A5022214167- Cancer Research and Treatments
- Genital Health and Disease
- Nonmelanoma Skin Cancer Studies
- Cutaneous Melanoma Detection and Management
- Virus-based gene therapy research
- Nanoplatforms for cancer theranostics
- Diagnosis and Treatment of Venous Diseases
- Urological Disorders and Treatments
- Nail Diseases and Treatments
- Spanish Linguistics and Language Studies
- Hidradenitis Suppurativa and Treatments
- Syphilis Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Urologic and reproductive health conditions
- Fungal Infections and Studies
- Wound Healing and Treatments
- Cancer and Skin Lesions
- Melanoma and MAPK Pathways
- Cutaneous lymphoproliferative disorders research
- Autoimmune and Inflammatory Disorders
- Autophagy in Disease and Therapy
- Musculoskeletal synovial abnormalities and treatments
- Sirtuins and Resveratrol in Medicine
- Female Genital Mutilation/Cutting Issues
- Oral Health Pathology and Treatment
Hospital de Clínicas
2007-2021
Universidad de la República
2009-2021
Systemic administration of cytokines has shown therapeutic benefits in cancer patients; however, serious adverse effects associated with direct protein prevent the wide use this approach. We have assessed capacity live attenuated Salmonella to act as a vector for oral cytokine-gene therapy. orally administered melanoma-bearing mice was found accumulate within tumor, reaching up 10(5) bacteria per gram tumor by day 21 after bacterial inoculation. Numbers recovered from did not differ those...
Abstract Cellular senescence is an endpoint of chemotherapy, and targeted therapies in melanoma the senescence-associated secretory phenotype (SASP) can affect tumor growth microenvironment, influencing treatment outcomes. Metabolic interventions modulate SASP, enhanced mitochondrial energy metabolism supports resistance to therapy cells. Herein, we assessed function therapy-induced senescent cells obtained after exposing temozolomide (TMZ), a methylating chemotherapeutic agent. Senescence...
We evaluated a novel approach combining the use of attenuated Salmonella immunotherapy with Toll-like receptor agonist, imiquimod, in B16F1 melanoma-bearing mice.B16F1 mice were daily treated topical imiquimod combination one intratumoral injection enterica serovar Typhimurium LVR01.The combined therapy resulted retarded tumor growth and prolonged survival. Combination treatment led to an enhancement expression pro-inflammatory cytokines chemokines microenvironment, Th1-skewed profile,...
Evaluation of the Charing Cross VenousUlcer Questionnaire in patients with chronic venous ulcers UruguayBackground: Chronic (CVU) represent a frequent condition, difficult therapeutic approaches, that impact on patients' quality life, and generate an economic burden to health systems.Aim: To perform cultural adaptation initial evaluation Venous Ulcer (CCVUQ) for Uruguay, study health-related life (HRQL) CVU.Material Methods: The translated culturally adapted version CCVUQ was applied...
When possible, surgery is the treatment of choice for cutaneous carcinomas, as it allows to us perform anatomopathological study and control surgical margins. Mohs micrographic (MMS) controls 100% margins, maintains a larger amount healthy tissue, fewer number recurrences are seen. Large limb defects after MMS challenge. Within different kind flaps, keystone flap, which fasciocutaneous island advancement an option.A descriptive was carried out on extremity that occurred MMS, were...
Ultrapotent topical corticosteroids and circumcision are usually effective for male genital lichen sclerosus (MGLSc); however, refractory cases often referred to our Male Genital Dermatology Unit. Treatment with autologous platelet-rich plasma (TPRP) has recently been advocated as a safe treatment option, but there have no prospective studies in men date. The objective of this study is assess the safety efficacy TPRP MGLSc resistant conventional therapy. A prospective, open-label,...
Ingrown nails are a common problem, seen mostly in young adults. Also known as onychcrypotisis, this condition typically affects the great toenail. Four stages have been defined according to severity and duration of condition, treatment varies from conservative surgical techniques depending on stage. We present our experience with describing characteristics population treatment, particular super U technique. This was retrospective, descriptive study patients ingrown toenail treated...
Antecedentes: El Cardiff Acne Disability Index (CADI) es una herramienta específica para la medición del impacto en calidad de vida los pacientes con acné, que ha sido traducido y validado a diversos idiomas. Objetivo: Presentar versión definitiva español Uruguay cuestionario CADI su proceso validación. Material métodos: La traducción original inglés se realizó siguiendo recomendaciones internacionales, incluyendo por varios profesionales, retrotraducción al un posterior testeo...
Background: The Cardiff Acne Disability Index (CADI) is a specific tool for measuring the impact on quality of life patients with acne, and has been translated validated into multiple languages. Objective: We present definitive Uruguayan Spanish version CADI questionnaire, its validation process. Material methods: translation from original in English was carried out following international recommendations, including by several professionals, back-translation English, subsequent...
Penile sclerosing granuloma is a foreign body reaction to the injection of material, usually for genital augmentation purposes. Patients commonly deny having had or performed these procedures on themselves, and diagnosis can be challenging. We describe case 62-year-old man with 10-year history growth penile shaft. Dermoscopic examination showed an orange background shiny white structures, suggesting granulomatous pathology. Guided biopsies confirmed lipogranuloma. The patient admitted...
An otherwise healthy 23-year-old man presented to our male genital dermatology unit with an 8-week history of sudden postcoital appearance a preputial growth ([figure 1A][1]). This asymptomatic lesion had fibroelastic consistency. Dermoscopic examination showed translucent, structureless skin