A5068794327- Vasculitis and related conditions
- Cell Adhesion Molecules Research
- Cancer-related cognitive impairment studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammasome and immune disorders
- Cancer survivorship and care
- Otitis Media and Relapsing Polychondritis
- CAR-T cell therapy research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Parvovirus B19 Infection Studies
- Lung Cancer Research Studies
- Family Support in Illness
- Mesenchymal stem cell research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- 3D Printing in Biomedical Research
- Microtubule and mitosis dynamics
- Mast cells and histamine
- Angiogenesis and VEGF in Cancer
- Biosimilars and Bioanalytical Methods
- Urticaria and Related Conditions
- Sarcoidosis and Beryllium Toxicity Research
- Biomedical Ethics and Regulation
- Advanced Breast Cancer Therapies
- Single-cell and spatial transcriptomics
- Ocular Surface and Contact Lens
University of Groningen
2007-2013
University Medical Center Groningen
2007-2013
The concomitant use of CDK4/6 inhibitors with cytotoxic agents may prevent chemotherapy-induced bone marrow exhaustion in cancer patients.
The involvement of autoantibodies to human lysosome-associated membrane protein-2 (hLAMP-2) in anti–neutrophil cytoplasmic antibody (ANCA)–associated vasculitis is controversial because the absence confirmatory data subsequent initial reports their high prevalence this disease. We characterized three assays for anti-hLAMP-2 antibodies: ELISA and Western blotting using unglycosylated recombinant hLAMP-2 expressed Escherichia coli, an indirect immunofluorescence assay stably transfected ldlD...
Objectives. CpG motifs, which are highly prevalent in bacterial DNA, have been shown to trigger the production of ANCA vitro by B lymphocytes from patients with active ANCA-associated vasculitis (AAV). Staphylococcus aureus is associated relapses AAV, and motifs staphylococcal DNA may AAV remission. We investigated presence ANCA-producing during quiescent disease tested capacity these cells produce response CpG. Methods. Expression Toll-like receptor 9 (TLR9) controls was assessed....
Introduction Toll-like receptors (TLRs) are a family of that sense pathogen associated patterns such as bacterial cell wall proteins. Bacterial infections with anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV). Here, we assessed the expression TLRs 2, 4, and 9 by peripheral blood leukocytes from patients AAV, investigated TLR mediated responses ex vivo. Methods Expression was determined in 38 AAV (32 remission, 6 active disease), 20 healthy controls (HC). Membrane 9,...
Abstract Introduction The present study aimed to explore a possible role for IL-21 producing Th-cells in the immunopathogenesis of granulomatosis with polyangiitis (GPA). Methods Peripheral blood from 42 GPA patients remission and 29 age-matched healthy controls (HCs) were stimulated vitro , frequencies determined by flow cytometry. Since Th17-cells produce low level IL-21, IL-17 was also included analysis. Given that is hallmark cytokine T follicular helper cells (T FH ), we next evaluated...
The etiology of anti-neutrophil cytoplasmic antibodies (ANCA) associated vasculitides (AAV) is unknown, but the association between infections and autoimmunity has been studied extensively. In 2004, a novel theory was proposed that could link infection autoimmunity. This 'theory autoantigen complementarity' based on serendipitous finding against complementary-PR3 (cPR3) in patients with PR3-ANCA-associated vasculitis. cPR3 demonstrated homology to several bacterial proteins, it hypothesized...
In vivo vascularization of implanted (bio)artificial constructs is essential for their proper function. Vascularization may rely on sprouting angiogenesis, vascular incorporation bone marrow-derived endothelial cells (BMDECs), or both. Here we investigated the relative contribution these 2 mechanisms to neovascularization in a mouse model foreign body reaction (FBR) subcutaneously Dacron and hind limb ischemia (HLI) relation molecular microenvironment at sites. Neovascularization was studied...
2529 Background: Myelosuppression is the major dose-limiting toxicity of chemotherapy, which limits dose intensity. G1T28 a highly potent and selective CDK4/6 inhibitor in development as an IV agent to provide targeted bone marrow chemoprotection patients with CDK4/6-independent tumors. Hematopoietic stem progenitor cells (HSPCs) are dependent upon for proliferation; induces transient G1 cell cycle arrest that renders HSPCs resistant cytotoxic effects chemotherapy. In preclinical models,...