A5024474064- Microbial Natural Products and Biosynthesis
- Synthetic Organic Chemistry Methods
- 14-3-3 protein interactions
- Carbohydrate Chemistry and Synthesis
- Plant-derived Lignans Synthesis and Bioactivity
- Cyclopropane Reaction Mechanisms
- Microbial Metabolism and Applications
- Genomics and Phylogenetic Studies
- Marine Sponges and Natural Products
- Ubiquitin and proteasome pathways
- Chemical synthesis and alkaloids
- Enzyme Catalysis and Immobilization
- Catalytic Alkyne Reactions
- Cancer therapeutics and mechanisms
- Microbial Metabolic Engineering and Bioproduction
- Chemical Synthesis and Reactions
Rice University
2022-2025
The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology
2023
Beijing National Laboratory for Molecular Sciences
2017-2019
Peking University
2017-2019
Center for Life Sciences
2017-2019
Asymmetric total synthesis of structurally intriguing and highly oxygenated lancifodilactone G acetate (7) has been achieved for the first time in 28 steps from a cheap commodity chemical, 2-(triisopropylsiloxy)-1,3-butadiene.
As one of the most potent and selective protein phosphatase inhibitors, fostriecin shows a broad range anticancer activity. In light fostriecin’s antiproliferative properties, phase I clinical trial was conducted on natural product, but soon halted due to issues with compound stability purity. Numerous efforts in past two decades have yielded 17 successful syntheses that proceed 19 34 steps. Herein, we develop modular chemoenzymatic approach provides its analogs collective manner 9 steps...
Abstract Complex natural products are a proven and rich source of disease-modulating drugs efficient tools for the study chemical biology drug discovery. The architectures complex generally considered to represent significant barriers synthesis. Here we describe concise asymmetric synthesis 19-dehydroxyl arisandilactone A—which belongs family architecturally unique, highly oxygenated nortriterpenoids isolated from medicinal plant Schisandra arisanensis . This takes place by means...
Pre-schisanartanin C belongs to the family of Schisandra nortriterpenoids with potent antihepatitis, antitumor, and anti-HIV activities. This paper presents enantioselective total synthesis pre-schisanartanin (1). An important step in 1 is gold-catalyzed intramolecular cyclopropanation a 1,8-enyne substrate bearing secondary ester group at propargylic position prepare bicyclo[6.1.0]nonane core. Additional highlights include (i) an asymmetric Diels–Alder reaction install initial C5...
Actinobacteria, the bacterial phylum most renowned for natural product discovery, has been established as a valuable source drug discovery and biotechnology but is underrepresented within accessible genome strain collections. Herein, we introduce Natural Products Discovery Center (NPDC), featuring 122,449 strains assembled over eight decades, genomes of first 8490 NPDC (7142 Actinobacteria), online Portal making both publicly available. A comparative survey RefSeq Actinobacteria highlights...
The stereoselective construction of the CDEFGH ring system lancifodilactone G is described. key steps in this synthesis are (i) ring-closing metathesis for formation oxa-bridged eight-membered ring; (ii) an intramolecular Pauson–Khand reaction sterically congested F and (iii) sequential cross-metathesis, hydrogenation, lactonization reactions installation anomerically stabilized bis-spiro ketal fragment G.
Fusicoccane diterpenoids display intriguing biological activities, including the ability to act as molecular glue modulators of 14-3-3 protein–protein interaction. However, their innate structural complexity and diverse oxygenation patterns present enormous synthetic challenges. Here, a modular chemoenzymatic approach this natural product family that combines de novo skeletal construction late-stage hybrid C–H oxidations is presented. A convergent fragment coupling strategy allowed rapid...
Cotylenin A and fusicoccin are two flagship members of the fusicoccane diterpenoid family that capable acting as molecular glues to stabilize interaction between 14-3-3 proteins their clients. Herein, we report a concise che-moenzymatic synthesis cotylenol, aglycone cotylenin A. Key features contribute brevity route include union cyclopentene fragments in an allylative coupling, one-pot Prins cyclization-transannular hydride shift sequence, late-stage enzymatic oxidation install key tertiary...