A5082524051- Advanced Sensor and Energy Harvesting Materials
- Polymer Surface Interaction Studies
- Conducting polymers and applications
- Ocular Surface and Contact Lens
- Advanced Drug Delivery Systems
- Glaucoma and retinal disorders
- Tactile and Sensory Interactions
- Ferroelectric and Piezoelectric Materials
- Surfactants and Colloidal Systems
- Bacterial biofilms and quorum sensing
- Bone Tissue Engineering Materials
- Obstructive Sleep Apnea Research
- Antimicrobial agents and applications
- Cystic Fibrosis Research Advances
- Tracheal and airway disorders
- Hearing Loss and Rehabilitation
- Electrospun Nanofibers in Biomedical Applications
University of Iowa
2019-2025
Brigham Young University
2017-2019
To determine the effects of zwitterionic hydrogel films on mucus contact angles, flow, and stasis with respect to medical polymer surfaces, both flat tubular. A thin film was photografted onto rubber surfaces compared against non-zwitterionic untreated its impact flow sheets tubes, plugging. Zwitterionic conventional significantly reduce angles tilt required initiate in tubular systems. Preliminary experiments show that these may also shorten time for a mucus-plugged tube unplug when exposed...
Zwitterionic polymer networks have shown promise in reducing the short- and long-term inflammatory foreign body response to implanted biomaterials by combining antifouling properties of zwitterionic polymers with mechanical stability provided cross-linking. Cross-link density directly modulates (i.e., swelling behavior, resistance stress strain, lubricity) but theoretically could reduce desirable biological antifouling) materials. This work examined effect varying poly(ethylene glycol)...
Due to its attractive mechanical properties and biocompatibility, poly(dimethyl)siloxane (PDMS) is widely used in the fabrication of biomedical materials. On other hand, PDMS also prone adsorption both proteins bacteria, making implants susceptible infection. Herein, we examine use durably cross-linked zwitterionic coatings for surfaces mitigate bacterial adhesion. Using a single-step photografting technique, poly(sulfobetaine methacrylate) (pSBMA) poly(carboxybetaine (pCBMA) thin films were...
This study investigated the potential of delivering an anti-glaucoma drug using commercial silicone hydrogel (SiHy) contact lenses. The moderately hydrophobic latanoprost was rapidly loaded in 4 min by swelling lenses a solution n-propanol. A fraction radiolabeled, thus allowing measurement uptake and subsequent release into artificial tear fluid. Three questions were addressed: (1) how much can be each type lens, (2) fast is release, (3) are these values related to lens chemistry. results...
Hypothesis: Application of photografted zwitterionic coatings to cochlear implant (CI) biomaterials will reduce friction and insertion forces. Background: Strategies minimize intracochlear trauma during implantation an electrode array are critical optimize outcomes including preservation residual hearing. To this end, advances in thin-film hydrogel on relevant may show promise, addition the potential these materials for decreasing foreign body response. Methods: Using a recently designed...
The durability of photografted zwitterionic hydrogel coatings on cochlear implant biomaterials was examined to determine the viability these antifouling surfaces during insertion and long-term usage. Tribometry used effect lubricity with varying hydration levels, applied normal force, time frame. Additionally, flexural resistance investigated using mandrel bending. Ex vivo assessed by determining coefficient friction between tissues treated surfaces. Furthermore, implantation force measured...
Abstract Objective Durability of photografted zwitterionic hydrogel coatings on cochlear implant biomaterials was examined to determine viability these antifouling surfaces during insertion and long-term usage. Approach: Tribometry used the effect lubricity with varying hydration level, applied normal force, timeframe. Additionally, flexural resistance investigated using mandrel bending. Ex vivo durability assessed by determining coefficient friction between tissues treated surfaces....
Abstract The foreign body response to implanted materials often complicates the functionality of sensitive biomedical devices. For cochlear implants, this can reduce device performance, battery life and preservation residual acoustic hearing. As a permanent passive solution response, work investigates ultra-low-fouling poly(carboxybetaine methacrylate) (pCBMA) thin film hydrogels that are simultaneously photo-grafted photo-polymerized onto polydimethylsiloxane (PDMS). cellular anti-fouling...