A5033420794- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Pancreatic function and diabetes
- Endoplasmic Reticulum Stress and Disease
- Adipose Tissue and Metabolism
- Cardiac Ischemia and Reperfusion
- Natural Antidiabetic Agents Studies
- Diet, Metabolism, and Disease
- Ubiquitin and proteasome pathways
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Heart Failure Treatment and Management
- Pharmacology and Obesity Treatment
- Diabetes and associated disorders
- Diabetes Management and Research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Blood Pressure and Hypertension Studies
- Polyamine Metabolism and Applications
- Genomic variations and chromosomal abnormalities
- ATP Synthase and ATPases Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Pharmacological Effects and Assays
- Metabolism and Genetic Disorders
University of Utah
2020-2024
University of Tennessee Health Science Center
2023
University of South Dakota
2018-2022
Saroj Gupta Cancer Centre & Research Institute
2007-2019
University of California, Davis
2014-2016
Sinha Institute of Medical Science & Technology
2010-2014
Chaperone-mediated autophagy (CMA) is a chaperone-dependent process of selective cytosolic protein turnover that targets specific proteins to lysosomes for degradation. Enhancing degradation mechanisms has been shown be beneficial in multiple models cardiac disease, including myocardial infarction (MI) and ischemia-reperfusion (I/R) injury. However, the causal role CMA cardiomyocyte injury death largely unknown. Hypoxia an important contributor both MI I/R damage, which are major, precedent...
Abstract Protein quality control mechanisms decline during the process of cardiac aging. This enables accumulation protein aggregates and damaged organelles that contribute to age‐associated dysfunction. Macroautophagy is by which post‐mitotic cells such as cardiomyocytes clear defective proteins organelles. We hypothesized late‐in‐life exercise training improves autophagy, aggregate clearance, function otherwise dysregulated in hearts from old vs. adult mice. As expected, 24‐month‐old male...
Abstract Aims Heart failure due to ischaemic heart disease (IHD) is a leading cause of mortality worldwide. A major contributing factor IHD-induced cardiac damage hypoxia. Sequestosome 1 (p62) multi-functional adaptor protein with pleiotropic roles in autophagy, proteostasis, inflammation, and cancer. Despite abundant expression cardiomyocytes, the role p62 physiology not well understood. We hypothesized that cardiomyocyte-specific deletion evokes hypoxia-induced pathology by impairing...
BACKGROUND: PRDM16 plays a role in myocardial development through TGF-β (transforming growth factor-beta) signaling. Recent evidence suggests that loss of expression is associated with cardiomyopathy mice, although its human unclear. This study aims to determine the impact loss-of-function variants on humans. METHODS: Individuals were identified and consented. Induced pluripotent stem cell–derived cardiomyocytes generated from proband hosting Q187X nonsense variant as an vitro model...
Hypertension and diabetes mellitus are considered to be two major atherosclerotic risk factors for coronary artery disease (CAD). A stress-induced protein identified dermcidin isoform 2 of Mr. 11 kDa from blood plasma hypertensive persons when injected (0.1 μM) in rabbits increased the systolic pressure by 77% diastolic 45% over controls within h. Ingestion acetyl salicylic acid (150 mg/70 kg) these subjects reduced (130 mm Hg) pressures (80 with reduction level normal ranges (9 nM). The was...
Maspin, a 42 kDa protein produced in normal breast cells, has been shown to inhibit the invasion and metastasis of cancer an animal model. Ingestion acetylsalicylic acid (aspirin) by patients reported restore systemic synthesis maspin through stimulation nitric oxide production. Studies were carried out determine effect aspirin on incidence metastasis, which is occur 50% who have previously received chemotherapy, radiation, and/or surgery. Thirty‐five female (aged 41–65 years) with had these...
Excessive aggregation of platelets at the site plaque rupture on coronary artery led to formation thrombus which is reported precipitate acute myocardial infarction (AMI). Nitric oxide (NO) has been inhibit platelet and induce thrombolysis through in situ plasmin. As plasma NO level AMI patients from two different ethnic groups was reduced 0 µM (median) compared 4.0 normal controls, effect restoration ranges rate death due determined.The achieved by a sticking small cotton pad (10×25 mm)...
Abstract The hepatocytes from the adult mice when stimulated by glucose had been reported to synthesize and secrete insulin. feasibility of controlling hyperglycemia in alloxan induced diabetic through hepatic synthesis insulin was studied. Insulin determined vitro translation mRNA immunohistochemistry assayed enzyme linked immunosorbent assay (ELISA). Dermcidin isoform 2 (dermcidin) measured ELISA. Nitric oxide methemoglobin method. quantitated immunoblot technique expression proinsulin...
The effect of dermcidin isoform 2 (dermcidin), an environmentally induced stress protein, was investigated on the genesis diabetes mellitus and hypertension, two major atherosclerotic risk factors. role as factor related to impaired systemic insulin level investigated. Dermcidin prepared by electrophoresis using plasma from subjects with acute ischemic heart disease. Injection 0.2 <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
More than 90% of all hypertensive persons are reported to have essential hypertension (EH), a particular form elevated blood pressure, for which no diagnostic test is currently available. The level plasma renal (R) cortexin (PRC), hypotensive protein produced in the kidney cortex cells, was be reduced from 218 nM normotensive (NP) 0 patients with EH. feasibility using determination PRC by enzyme-linked immunosorbent assay (ELISA) as EH investigated.The determined ELISA electrophoretically...
High altitude illness (HAI) is a cluster of syndromes which develops due to the injury central nervous system produced by reduction partial pressure O2 in atmosphere disappears on decent. The HAI also results prothrombotic condition leading acute coronary syndrome (ACS), cannot be controlled descent ground level. There no diagnosis forewarn impending ACS. A protein identified dermcidin isoform 2 (dermcidin), environmental stresses, has been reported potent diabetogenic agent. Investigation...
Women, before menopause, are known to be resistant the development of acute ischemic heart disease (AIHD). As inhibition platelet aggregation is reported prevent incidences AIHD, effects estradiol and estriol on ADP-induced in platelet-rich plasma were determined. It was found that it not estradiol, most potent estrogenic hormone, but estriol, less than had a minimum inhibitory concentration (MIC) 0.6 nmol/l for 100% aggregation. In contrast, MIC 2.0 (P<0.005, n=40). The stimulation nitric...
The role of stress induced development Type-1 diabetes mellitus (T1DM) as opposed to autoimmunity remains obscure. It has been reported that a protein, identified be dermcidin isoform 2 (dermcidin) inhibited insulin synthesis in both the pancreatic β cells and hepatic cells. As effect could neutralized by increased production systemic nitric oxide (NO), investigations were carried out determine feasibility controlling T1DM through neutralization increase NO. To plasma level subjects (n=45),...
Currently, there is no specific medication for essential hypertension (EH), a major form of the condition, in man. As acetyl salicylic acid (aspirin) reported to stimulate synthesis renal (r)-cortexin, an anti-essential hypertensive protein, and, as aspirin inhibit dermcidin isoform 2 (dermcidin), causative protein EH, role control EH man was studied. Oral administration 150 mg aspirin/70 kg body weight subjects with found reduce both elevated systolic and diastolic blood pressures normal...
It is currently believed that insulin, an essential hormone for carbohydrate metabolism, produced only in the pancreas. Many investigators on other hand had reported various cells different organs of body beside pancreas are also capable synthesizing insulin. This not has a critical role but protein to prevent atherosclerosis and hypertension. The multifunctional synthesis presented review. Insulin was be synthesized liver, brain, thymus, adipocytes, gastrointestinal tract, bone marrow...