A5065750068- Eosinophilic Esophagitis
- Genetic and phenotypic traits in livestock
- Tracheal and airway disorders
- Genetic Associations and Epidemiology
- Artificial Intelligence in Healthcare
- Eosinophilic Disorders and Syndromes
- Esophageal and GI Pathology
- IL-33, ST2, and ILC Pathways
- Innovations in Medical Education
- Coronary Interventions and Diagnostics
- Healthcare innovation and challenges
- Interprofessional Education and Collaboration
- Hepatitis C virus research
- Folate and B Vitamins Research
- Public Health Policies and Education
- Cognitive Abilities and Testing
- Genetic Mapping and Diversity in Plants and Animals
- Artificial Intelligence in Healthcare and Education
- Biliary and Gastrointestinal Fistulas
- Amoebic Infections and Treatments
- Pleural and Pulmonary Diseases
- Problem and Project Based Learning
- Renal and Vascular Pathologies
- Genetics and Plant Breeding
- Service-Learning and Community Engagement
Xavier University
2014-2024
Cincinnati Children's Hospital Medical Center
2011-2021
University of Cincinnati
1982-2021
London School of Economics and Political Science
2020
Cancer Research And Biostatistics
2014-2016
University of Cincinnati Medical Center
1982-2014
Institute of Human Genetics
2014
Autoimmune Technologies (United States)
2014
Eosinophilic esophagitis (EoE) is diagnosed by symptoms, and at least 15 intraepithelial eosinophils per high power field in an esophageal biopsy. Other pathologic features have not been emphasized. We developed a histology scoring system for biopsies that evaluates eight features: eosinophil density, basal zone hyperplasia, abscesses, surface layering, dilated intercellular spaces (DIS), epithelial alteration, dyskeratotic cells, lamina propria fibrosis. Severity (grade) extent (stage) of...
The COVID-19 pandemic caused a sudden shift to virtual platforms. Physical distance and limited experience with both synchronous asynchronous teamwork at work school hampered problem-solving the development of critical thinking skills. Under these circumstances, implementation team-based problem-based learning (TBL, PBL, respectively) required reevaluation how teams collaborate engage in remotely. research team conducted systematic review identify health services studies, themes, attributes...
CT differentiation of subphrenic abscess and pleural effusionES Alexander, AV Proto RA ClarkAudio Available | Share
Although the technical and analytic complexity of whole genome sequencing is generally appreciated, best practices for data cleaning quality control have not been defined. Family based can be used to guide standardization specific metrics in nonfamily data. Given low mutation rate, Mendelian inheritance errors are likely as a result erroneous genotype calls. Thus, our goal was identify characteristics that determine errors. To accomplish this, we chromosome 3 family from Genetic Analysis...
Esophageal strictures (ES) in children are not well characterized pathologically. We report unique histopathologic analyses of resected acquired ES and control esophagi (CE).Muscle layer thicknesses were measured intact well-oriented areas; inflammatory cells counted the most inflamed high power field (hpf). Sections stained with relevant antibodies. Results expressed as median, lower upper quartiles. Wilcoxon Rank Sums non-parametric test was used to compare groups; P ≤ 0.05 considered...
Family based association studies are employed less often than case-control designs in the search for disease-predisposing genes. The optimal statistical genetic approach complex pedigrees is unclear when evaluating both common and rare variants. We examined empirical power type I error rates of 2 approaches, measured genotype family-based testing, through simulations from a set multigenerational pedigrees. Overall, these results suggest that much larger sample sizes will be required was...
Population substructure is a well-known confounder in population-based case-control genetic studies, but its impact family-based studies unclear. We performed population analysis using extended families of admixed to evaluate power and Type I error an association study framework. Our shows that was improved by 1.5% after principal components adjustment. also reduced 2.2% adjusting for family substratification. The presence underscored discriminant analysis, which over 92% individuals were...
Genetic studies often collect data on multiple traits. Most genetic association analyses, however, consider traits separately and ignore potential correlation among traits, partially because of difficulties in statistical modeling multivariate outcomes. When are measured a pedigree longitudinally, additional challenges arise addition to between trait is correlated with its own measures over time measurements other family members. We developed Bayesian model for analysis bivariate...
Lecture is a frequently employed method of instruction in institutions higher education, despite evidence that this may not be effective achieving student learning (Stains et al., 2018). “Real-world” experiences are needed to bring classroom concepts life and foster interconnectedness enhance students’ interpersonal competence (Remington-Doucette 2013). Community service-learning (CSL) projects achieve these objectives extend opportunities ways cannot accomplished solely within (Bettencort,...