A5071226824- Optical Coherence Tomography Applications
- Retinal and Macular Surgery
- Pain Mechanisms and Treatments
- Astrophysics and Star Formation Studies
- Retinal Diseases and Treatments
- Photoacoustic and Ultrasonic Imaging
- Superconducting and THz Device Technology
- Advanced Fiber Laser Technologies
- Computer Graphics and Visualization Techniques
- Stellar, planetary, and galactic studies
- Cardiac Arrest and Resuscitation
- Advanced Fluorescence Microscopy Techniques
- 3D Shape Modeling and Analysis
- Spectroscopy Techniques in Biomedical and Chemical Research
- Mechanical Circulatory Support Devices
- Pain Management and Placebo Effect
- Atmospheric Ozone and Climate
- Spectroscopy and Laser Applications
- Advanced Vision and Imaging
- Renal Transplantation Outcomes and Treatments
- Glaucoma and retinal disorders
- Semiconductor materials and devices
- Astronomy and Astrophysical Research
- Advanced Thermodynamic Systems and Engines
- Musculoskeletal pain and rehabilitation
Inserm
2020-2025
Centre de Médecine Préventive
2020-2025
Université de Lorraine
2020-2025
Centre Cardiologique du Nord
2025
Centre Hospitalier Régional et Universitaire de Nancy
2021-2025
University of Tübingen
2023-2024
Max Planck Institute for Intelligent Systems
2023-2024
Universitätsklinikum Würzburg
2024
Défaillance Cardiovasculaire Aiguë et Chronique
2022-2023
Nationales Centrum für Tumorerkrankungen Dresden
2023
We present ultra high speed optical coherence tomography (OCT) with multi-megahertz line rates and investigate the achievable image quality. The presented system is a swept source OCT setup using Fourier domain mode locked (FDML) laser. Three different FDML-based laser sources sweep of 1, 2.6 5.2MHz are compared. Imaging 4 spots in parallel quadruples effective speed, enabling depth scan as 20.8 million lines per second. Each provides at least 98dB sensitivity approximately 10microm...
Long-term potentiation (LTP) and long-term depression (LTD) of synaptic strength are ubiquitous mechanisms plasticity, but their functional relevance in humans remains obscure. Here we report that a increase perceived pain to electrical test stimuli was induced by high-frequency stimulation (HFS) (5 × 1 sec at 100 Hz) peptidergic cutaneous afferents (27% above baseline, undiminished for >3 hr). In contrast, decrease below hr) low-frequency (LFS) (17 min Hz). Pain testing with punctate...
We demonstrate ultrahigh speed swept source retinal OCT imaging using a Fourier domain mode locked (FDML) laser. The laser uses combination of semiconductor optical amplifier and an ytterbium doped fiber to provide more than 50 mW output power. 1050 nm FDML standard telecom for the km long delay line instead two orders magnitude expensive real single fiber. investigate influence this "oligo-mode" on performance. Two design configurations with 684,400 1,368,700 axial scans per second are...
We analyze the benefits and problems of in vivo optical coherence tomography (OCT) imaging human retina at A-scan rates excess 1 MHz, using a 1050 nm Fourier-domain mode-locked (FDML) laser. Different scanning strategies enabled by MHz OCT line are investigated, simple multi-volume data processing approach is presented. In-vivo ocular fundus performed different axial scan up to 6.7 MHz. High quality non-mydriatic retinal over an ultra-wide field achieved combination several key improvements...
The efficacy and safety of zanamivir, administered 2× or 4× daily over 5 days, was evaluated in the treatment influenza infections. A total 1256 patients entered study; 57% those randomized had laboratory-confirmed infection. primary end point, "alleviation major symptoms," created to evaluate differences clinical impact. In overall population with without infection, zanamivir reduced median number days reach this point by 1 day (P = .012 vs. placebo; P .014 placebo). reduction greater...
Patients with sensory disturbances of painful and non-painful character show distinct changes in touch and/or pain sensitivity. The patterns were compared to those human surrogate models neuropathic assess the underlying mechanisms. We investigated 30 consecutive in-patients dysaesthesia various origins (peripheral, spinal, brainstem lesions) 15 healthy subjects. Tactile thresholds determined calibrated von Frey hairs (1.1mm). Thresholds stimulus-response functions for pricking a series...
In this work we present a flexible framework for GPU-based volume rendering. The is based on single pass raycasting approach and easily extensible in terms of new shader functionality. We demonstrate the flexibility our system by means number high-quality standard non-standard rendering techniques. Our implementation shows promising performance benchmarks while producing images higher accuracy than obtained pre-integrated slice-based
We present a 1300 nm OCT system for volumetric real-time live acquisition and visualization at 1 billion volume elements per second.All technological challenges problems associated with such high scanning speed are discussed in detail as well the solutions.In one configuration, acquires, processes visualizes 26 volumes second where each consists of 320 x depth scans scan has 400 usable pixels.This is fastest to date terms voxel rate.A 51 Hz rate realized half frame number.In both...
Injection of hypertonic saline into deep tissues the back (subcutis, muscle, or surrounding fascia) can induce acute low pain (LBP). So far, no study has analyzed differences in temporal, qualitative, and spatial characteristics originating from these tissues. The current aimed to investigate role thoracolumbar fascia as a potential source LBP. In separate sessions, 12 healthy subjects received ultrasound-guided bolus injections isotonic (0.9%) (5.8%) erector spinae (posterior layer),...
