be regions that produce peptides do little no when translated than harmful peptides. To investigate which newborn most “first, harm,” we estimate fitnesses an experiment competed Escherichia coli lineages each expressed a unique random peptide. A variety peptide metrics significantly predict...

Abstract Genetic covariances represent a combination of pleiotropy and linkage disequilibrium, shaped by the population’s history. Observed genetic covariance is most often interpreted in pleiotropic terms. In particular, functional constraints restricting which phenotypes are physically possible can lead to stable G matrix with high variance fitness-associated traits, negative along phenotypic curve constraint. contrast, population models relative fitness assume endless adaptation without...

Abstract The Extended Evolutionary Synthesis invokes a role for development in shaping adaptive evolution, which population genetics terms corresponds to mutation-biased adaptation. Critics have claimed that clonal interference makes adaptation rare. We consider the behavior of two simultaneously adapting traits, one with larger mutation rate U , other selection coefficient s using asexual traveling wave models. find is dominated by whichever trait has faster v isolation, subject...

Abstract Proteins are the workhorses of cell, yet they carry great potential for harm via misfolding and aggregation. Despite dangers, proteins sometimes born de novo from non-coding DNA. more likely to be regions that produce peptides do little no when translated than harmful peptides. To investigate which newborn most “first, harm”, we estimate fitnesses an experiment competed Escherichia coli lineages each expressed a unique random peptide. A variety peptide metrics significantly predict...

Abstract Sebecidae is a clade of large carnivorous crocodyliforms that thrived in the Cenozoic and only lineage diverse terrestrial group Notosuchia survived end-Cretaceous mass extinction event. Sebecus icaeorhinus best-known taxon from this clade, both terms its cranial postcranial anatomy (known primarily holotype specimen MPEF-PV 1776, respectively). Additional material represented by partial skull (MMP 235) has preserved complete choanal region. We describe new information based on an...

ABSTRACT Genetic covariances represent a combination of pleiotropy and linkage disequilibrium, shaped by the population’s history. Observed genetic covariance is most often interpreted in pleiotropic terms. In particular, functional constraints restricting which phenotypes are physically possible can lead to stable G matrix with high variance fitness-associated traits negative along phenotypic curve constraint. contrast, population models relative fitness assume endless adaptation without...