A5075969718- Attention Deficit Hyperactivity Disorder
- Substance Abuse Treatment and Outcomes
- Alcohol Consumption and Health Effects
- Mind wandering and attention
- Functional Brain Connectivity Studies
- Health and Medical Studies
- Neurotransmitter Receptor Influence on Behavior
- Psychiatric care and mental health services
- Cognitive Functions and Memory
- Child and Adolescent Psychosocial and Emotional Development
- Bipolar Disorder and Treatment
- Cardiovascular Syncope and Autonomic Disorders
- Pharmaceutical studies and practices
- Parkinson's Disease Mechanisms and Treatments
- Treatment of Major Depression
- Sleep and related disorders
- Cannabis and Cannabinoid Research
- Workplace Health and Well-being
- Virtual Reality Applications and Impacts
- Identity, Memory, and Therapy
- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural and Behavioral Psychology Studies
- Veterinary Oncology Research
- Neuroinflammation and Neurodegeneration Mechanisms
Goethe University Frankfurt
2018-2024
University Hospital Frankfurt
2018-2024
Central Institute of Mental Health
2011-2022
Heidelberg University
2014-2022
University Hospital Heidelberg
2018-2022
Klinik für Psychosomatik
2015-2021
Fraunhofer Institute for Translational Medicine and Pharmacology
2018
Zentrum für Seelische Gesundheit
2017
Ludwig-Maximilians-Universität München
2010
Adult attention deficit/hyperactivity disorder (ADHD) often co-occurs with substance use disorders (SUD) and is associated early onset more severe development of SUD reduced treatment effectiveness. Screening tools allow for a good recognition possible ADHD in adults should be used routinely, followed by an diagnostic process initiated as soon possible. Simultaneous integrated SUD, using combination pharmaco- psychotherapy, recommended. Long-acting methylphenidate, extended-release...
Abstract Treatment resistance in alcohol use disorders (AUD) is a major problem for affected individuals and society. In the search of new treatment options, few case studies using deep brain stimulation (DBS) nucleus accumbens have indicated positive effects AUD. Here we report double-blind randomized controlled trial comparing active DBS (“DBS-EARLY ON”) against sham (“DBS-LATE over 6 months n = 12 AUD inpatients. This 6-month blind phase was followed by 12-month unblinded period which all...
Background: Childhood attention-deficit/hyperactivity disorder (ADHD) is a risk factor for substance misuse and use (SUD) in adolescence (early) adulthood. ADHD SUD also frequently co-occur treatment-seeking adolescents, which complicates diagnosis treatment associated with poor outcomes. Research on the effect of childhood prevention adolescent inconclusive, studies adolescents are scarce. Thus, available evidence generally not sufficient to justify robust recommendations. Objective: The...
ADAM10 is a metalloproteinase acting on the amyloid precursor protein (APP) as an alpha-secretase in neurons. Its enzymatic activity results secretion of neuroprotective APP cleavage product (sAPP-alpha) and prevents formation amyloidogenic A-beta peptides, major hallmarks Alzheimer's disease (AD). Elevated levels appeared to contribute attenuation A-beta-plaque learning memory deficits AD mouse models. Therefore, it has been assumed that might represent valuable target therapy. Here we...
Objective: ADHD is common in patients with alcohol dependence, but prevalence results are inconsistent. We investigated a complex design to avoid over- or underdiagnosing. Method: Patients dependence starting long-term residential treatment were included. A structured interview (Diagnostic Interview for Adults [DIVA]) was conducted on all patients. DIVA indicating childhood adulthood assessed successive diagnostic interviews by two expert clinicians. Results: 415 of 488 had completed the...
Objectives Sleep disorders are a widespread, persistent problem among alcohol-dependent patients and have been implicated in an increased risk for alcohol relapse. The melatonin-agonist agomelatine has shown to improve overall sleep quality without daytime sedation. Methods In off-label therapeutic setting, 9 with chronic received nightly doses of between 25 50 mg agomelatine. Results After 6 weeks treatment, the Pittsburgh Quality Index global score all had decreased significantly from mean...
Compared to the general population, adult Attention-Deficit / Hyperactivity Disorder (ADHD) is more prevalent in patients with Alcohol Use (AUD). Impaired behavioral inhibition a common characteristic both ADHD and AUD. Relapse risk increased AUD comorbid, untreated neural cue-reactivity.In this study, we examined interaction between correlates of alcohol cue-reactivity hybrid imaging task.Out 69 study participants, included n = 49 our final analyses: Individuals had diagnosis either (n 13),...