We evaluate strategies to maximize the field of view (FOV) in vivo retinal OCT imaging human eyes. Three modes are tested: Single volume with 85° FOV as well 100° and stitching five 60° images a mosaic (measured from nodal point). employ MHz-OCT system based on 1060nm Fourier domain mode locked (FDML) laser depth scan rate 1.68MHz. The high speed is essential for dense isotropic sampling large areas. Challenges caused by wide discussed solutions most issues presented. Detailed information...
Long-term potentiation in the spinal dorsal horn requires peptidergic C-fibre activation animals. Perceptual correlates of long-term following high-frequency electrical stimulation humans include increased sensitivity to stimuli at high frequency site (homotopic pain–long-term potentiation) and pinprick surrounding (heterotopic potentiation, equivalent secondary hyperalgaesia). To characterize peripheral fibre populations involved induction we performed two selective nerve block experiments...
Retinal and choroidal vascular imaging is an important diagnostic benefit for ocular diseases such as age-related macular degeneration. The current gold standard vessel visualization fluorescence angiography. We present a potential non-invasive alternative to image blood vessels based on functional Fourier domain optical coherence tomography (OCT). For OCT compete with the field of view resolution angiography while maintaining motion artifacts minimum, ultrahigh-speed has be introduced....
Raman sensing and microscopy are amongst the most specific optical technologies to identify chemical compounds of unknown samples, enable label-free biomedical imaging with molecular contrast. However, high cost complexity, low speed, incomplete spectral information provided by current technology major challenges preventing more widespread application systems. To overcome these limitations, we developed a new method for stimulated spectroscopy using continuous wave (CW), rapidly wavelength...
Abstract As an indirect approach to relate previously identified sensory phenotypes of patients suffering from peripheral neuropathic pain underlying mechanisms, we used a published sorting algorithm estimate the prevalence denervation, and central sensitization in 657 healthy subjects undergoing experimental models nerve block (NB) (compression topical lidocaine), primary hyperalgesia (PH) (sunburn capsaicin), or secondary (intradermal capsaicin electrical high-frequency stimulation), 902...
Acral burning pain triggered by fever, thermal hyposensitivity and skin denervation are hallmarks of small fibre neuropathy in Fabry disease, a life-threatening X-linked lysosomal storage disorder. Variants the gene encoding alpha-galactosidase A may lead to impaired enzyme activity with cellular accumulation globotriaosylceramide. To study underlying pathomechanism Fabry-associated neuropathy, we generated neuronal
In this work we present a flexible framework for GPU-based volume rendering. The is based on single pass raycasting approach and easily extensible in terms of new shader functionality. We demonstrate the flexibility our system by means number high-quality standard nonstandard rendering techniques. Our implementation shows promising performance benchmarks while producing images higher accuracy than obtained pre-integrated slice-based
Electrical high-frequency stimulation (HFS) of skin afferents elicits long-term potentiation (LTP)-like hyperalgesia in humans. Time courses were evaluated the facilitating (homotopic) or facilitated (heterotopic) pathways to delineate relative contributions early late LTP-like pain plasticity. HFS healthy subjects (n = 55) elicited highly significant increases electrical stimuli via conditioning electrode (to 145% control, homotopic LTP) and pinprick adjacent 190% secondary hyperalgesia)....
We report on the effect of chromatic dispersion coherence length and noise Fourier Domain Mode Locked (FDML) lasers. An FDML laser with a sweep range 100 nm around 1550 has been investigated. Cavity configurations without compensation have analyzed using different widths intra-cavity optical band-pass filter. The measurements are compared to non-FDML wavelength swept sources. Based these observations, simple model is developed providing connection between timing, photon cavity lifetime...
We present a 1300 nm Fourier domain mode locked (FDML) laser for optical coherence tomography (OCT) that combines both, high 1.6 MHz wavelength sweep rate and an ultra-long instantaneous length rapid volumetric deep field imaging. By reducing the dispersion in fiber delay line of FDML laser, hence available imaging range is approximately quadrupled compared to previously published MHz-FDML setups, speed increased by factor 16 previous extended results. detailed characterization performance....
Background— Innervation is a critical component of arrhythmogenesis and may present an important trigger/substrate modifier not used in current ventricular tachycardia (VT) ablation strategies. Methods Results— Fifteen patients referred for ischemic VT underwent preprocedural cardiac 123 I- meta -iodobenzylguanidine ( m IBG) imaging, which was to create 3-dimensional (3D) innervation models registered high-density voltage maps. 3D IBG maps demonstrated areas complete denervation transition...
We present the upGREAT THz heterodyne arrays for far-infrared astronomy. The Low Frequency Array (LFA) is designed to cover 1.9-2.5 range using 2x7-pixel waveguide-based HEB mixer in a dual polarization configuration. High (HFA) will perform observations of [OI] line at ~4.745 7-pixel array. This paper describes common design both arrays, cooled 4.5 K closed- cycle pulse tube technology. then show laboratory and telescope characterization first array with its 14 pixels (LFA), which...
Fibromyalgia syndrome (FMS) is a chronic widespread pain condition probably comprising subgroups with different underlying pathomechanisms. There increasing evidence for small nerve fiber impairment in of patients FMS. MicroRNAs (miRNAs) regulate molecular factors determining de- and re-generation. We investigated whether systemic cutaneous miRNA expression FMS related to pathology. confirmed previous findings disturbed function reduced intraepidermal density found 51 aberrantly expressed...