A5100374130- Neuroendocrine regulation and behavior
- Child and Animal Learning Development
- Neuroscience of respiration and sleep
- Bat Biology and Ecology Studies
- Receptor Mechanisms and Signaling
- Autism Spectrum Disorder Research
Capital Medical University
2019-2023
Peking University
2019
Chinese Institute for Brain Research
2019
Mutations within the Shank3 gene, which encodes a key postsynaptic density (PSD) protein at glutamatergic synapses, contribute to genetic etiology of defined autism spectrum disorders (ASDs), including Phelan-McDermid syndrome (PMS) and intellectual disabilities (ID). Although there are series mouse models study gene in ASDs, few rat with species-specific advantages. In this study, we established characterized novel model deletion spanning exons 11-21 Shank3, leading complete loss major...