Substance use disorders (SUD) often co-occur with attention deficit hyperactivity disorder (ADHD). Although the short-term effects of some specific interventions have been investigated in randomized clinical trials, little is known about long-term course treatment-seeking SUD patients comorbid ADHD.This paper presents protocol and baseline characteristics International Naturalistic Cohort Study ADHD (INCAS) designed conducted by Collaboration on Abuse (ICASA) foundation. The overall aim...
This open-label study in patients with alcohol dependence and evidence of elevated liver stiffness and/or hepatic steatosis was designed to explore the efficacy nalmefene (18 mg) reducing consumption its subsequent effects on a variety clinically relevant parameters.Adult diagnosis (liver >6 kPa or controlled attenuation parameter (CAP) >215 dB/m as measured by transient elastography) were recruited at two sites Germany. During 12-week treatment period, instructed take each day they...
<b><i>Introduction:</i></b> Alcohol dependence (AD) is frequently associated with attention-deficit/hyperactivity disorder (ADHD) as well posttraumatic stress (PTSD). <b><i>Objective:</i></b> Aim of this study was to investigate whether in patients AD, ADHD an increased rate exposure potentially traumatic events (PTEs) and PTSD, PTSD severity higher impact on daily functioning. <b><i>Methods:</i></b> Patients AD were...
More than a decade ago disulfiram lost its approval for use in Germany. Nonetheless, considerable number of psychiatric hospital outpatient departments as well practicing physicians continue to prescribe it. These professionals have formed the "Network Alcohol Aversive Pharmacotherapy" (NAP) maintain high quality this treatment approach.
<b><i>Aims:</i></b> To examine the role of attention deficit/hyperactivity disorder (ADHD) and impulsive personality disorders in nicotine addiction severity among treatment-seeking substance use (SUD) patients. <b><i>Methods:</i></b> In a cross-sectional study, we examined data from second <i>International ADHD Substance Use Disorders Prevalence Study</i> (<i>IASP-2</i>) on 402 adults SUD treatment Puerto Rico, Hungary,...
A link between attention-deficit/hyperactivity disorder (ADHD) and alcohol use (AUD) has been widely demonstrated. In this study, we used neuroimaging to investigate the connectivity traits that may contribute comorbidity of these disorders.The study included an AUD group (N = 18), ADHD 17), a with + 12) control 18). We resting-state functional in seed-based approach default mode networks, dorsal attention network, salience network.Within all affected groups shared greater toward temporal...
Rationale: Both attention deficit-/hyperactivity disorder (ADHD) and alcohol use (AUD) are accompanied by deficits in response inhibition. Furthermore, the prevalence of comorbidity ADHD AUD is high. However, there a lack research on whether same neuronal subprocesses inhibition (i.e., interference inhibition, action withholding cancellation) exhibit both psychiatric disorders. Methods: We examined these three neural patient groups healthy controls: non-medicated individuals with (ADHD; N =...
Increasing evidence shows that unintentional mind wandering is linked to Attention Deficit Hyperactivity Disorder (ADHD) and its frequency contributes symptom severity functional impairment in ADHD. However, empirical data on adult ADHD are still scarce, a validated scale assess German patients lacking. The primary aim of this study the psychometric properties version recently published Mind Excessively Wandering Scale (MEWS-G) terms factorial structure factor stability, internal consistency...
Abstract Background: Treatment of attention-deficit/ hyperactivity disorder (ADHD) in patients with a substance use (SUD) and comorbid ADHD (SUD +ADHD) may have positive effects on the outcome both conditions, but controversy exists regarding preferred treatment these patients. Little is known about treatments that are provided for routine addiction care practice factors associated provision. Objective: To describe everyday clinical to explore provision SUD +ADHD. Methods: An international...
Rationale Attention deficit/hyperactivity disorder (ADHD) is common in alcohol use (AUD). Continuous performance tests (CPTs) allow to measure ADHD related deficits a laboratory setting. Most studies on this topic focused CPTs measuring inattention or impulsivity, disregarding hyperactivity as one of the core symptoms ADHD. Methods We examined N = 47 three groups (ADHD 19; AUD 16; + 12) with questionnaires symptoms, executive functioning (EF), mind wandering, and quality life (QoL). 46 14)...
International Consensus Statement for the Screening, Diagnosis, and Treatment of Adolescents with Concurrent Attention-Deficit/Hyperactivity Disorder Substance Use Abstract.Background: Childhood attention-deficit/hyperactivity disorder (ADHD) is a risk factor substance misuse use (SUD) in adolescence (early) adulthood. ADHD SUD also frequently co-occur treatment-seeking adolescents, which complicates diagnosis treatment associated poor outcomes. Research on effect childhood prevention...