A5016686238- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Hemodynamic Monitoring and Therapy
- Heart Failure Treatment and Management
- Streptococcal Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Systemic Lupus Erythematosus Research
- Anesthesia and Pain Management
- Infective Endocarditis Diagnosis and Management
- Antibiotic Use and Resistance
- Renal Diseases and Glomerulopathies
- Pharmaceutical studies and practices
- Sepsis Diagnosis and Treatment
- T-cell and B-cell Immunology
- Viral Infections and Immunology Research
Duke University Hospital
2022-2025
Sturdy Memorial Hospital
2023
University of North Carolina at Chapel Hill
2017
Abstract Tissue-specific immune responses play an important role in the pathology of autoimmune diseases. In systemic lupus erythematosus, deposits IgG-immune complexes and activation complement kidney have long been thought to promote inflammation nephritis. However, events that localize cells non-lymphoid tertiary organs sustain tissue-specific remain undefined. this manuscript, we show BAFF promotes leading Using inducible model found passive transfer antinucleosome IgG into AID−/−MRL/lpr...
Blood cultures obtained in the emergency department (ED) may become positive after discharge. Healthcare professionals must determine if these results represent true infection or a likely contaminant. An institutional algorithm was developed to assist with healthcare professional response blood for S. aureus and coagulase-negative staphylococci (CoNS) situations. We conducted single system, multisite cohort study comparing before implementation of an ED decision-making from November 2022...
Outpatient Parenteral Antibiotic Therapy (OPAT) provides coordinated services to deliver parenteral antibiotics outside of the acute care setting. However, reduction in monitoring and supervision may impact risks readmission hospital. While identifying those at greatest risk hospital through use computer decision support systems could aid its prevention, validation such tools this patient population is lacking.The primary aim study determine ability electronic health record-embedded EPIC...
Cardiovascular implantable electronic device (CIED) infections have high mortality and morbidity. CIED secondary to gram-negative pathogens are rare, there few data regarding their treatment. We report a case of 60-year-old male who developed recurrent Salmonella enteritidis bacteremia leading infection nonsusceptibility ciprofloxacin.
Abstract Objectives Outpatient parenteral antimicrobial therapy (OPAT) is associated with high hospital readmission rates. A 30 day unplanned risk prediction model for OPAT patients has been developed in the UK. Given significant differences patient mix and methods of delivery, we explored its utility Duke University Health System (DUHS) receiving OPAT. Methods We analysed episodes adult from two hospitals between 1 July 2019 February 2020. The discriminative ability to predict all-cause...
Abstract Background Patients may be discharged from the emergency department (ED) prior to final data blood cultures. When positive, ED provider must evaluate determine next steps in caring for patient. Up 55% of positive cultures can contaminants, and calling patients back cause undue burden if no treatment or further evaluation is needed. We developed a toolkit assist response Staphylococcus aureus Coagulase-negative staphylococci (CoNS) ED. It identifies which need return (callback) do...
Abstract Background Outpatient parenteral antimicrobial therapy (OPAT) is used for patients that require prolonged durations of intravenous (IV) antimicrobials and who are healthy enough to receive the medications in outpatient setting. While OPAT both efficacious cost-effective, hospital readmission rates high. Durojaiye colleagues UK developed a 30-day unplanned risk prediction model patients. Given differences patient mix methods delivery, we validated established assessment Duke...