A5088926287- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- Global Maternal and Child Health
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- HIV-related health complications and treatments
- Sex work and related issues
- HIV/AIDS drug development and treatment
- Health and Conflict Studies
- Mycobacterium research and diagnosis
- Infectious Diseases and Mycology
- Viral Infections and Outbreaks Research
- Economic and Environmental Valuation
- Suicide and Self-Harm Studies
- Child Nutrition and Water Access
- Infectious Encephalopathies and Encephalitis
- HIV/AIDS Impact and Responses
- Mental Health Treatment and Access
- Migration, Health and Trauma
- Malaria Research and Control
- Alcoholism and Thiamine Deficiency
- Neurological and metabolic disorders
- Reproductive Health and Contraception
- Infectious Diseases and Tuberculosis
Columbia University
2015-2021
Inserm
2019-2020
Université de Bordeaux
2018-2020
Bordeaux Population Health
2019-2020
National Directorate of Geology
2020
ICAP Global Health
2016-2017
AIDS United
2015
Médecins Sans Frontières
2011
Background Concerning gaps in the HIV care continuum compromise individual and population health. We evaluated a combination intervention strategy (CIS) targeting prevalent barriers to timely linkage sustained retention Mozambique. Methods findings In this cluster-randomized trial, 10 primary health facilities city of Maputo Inhambane Province were randomly assigned provide CIS or standard (SOC). The included point-of-care CD4 testing at time diagnosis, accelerated ART initiation, short...
Little is known about immunovirological treatment outcomes and adherence in HIV/AIDS patients on antiretroviral therapy (ART) treated using a simplified management approach rural areas of developing countries, or the main factors influencing those clinical practice. Cross-sectional immunovirological, pharmacological, were evaluated all alive fixed-dose ART combinations for 24 months, random sample 12 months. Risk virological failure (>1,000 copies/ml) subtherapeutic (ARV) concentrations...
Prevention of mother-to-child transmission (PMTCT) is essential in HIV/AIDS control. We analysed 2000-05 data from mother-infant pairs our PMTCT programme rural Uganda, examining utilization and outcomes, HIV rates predictors death or loss to follow-up (LFU). Out 19 017 women, 1 037 (5.5%) attending antenatal care services tested positive. Of these, 517 (50%) enrolled the gave birth 567 infants. Before tracing, 303 (53%) mother–infant were LFU. Reasons for dropout infant lack understanding...
Introduction Option B+, an approach that involves provision of antiretroviral therapy (ART) to all HIV-infected pregnant women for life, is the preferred strategy prevention mother child transmission HIV. Lifelong retention in care essential its success. We conducted a discrete choice experiment Ethiopia and Mozambique identify health system characteristics by promote continuity care. Methods Women living with HIV receiving at hospitals Oromia Region, Zambézia Province, were shown nine cards...
Among people living with HIV/AIDS, nutritional support is increasingly recognized as a critical part of the essential package care, especially for patients in sub-Saharan Africa. The objectives study were to evaluate outcomes HIV-positive malnourished adults treated ready-to-use therapeutic food and identify factors associated nutrition programme failure.We present results from retrospective cohort analysis aged 15 years or older body mass index less than 17 kg/m² enrolled three HIV/AIDS...
Despite the extraordinary scale up of HIV prevention, care and treatment services in sub-Saharan Africa (SSA) over past decade, overall effectiveness programs has been significantly hindered by high levels attrition across continuum. Data from "real-life" settings are needed on an easy to deliver package that can improve performance continuum.We conducting implementation science study using a two-arm cluster site-randomized design determine combination intervention strategy (CIS) feasible,...
Background A beriberi outbreak occurred in the Maison d'Arrêt et de Correction d'Abidjan (MACA), a detention center Abidjan, Côte d'Ivoire, between October 2002 and April 2003. Objective retrospective investigation was conducted to document Methods descriptive analysis case–control study were performed. probable case patient defined as person detained 2003 with at least two of following symptoms: bilateral leg edema, dyspnea, positive squat test, motor deficiencies, paresthesia. definite who...
Abstract Death rates exceeded emergency thresholds at 4 sites during epidemics of Plasmodium falciparum malaria in Burundi (2000–2001) and Ethiopia (2003–2004). Deaths likely from ranged 1,000 to 8,900, depending on site, accounted for 52% 78% total deaths. Earlier detection better case management are needed.
Abstract The ongoing conflict in Ituri, Democratic Republic of Congo (DRC), has led to more than 50,000 deaths, 500,000 displaced civilians and continuing, unacceptably high, mortality since 1999. In February 2005, after a resurgence violence further displacements, Médecins Sans Frontières (MSF) launched an emergency response three internally persons (IDP) camps Ituri. We performed rapid health assessment April 2005 one the IDP evaluate (due or disease) camp living conditions. retrospective...
Children living with HIV continue to be in urgent need of combined antiretroviral therapy (ART). Strategies scale up and improve pediatric care resource-poor regions, especially sub-Saharan Africa, require further research from these settings. We describe treatment outcomes children treated rural Uganda after 1 2 years ART start.Cross-sectional assessment all for 12 (M12) 24 (M24) months was performed. CD4 counts, RNA levels, resistance patterns, non-nucleoside reverse transcriptase...
