A5018729995- Adipose Tissue and Metabolism
- Cardiovascular Function and Risk Factors
- Cardiovascular and exercise physiology
- Mitochondrial Function and Pathology
- Genetics and Physical Performance
- Muscle metabolism and nutrition
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Heart Failure Treatment and Management
- Pancreatic function and diabetes
- Electrochemical sensors and biosensors
- Exercise and Physiological Responses
- Enzyme-mediated dye degradation
- Infective Endocarditis Diagnosis and Management
- Diabetes Treatment and Management
- ATP Synthase and ATPases Research
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Pain Management and Treatment
- Cardiac Ischemia and Reperfusion
- Nutrition and Health in Aging
- Metabolism and Genetic Disorders
- Cardiomyopathy and Myosin Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Growth Hormone and Insulin-like Growth Factors
Friedrich Schiller University Jena
2018-2023
Jena University Hospital
2018-2023
In heart failure, high-fat diet (HFD) may exert beneficial effects on cardiac mitochondria and contractility. Skeletal muscle mitochondrial dysfunction in failure is associated with myopathy. However, it not clear if HFD affects skeletal as well. To induce we used pressure overload (PO) rats fed normal chow or HFD. Interfibrillar (IFM) subsarcolemmal (SSM) from gastrocnemius were isolated functionally characterized. With PO maximal respiratory capacity was impaired IFM but increased SSM of...
Ubiquinol cytochrome c reductase hinge protein (UQCRH) is required for the electron transfer between c1 and of mitochondrial bc1 Complex (CIII). A two-exon deletion in human UQCRH gene has recently been identified as cause a rare familial disorder. Deletion corresponding mouse (Uqcrh-KO) resulted striking biochemical clinical similarities including impairment CIII, failure to thrive, elevated blood glucose levels, early death. Here, we set out test how global ablation murine Uqcrh affects...
Exercise capacity of an individual describes the ability to perform physical activity. This exercise is influenced by intrinsic factors such as genetic constitution and extrinsic training. On metabolic level metabolism are linked. As important site main source for ATP needed muscle contraction, mitochondrial function can determine capacity, inversely influences function. It has been suggested that mediates many its effects due changes. Although affect a major part individual's genetically...
Abstract Background Current expert consensus suggests modulation of cardiac glucose oxidation (GO) or fatty acid (FAO) as a therapeutic approach for heart failure (HF). However, inconsistency exists and there is no systematic evidence supporting this concept. Objective We conducted review preclinical studies to assess the role metabolic treatment in HF. aimed identify, via meta-analytic techniques, specific strategies that potentially improve function. Methods searched PubMed, Web Science...
The antitumor treatment NVP-AEW541 blocks IGF-1R. IGF-1R signaling is crucial for cardiac function, but the effects of are ill defined. We assessed NVP-AEW541's on function and insulin response in vivo isolated working hearts. performed a dose-response analysis male, 3-week-old rats chronic clinically relevant dose adult rats. glucose tolerance tests echocardiography; expression phosphorylation InsR/IGF-1R Akt vivo; measured substrate oxidation, contractile caused dose-dependent growth...
Aerobic exercise capacity is inversely related to morbidity and mortality as well insulin resistance. However, exercising in patients has led conflicting results, presumably because aerobic consists of intrinsic (genetically determined) extrinsic (environmentally parts. The contribution both parts sensitivity also not clear. We investigated sedentary exercised (aerobic interval training) high-capacity runners (HCR) low-capacity (LCR) differing their genetically determined determine the...
Background: Aerobic exercise capacity is in large parts genetically determined. In an established rat model of high (HCR) and low (LCR) determined, intrinsic capacity, the rat's performance on a treadmill differs by factor up to eight. these rats, related higher mitochondrial respiration rates associated with ROS production. We thus assessed corresponding antioxidative hearts HCR LCR its adaption additional training.
Background: Rats selectively bred for low (LCR) and high intrinsic exercise capacity (HCR) show phenotype-differences. Some studies suggest that this individual is related to cardiovascular disease it may also affect surgical outcomes. Since function associated with mitochondrial we assessed the influence of genetic predisposition on in LCR HCR without aerobic interval training (AIT).
Background: Insulin resistance is associated with impaired mitochondrial function in skeletal muscle and a potential cause for the adverse effects of diabetes, well-known risk factor cardiac surgery. However, two populations mitochondria exist it not known whether both them are affected equally. We thus aimed to assess effect high fat diet on interfibrillar (IFM) subsarcolemmal (SSM) mitochondria.
Background: Ischemia/reperfusion (I/R) and pressure overload (PO) represent potentially detrimental stresses to the heart. Exercise capacity is considered protective against cardiovascular disease improving survival. We tested how intrinsic (i.e., genetically determined) exercise influences stress resistance. used model of high (HCR) or low (LCR) rats for tolerance cardiac stress.
Objectives: Diabetes causes mitochondrial dysfunction representing an important pathomechanism in the development of heart failure and affecting surgical outcome. Metformin is a first-line treatment diabetic failure, confers survival benefit under certain stress conditions recommended for use cardiac surgery. However, it not clear how influences function. We thus investigated function different organs model diabetes (high fat diet fed rats) compared to healthy controls normal chow assess...
Objectives: Inhibition of insulin-like growth factor (IGF-1) receptor has recently become a treatment strategy in oncology for the suppression and survival many tumor types. However, IGF-1 signaling is crucial cardiac function. In this study, we evaluated effect an inhibition (IGF-1R) concomitant insulin (InR) on function glucose metabolism.
Objectives: Sepsis is a systemic inflammatory reaction that may lead to multiple organ failure and death. Sepsis-induced cardiac dysfunction represents one important complication coresponsible for the high mortality typical sepsis. Physical fitness, as well high-intrinsic exercise capacity positively, influences cardiovascular health. However, less known about impact of these factors on performance metabolism in We aimed identify effect sepsis function, insulin responsiveness rats differing...
Objectives: Low exercise capacity is considered a risk factor for cardiovascular disease and increased mortality. Both, cardiac function are related to mitochondrial physical fitness has been found protective also in heart failure. We assessed the effect of high or low on survival, with pressure overload.