A5034572150- Ecology and Vegetation Dynamics Studies
- Genetic and phenotypic traits in livestock
- Glycosylation and Glycoproteins Research
- Genetic Neurodegenerative Diseases
- Evolution and Genetic Dynamics
- Mitochondrial Function and Pathology
- Machine Learning in Bioinformatics
- Plant Water Relations and Carbon Dynamics
- RNA and protein synthesis mechanisms
- Genetic diversity and population structure
- Genomics and Phylogenetic Studies
- Plant and animal studies
Temple University
2021-2024
Evolutionary Genomics (United States)
2024
Augustana University
2024
Rad And Gem-Like GTP-Binding Protein 2 (Rem2), a member of the RGK family Ras-like GTPases, is implicated in Huntington’s disease and Long QT Syndrome highly expressed brain endocrine cells. We examine evolutionary history Rem2 identified various mammalian species, focusing on role purifying selection coevolution shaping its sequence protein structural constraints. Our analysis sequences across 175 species found evidence for strong 70% non-invariant codon sites which characteristic essential...
Errors in multiple sequence alignments (MSAs) are known to bias many comparative evolutionary methods. In the context of natural selection analyses, specifically codon models, excessive rates false positives result. A characteristic signature error-driven findings is unrealistically high estimates dN/dS (e.g., >100), affecting only a small fraction ∼0.1%) alignment. Despite widespread use models assess alignment quality, their potential for error correction remains unexplored. We present...
Understanding factors that determine a species' geographical range is crucial for predicting climate-induced shifts. Two milkweed species, Asclepias syriaca and speciosa, have overlapping ranges along moisture gradient in North America are primary food sources endangered monarch caterpillars. With decreasing moisture, long-lived species often exhibit slower growth greater drought tolerance, while many annual faster strategies. Using this fast-slow framework, we assessed whether traits of...