A5090108208- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Nerve injury and regeneration
- Automotive and Human Injury Biomechanics
- Axon Guidance and Neuronal Signaling
- Neurogenesis and neuroplasticity mechanisms
- Cardiac Arrest and Resuscitation
- Neuroscience and Neural Engineering
- Electrospun Nanofibers in Biomedical Applications
- Traumatic Ocular and Foreign Body Injuries
- Cellular Mechanics and Interactions
- Tendon Structure and Treatment
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Bone Tissue Engineering Materials
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Muscle activation and electromyography studies
- Optical Coherence Tomography Applications
- Photoacoustic and Ultrasonic Imaging
- Pluripotent Stem Cells Research
- Connexins and lens biology
- EEG and Brain-Computer Interfaces
- Disaster Response and Management
- Spectroscopy Techniques in Biomedical and Chemical Research
New Jersey Institute of Technology
2014-2024
Rutgers, The State University of New Jersey
2023
Hospital of the University of Pennsylvania
2007-2008
Pennsylvania Hospital
2008
University of Pennsylvania
2003-2008
University of Rochester Medical Center
2007
Philadelphia University
2004
Johns Hopkins University
1999-2003
Johns Hopkins Medicine
2003
Large animals can undergo enormous growth during development, suggesting that axons in nerves and white matter tracts rapidly expand as well. Because integrated have no cones to extend from, it has been postulated mechanical forces may stimulate axon elongation matching the of animal. However, this distinct form rapid sustained never demonstrated. Here, we used a microstepper motor system evaluate effects escalating rates stretch on over days weeks culture. We found could be grown at 8 mm/d...
Neural-electrical interface platforms are being developed to extracellularly monitor neuronal population activity. Polyaniline-based electrically conducting polymer fibers attractive substrates for sustained functional interfaces with neurons due their flexibility, tailored geometry and controlled electro-conductive properties. In this study, we addressed the neurobiological considerations of utilizing small diameter (<400 µm) consisting a blend conductive polyaniline polypropylene (PA–PP)...
Elongation of nerve fibers intuitively occurs throughout mammalian development, and is synchronized with expansion the growing body. While most tissue systems enlarge through mitosis differentiation, elongation remarkably unique. The emerging paradigm suggests that axons undergo stretch as contiguous tissues between proximal distal segments spanning fibers. distinct from growth, tension a known stimulus which regulates growth axons. Here, we hypothesized axon stretch-growth process may be...
We developed a miniature quantitative optical coherence elastography (qOCE) instrument with an integrated Fabry-Perot force sensor, for in situ elasticity measurement of biological tissue. The technique has great potential biomechanics modeling and clinical diagnosis. designed the fiber-optic qOCE probe that was used to exert compressive deform tissue at tip probe. Using space-division multiplexed tomography (OCT) signal detected by spectral domain OCT engine, we were able quantify...
Blast-induced traumatic brain injury (bTBI) has been identified as an increasingly prevalent cause of morbidity and mortality in both military civilian populations over the past few decades. Functional outcomes following bTBI vary widely among individuals, chronic neurodegenerative effects including cognitive impairments can develop without effective diagnosis treatment. Genetic predispositions sex differences may affect gene expression changes response to influence individual's probability...
Little is known about extensive nervous system growth after axons reach their targets. Indeed, postnatal animals continue to grow, suggesting that are stretched accommodate the expanding body. We have previously shown can sustain stretch‐growth rates reaching 1 cm/day; however, it remained unknown whether ability transmit active signals was maintained. Here, did not alter sodium channel activation, inactivation, and recovery or potassium activation. In addition, neurons generated normal...
Although peripheral nerve injury is a common consequence of trauma or surgery, there are insufficient means for repair. In particular, critical need improved methods to facilitate regeneration axons across major lesions. Here, we engineered transplantable living nervous tissue constructs provide labeled pathway guide host axonal regeneration. These consisted stretch-grown, longitudinally aligned tracts inserted into poly(glycolic acid) tubes. The (allogenic) were transplanted bridge an...
While most approaches to repair spinal cord injury (SCI) rely on promoting axon outgrowth, the extensive distance that axons would have grow bridge SCI lesions remains an enormous challenge. In this study, we used a new tissue-engineering technique create long nervous tissue constructs spanned by living tracts lesions. Exploiting newfound process of extreme stretch growth, integrated from dorsal root ganglia (DRG) neurons were mechanically elongated in vitro 10 mm over 7 days and encased...
Strategies for nervous system repair arise from knowledge of growth mechanisms via a cone. The distinctive process axon stretch is robust, long-term that may reveal new pathways to accelerate nerve repair. Here, live imaging bioreactor was engineered closely explore cellular events initiated by applied tension. potential between adult and embryonic dorsal root ganglion (DRG) neurons investigated, an important difference in Embryonic axons were capable unidirectional rates 4 mm/d reliably...
Fibrous scaffolds engineered to direct the growth of tissues can be important in forming architecturally functional tissue such as aligning regenerating nerves with their target. Collagen is a commonly used substrate for neuronal applications form surface coatings and hydrogels. The wet spinning technique create collagen fibers without use organic solvents typically accomplished by extruding dispersion into coagulation bath. To well-controlled uniform fibers, we developed an automatic device...
Acoustic startle response (ASR) is a defensive reflex that largely ignored unless greatly exaggerated. ASR suppressed after moderate and severe traumatic brain injury (TBI), but the effect of mild TBI (mTBI) on has not been investigated. Because neural circuitry for resides in pons all mammals, may be good measure brainstem function mTBI. The present study assessed Sprague-Dawley rats mTBI using lateral fluid percussion compared these effects to those spatial working memory. caused profound,...
Abstract Myelin loss in the brain is a common occurrence traumatic injury (TBI) that results from impact‐induced acceleration forces to head. Fast and abrupt head motions, either resulting violent blows and/or jolts, cause rapid stretching of tissue, long axons within white matter tracts are especially vulnerable such mechanical strain. Recent studies have shown mechanotransduction plays an important role regulating oligodendrocyte progenitors cell differentiation into oligodendrocytes....