A5091073360- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Anesthesia and Neurotoxicity Research
- Nuclear Receptors and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Cannabis and Cannabinoid Research
- Neurogenesis and neuroplasticity mechanisms
- Neurological diseases and metabolism
- Brain Metastases and Treatment
- Neonatal and fetal brain pathology
- Pain Mechanisms and Treatments
- Pharmacological Receptor Mechanisms and Effects
- Neuroscience of respiration and sleep
- Adenosine and Purinergic Signaling
- Biochemical effects in animals
- Stress Responses and Cortisol
Georgetown University
2015-2019
Georgetown University Medical Center
2017
State Key Laboratory of Biotherapy
2015
Sichuan University
2015
Summary Objective Phenobarbital is the most commonly utilized drug for treatment of neonatal seizures. The use phenobarbital continues despite growing evidence that it exerts suboptimal seizure control and associated with long‐term alterations in brain structure, function, behavior. Alterations following exposure include acute induction neuronal apoptosis, disruption synaptic development striatum, a host behavioral deficits. These deficits those learning memory mediated by hippocampus....
Abstract Microglia are in a privileged position to both affect and be affected by neuroinflammation, neuronal activity injury, which all hallmarks of seizures the epilepsies. Hippocampal microglia become activated after prolonged, damaging known as status epilepticus (SE). However, since SE causes hyperactivity injury neurons, mechanisms triggering this activation remain unclear, does relevance microglial ensuing epileptogenic processes. In study, we use electroconvulsive shock (ECS) study...
Abstract Dopamine ( DA ) is a potent neuromodulator known to influence glutamatergic transmission in striatal medium spiny neurons MSN s). It acts on D1‐ and D2‐like receptors that are expressed two distinct subpopulations. s projecting the substantia nigra express D1 (D1Rs), while those lateral globus pallidus D2 (D2Rs). D1R signalling particular can increase excitatory through varied protein kinase A‐dependent, cell‐autonomous pathways. Mechanisms by which could D2R‐bearing have been...
Neuroinflammation precedes neuronal loss in striatal neurodegenerative diseases and can be exacerbated by the release of proinflammatory molecules microglia. These affect trafficking AMPARs. The preferential calcium-permeable versus impermeable AMPARs result disruptions [Ca