A5024871868- Healthcare Operations and Scheduling Optimization
- Romani and Gypsy Studies
- Adolescent Sexual and Reproductive Health
- HIV/AIDS Research and Interventions
- Chromosomal and Genetic Variations
- Geriatric Care and Nursing Homes
- Plant Disease Resistance and Genetics
- Genetic factors in colorectal cancer
- Forensic and Genetic Research
- Frailty in Older Adults
- Public Health Policies and Education
- Metabolism and Genetic Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Family and Patient Care in Intensive Care Units
- Syphilis Diagnosis and Treatment
- Chromatin Remodeling and Cancer
- Psychology of Moral and Emotional Judgment
- Operations Management Techniques
- Land Rights and Reforms
- Connective tissue disorders research
- Advanced Queuing Theory Analysis
- Telemedicine and Telehealth Implementation
- Genetics and Neurodevelopmental Disorders
- Interprofessional Education and Collaboration
- Medical Coding and Health Information
Cardiff University
1975-2025
University of Rochester Medical Center
2024
University of South Wales
2008-2020
American Nonsmokers' Rights Foundation
2019
Barts Health NHS Trust
2016-2017
Cincinnati Children's Hospital Medical Center
2017
St George's Hospital
2014
Victoria University of Wellington
2014
Vanderbilt University
2010
Purdue University West Lafayette
1998
Engineering of enzymes to more efficiently activate genotoxic prodrugs holds great potential for improving anticancer gene or antibody therapies. We report the development a new, GFP-based, high-throughput screening platform enable engineering prodrug-activating by directed evolution. By fusing an inducible SOS promoter engineered GFP reporter gene, we were able measure levels DNA damage in intact Escherichia coli and separate cell populations fluorescence activating sorting (FACS). In two...
Nonadherence to treatment recommendations is associated with poorer outcomes in inflammatory bowel disease and may increase the cost of care. We examined longitudinal relationship between nonadherence health care costs hypothesized that at least 3 distinct trajectories would be observed increasing account for significantly greater after controlling activity.Ninety-nine patients aged 2 21 years were recruited into this 2-year study. Medication possession ratios calculated from pharmacy refill...
To identify (1) the non-medical healthcare professionals in Wales qualified to prescribe medicines (including job title, employer, where prescribing qualification is used, care setting and service provided); (2) mode of used by these professionals, frequency with which are prescribed different ways used; (3) safety clinical governance systems within practise.National questionnaire survey.All three National Health Service (NHS) Trusts seven Boards (HB) Wales.Non-medical prescribers.379 (63%)...
Eleven US states and Washington, DC, legalized recreational (adult use) cannabis. Seven states—Alaska, California, Colorado, Massachusetts, Nevada, Oregon, Washington—allow cannabis sales. A public health concern is that exemptions in state or local smoke-free laws for smoking vaping will weaken laws, expose the to secondhand cannabis, renormalize smoking. We describe experience of seven challenges faced maintaining laws. Using elements a tobacco control framework, we identify best practices...
70)2 APRIL 21, t934
This paper investigates the planning of virtual ward (VW) capacity including remote monitoring frail and elderly patients. The main objective is to optimize VW hub locations across a region in United Kingdom. Furthermore, assigning optimal number clinicians different regions needs be considered. We develop mathematical model that minimizes setup travel costs hubs staff. Our experimental analysis evaluates levels demand considering postcode areas within Trusts, also known as Health Boards,...
Objectives Chlamydia trachomatis (CT) , Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV) are curable, mostly asymptomatic, STIs that cause adverse maternal perinatal outcomes. Most countries do not test for those infections during antenatal care. We implemented a CT, NG TV testing treatment programme in an clinic Gaborone, Botswana. Methods conducted prospective study the at Princess Marina Hospital offered pregnant women who were 18 years or older less than 35 weeks of gestation,...
Severe Sillence type II/III Osteogenesis imperfecta (OI) is a lethal or severely crippling disease with either autosomal dominant recessively inherited I collagen mutations. Here we describe the detailed clinical features of thin‐ribbed OI variant deformed limbs. The three consecutively affected children showed no genetic linkage two genes, which implies that novel mechanism causes this phenotype. It can be prevented using ultrasound to diagnose foetuses.
Seventy cases of Down syndrome have been ascertained in South Glamorgan during the period 1968 to 1976. This gives an overall incidence 1 658 live births. Analysis data on basis single years maternal age 200 by 36 years, 100 40 and 50 44 years. All figures are for births at delivery.
As the demand for critical care beds rises each year, hospitals must be able to adapt. Delayed transfer of reduces available capacity and increases occupancy. The use mathematic modeling within healthcare systems has ability aid planning resources. Discrete-event simulation models can determine optimal number required simulate different what-if scenarios.Complex discrete-event model was developed using a warm-up period 30 days ran trials against 2-year with mean calculated runs. A variety...
A South Wales gypsy kindred of Romany origin had a high incidence phenylketonuria along with other recessively inherited disorders. There was degree consanguinity (F = 0-017) an excess non-specific mental subnormality among known consanguineous matings. Phenylketonuria and number disorders have been recorded from populations, but it is uncertain whether this results generally gene frequency for the or more local factors.
Data are presented on polymorphic genetic markers of 84 Welsh gypsies, members an inbred population characterised by a high incidence phenylketonuria and other recessively inherited diseases. Sixteen loci were studied: the ABO blood group distribution was comparable to that surrounding population, B gene frequency being 7-5%, lower than most earlier studies in gypsies. The haptoglobin 1 (23-7%) very different from British resembling found India some previously reported gypsy groups. data...
Summary B-chromosomes ranging in number from one to 12 had a deleterious effect on the vigour and fertility of population tetraploid hybrids between : (Natural 4×) Dactylis glomerata ssp. (Induced lusitanica. Similar trends seed set were shown by original diploid D. lusitanica lines, but pollen appeared be enhanced low numbers B-chromosomes. With increasing B-chromosome induced showed reduction total within each cross.
Summary Young people attending genitourinary medicine services are at high risk of unplanned pregnancy. We performed a retrospective cohort study to identify characteristics pregnant teenagers accessing an inner London service. There were 481 pregnancies in 458 with 54 previous and 46 terminations The under-18 under-16 teenage pregnancy rates 92.1 85.8 per 1000 age-matched clinic attendees, respectively. Median age was 17.1 years. ‘Black Other’ (‘Black British’, ‘Mixed White-Black Caribbean’...
The 25th anniversary of the acquired immunodeficiency syndrome (AIDS) in United States occurred 2006. Despite advances detection, treatment, and care, AIDS, along with human virus (HIV), other sexually transmitted diseases (STDs) remain formidable opponents. Tremendous strides have been made educating public about associated risk factors effective prevention methods. However, this has less communities color. paper describes collaboration among health practitioners academics to design conduct...
<h3>Background:</h3> Black or African American women are disproportionately affected by SLE [1, 2]. but remain underrepresented in research studies. The relationships between discrimination, social support and disease outcomes have not been thoroughly investigated with SLE. <h3>Objectives:</h3> goal of this study is to evaluate the relationship racial support, <h3>Methods:</h3> Adult meeting either 1997 ACR revised criteria SLICC for a control group without any connective tissue were...
Summary In diploid and autotetraploid Dactylis glomerata ssp. lusitanica its allo-tetraploid hybrids with D. glomerata, B-chromosomes undergo non-disjunction preferential segregation to the generative nucleus at first pollen mitosis. This results in transmission by male gametes of double number received microspore completion meiosis. mechanism numerical increase is similar that reported for a other species Gramineae. On female side, normal.