A5068926092- Nanopore and Nanochannel Transport Studies
- Neurotransmitter Receptor Influence on Behavior
- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Drug Transport and Resistance Mechanisms
- Erythrocyte Function and Pathophysiology
- Protein Structure and Dynamics
- DNA and Nucleic Acid Chemistry
- Mass Spectrometry Techniques and Applications
- Chemical synthesis and alkaloids
- Cannabis and Cannabinoid Research
- Pharmacological Receptor Mechanisms and Effects
- Diatoms and Algae Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chemical Reactions and Isotopes
- Cellular transport and secretion
- Calcium signaling and nucleotide metabolism
- Neurobiology and Insect Physiology Research
- Ionic liquids properties and applications
- Advanced biosensing and bioanalysis techniques
- Radical Photochemical Reactions
- Neuropeptides and Animal Physiology
- Membrane-based Ion Separation Techniques
- Retinal Development and Disorders
Columbia University
2024
Icahn School of Medicine at Mount Sinai
2020-2024
New York Proton Center
2023
University of Wisconsin–Madison
2016
Abstract The human trace amine-associated receptor 1 (hTAAR1, hTA1) is a key regulator of monoaminergic neurotransmission and the actions psychostimulants. Despite preclinical research demonstrating its tractability as drug target, molecular mechanisms activation remain unclear. Moreover, poorly understood pharmacological differences between rodent TA1 complicate translation findings from disease models into novel pharmacotherapies. To elucidate hTA1’s on scale investigate underpinnings...
The strength of synaptic connections varies significantly and is a key determinant communication within neural circuits. Mechanistic insight into presynaptic factors that establish modulate neurotransmitter release properties crucial to understanding synapse strength, circuit function, plasticity. We previously identified Drosophila Piccolo-RIM-related Fife, which regulates neurotransmission motor behavior through an unknown mechanism. Here, we demonstrate Fife localizes interacts with RIM...
Abstract Anion Exchanger 1 (AE1, SLC4A1) is the primary bicarbonate (HCO 3 - ) transporter expressed in erythrocyte membranes where it mediates transport of CO 2 between lungs and other tissues via import/export bicarbonate. It also a key regulator structure antigenic recognition. Previous biochemical studies, low-resolution crystal transmembrane domain have provided initial insight into AE1 function. However, questions remain regarding substrate binding as well mechanism inhibition. The...
Serotonin [5-hydroxytryptamine (5-HT)] acts via 13 different receptors in humans. Of these receptor subtypes, all but 5-HT 1e R have confirmed roles native tissue and are validated drug targets. Despite R’s therapeutic potential plausible druggability, the mechanisms of its activation remain elusive. To illuminate pharmacology relation to highly homologous 1F R, we screened a library aminergic ligands at both observe R/5-HT agonism by multicyclic drugs described as pan-antagonists receptors....
ADVERTISEMENT RETURN TO ISSUEPREVViewpointNEXTA Novel Cryo-EM Structure Enables Development of Selective Cannabinoid Receptor DrugsGregory ZilbergGregory ZilbergDepartment Neuroscience, Icahn School Medicine at Mount Sinai, New York, York 10029, United StatesMore by Gregory Zilberg and Daniel Wacker*Daniel WackerDepartment Pharmacological Sciences States*Email: [email protected]More Wackerhttp://orcid.org/0000-0003-4951-7230Cite this: Biochemistry 2020, 59, 17, 1643–1644Publication Date...
Abstract Serotonin (5-hydroxytryptamine, 5-HT) acts via 13 different receptors in humans. Of these receptor subtypes, all but 5-HT 1e R have confirmed roles native tissue and are validated drug targets. Despite R’s therapeutic potential plausible druggability, the mechanisms of its activation remain elusive. To illuminate pharmacology relation to highly homologous 1F R, we screened a library aminergic ligands at both observe 1e/1F agonism by multicyclic drugs described as pan-antagonists...
The human trace amine-associated receptor 1 (hTAAR1, hTA1) is a key regulator of monoaminergic neurotransmission and the actions psychostimulants. Despite preclinical research demonstrating its tractability as drug target, molecular mechanisms activation remain unclear. Moreover, poorly understood pharmacological differences between rodent TA1 complicate translation findings from disease models into novel pharmacotherapies. To elucidate hTA1's on scale investigate underpinnings divergent...