A5042868890- Cannabis and Cannabinoid Research
- Neurotransmitter Receptor Influence on Behavior
- Bipolar Disorder and Treatment
- GABA and Rice Research
- Tryptophan and brain disorders
- Free Radicals and Antioxidants
- Neuroscience and Neuropharmacology Research
- Biochemical effects in animals
- Sleep and Wakefulness Research
- Diet, Metabolism, and Disease
- Biochemical Acid Research Studies
- Photochemistry and Electron Transfer Studies
- Child and Adolescent Psychosocial and Emotional Development
Bar-Ilan University
2018-2024
The cannabis plant exerts its pharmaceutical activity primarily by the binding of cannabinoids to two G protein-coupled cannabinoid receptors, CB1 and CB2. role that terpenes play in this activation has been considered debated repeatedly, based on only limited experimental results. In current study we used a controlled in-vitro heterologous expression system quantify receptors sixteen individually, tetrahydrocannabinol (THC) alone THC-terpenes mixtures. results demonstrate all terpenes, when...
The pathophysiology of major depressive disorder (MDD) is diverse and multi-factorial, yet treatment strategies remain limited. While women are twice as likely to develop the men, many animal model studies antidepressant response rely solely on male subjects. endocannabinoid system has been linked depression in clinical pre-clinical studies. Cannabidiolic Acid-Methyl Ester (CBDA-ME, EPM-301) demonstrated anti-depressive-like effects rats. Here, we explored acute CBDA-ME some possible...
Background: The efficacy of cannabis treatment is determined by the active pharmaceutical ingredients (APIs) ingested composition. Despite smoking predominancy in treatment, very little known regarding its yield and provision rate APIs. Material Methods: Ten experiments were performed, studying changes APIs content during smoking, using a designated machine. was evaluated via analysis cigarette's residuals smoke composition; cannabinoid terpene assessed. Results: Results demonstrated...