Challenges to ensuring timely linkage and retention in HIV care are well documented. Combination intervention strategies can be effective improving the continuum. Data on feasibility acceptability of types within packages limited.The Engage4Health study assessed effectiveness a combination strategy increase among adults newly diagnosed with Mozambique. The included 2 health communication interventions-modified delivery pre-antiretroviral therapy (pre-ART) counseling sessions SMS...
Migrant miners from Mozambique who work in South Africa and their partners are at substantial risk for HIV infection. We conducted a cross-sectional study to assess the willingness of migrant female take short-term pre-exposure prophylaxis (PrEP) prevention acquisition. The was Gaza Province, Mozambique, between September October 2015. A total 131 male completed questionnaire. Subsequently, 48 in-depth interviews among 3 focus-group discussions (6 participants each) were conducted....
To evaluate the effectiveness of prevention mother-to-child transmission (PMTCT) Option B+ programme in two provinces with high human immunodeficiency virus (HIV) burden Mozambique over first four years implementation.We assessed PMTCT cascade antenatal care (ANC) from July 2013 to December 2017 using facility-level data and performed a retrospective cohort analysis patient-level data. We compared 12-month antiretroviral therapy (ART) retention rates between women HIV infection who initiated...
A case-control study was carried out in 3 highly endemic regions of Cote d’Ivoire to risk factors for Buruli ulcer. case defined as a ulcer occurring less than one year before the date survey, resident investigated and there no history illness. Controls were selected from general population by two stage cluster sampling method. total 116 cases controls included. For cases, male/female sex ratio 0.84, median age 19.5 years 40.5% children 15 years. Biological results obtained 86 (74%) using...
Abstract Background Early diagnosis of human immunodeficiency virus (HIV) is a prerequisite to maximizing individual and societal benefits antiretroviral therapy. Methods Adults ≥18 years age testing HIV positive at 10 health facilities in Mozambique Swaziland received point-of-care CD4+ cell count immediately after diagnosis. We examined median diagnosis, the proportion diagnosed with advanced disease (CD4+ ≤350 cells/μL) severe immunosuppression ≤100 cells/μL), determinants latter 2...
Preexposure prophylaxis (PrEP) offers protection from HIV acquisition if taken as prescribed. We evaluated the feasibility, acceptability, and adherence with short-term PrEP among female sexual partners of migrant miners in Mozambique.HIV-negative were offered daily tenofovir/emtricitabine (TDF/FTC) for 6 weeks concurrent miners' return home. Study visits occurred at baseline, week 4, 6, 8. Dried blood spots (DBSs) collected 4 6.Seventy-four women (median age: 42 years) enrolled, 95%...
The centrality of quality as a strategy to achieve impact within the U.S. President's Emergency Plan for AIDS Relief (PEPFAR) has been widely recognized. However, monitoring program remains challenge many HIV programs, particularly those in resource-limited settings, where human resource constraints and weaker health systems can pose formidable barriers data collection interpretation. We describe practicalities at scale very large multicountry PEPFAR-funded program, based largely facilities....
Effective interventions tailored to specific types of behaviors and contexts are needed for women at risk HIV acquisition. Oral pre-exposure prophylaxis (PrEP) is an efficacious prevention intervention that uses antiretroviral drugs reduce the acquiring infection. In Mozambique, remains a major public health concern, with national prevalence 13%. Studies have demonstrated migration male miners between southern provinces Mozambique South Africa contributing epidemic in Mozambique. This...
HIV disclosure benefits people living with HIV, their partners, and programs. However, data on the prevalence of associated correlates have come largely from patients already in care, potentially overestimating rates precluding examination impact care outcomes.We used an implementation study conducted Maputo City Inhambane Province, Mozambique. Adults were enrolled at testing clinics after diagnosis traced community 1 12 months later when they reported other examined patterns participants'...
Gender inequality has been associated with HIV infection among women. Less is known about the relationship between gender and care continuum outcomes. This study assessed whether household decision-making power (DMP), one component of inequality, was linkage to care, antiretroviral therapy (ART) initiation, or retention in women living Mozambique. The sample included 600 ≥18 years age newly diagnosed Data were collected April 2013 June 2016. DMP three questions participation decisions...
Global targets aim to increase the number of people living with HIV (PLWH) who know their status. Using data from Mozambican facility-based testing and counseling (HTC) a population-based survey, we compared characteristics PLWH diagnosed in HTC general population identify subgroups that are missing health system may be undiagnosed. Male female aged 50+ (PPR = 0.47, p .0001) higher knowledge 0.52, .004) were underrepresented HTC. A proportion patients facilities 25-39 1.23, .02). Female...
Abstract Background : Failure to retain HIV-positive pregnant women on antiretroviral therapy (ART) leads increased mortality for the mother and her child. This study evaluated different retention measures women’s engagement along continuum of care prevention mother-to-child transmission (PMTCT) option B+ services in Mozambique. Methods We compared ‘point’ (patient’s presence 12-month post-ART initiation or any time thereafter) with following definitions: alive 12 month (Ministry Health;...