A5046708392- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Genetic and Kidney Cyst Diseases
- Genetic Syndromes and Imprinting
- Renal and related cancers
- Hallucinations in medical conditions
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Psychedelics and Drug Studies
University of Manchester
2018
University of Kansas Medical Center
2018
Toll-like receptor (TLR) signaling regulates macrophage activation and effector cytokine propagation in the constrained environment of a tissue. In populations, TLR4 stimulates dose-dependent transcription nuclear factor κB (NF-κB) target genes. However, using single-RNA counting, we found that individual cells exhibited wide range (three orders magnitude) expression gene encoding proinflammatory tumor necrosis factor-α (TNF-α). The TLR4-induced TNFA transcriptional response correlated with...
Polycystic kidney disease (PKD) is a genetic disorder characterized by fluid-filled cysts in the and liver that ultimately leads to end-stage renal disease. Currently there no globally approved therapy for PKD. The Notch signaling pathway regulates cellular processes such as proliferation de-differentiation, which are hallmarks of Thus we hypothesized plays critical role Evaluation protein expression components kidneys Autosomal Recessive PKD (ARPKD) Dominant (ADPKD) mouse models ADPKD...
Stroboscopic (strobe) hallucinations are geometric percepts elicited by flickering full-field illumination at specific frequencies. They bear a striking resemblance to the kaleidoscopic imagery induced hallucinogenic psychedelics. As such, they have potential serve as an experimental model for studying these altered states of consciousness in controlled manner. However, it remains unclear if similar perceptual experiences share same underlying neural correlates. To address this question, we...