A5072570067- Chronic Lymphocytic Leukemia Research
- Transplantation: Methods and Outcomes
- PI3K/AKT/mTOR signaling in cancer
- Cytokine Signaling Pathways and Interactions
- RNA Interference and Gene Delivery
- DNA Repair Mechanisms
- Platelet Disorders and Treatments
- Cellular transport and secretion
- Neonatal Health and Biochemistry
- Chronic Myeloid Leukemia Treatments
- Genomics and Chromatin Dynamics
- Omental and Epiploic Conditions
- Biomedical Research and Pathophysiology
- Aldose Reductase and Taurine
- Renal Transplantation Outcomes and Treatments
- Potassium and Related Disorders
- Paraoxonase enzyme and polymorphisms
- Neurogenesis and neuroplasticity mechanisms
- Bacterial biofilms and quorum sensing
- Protein Kinase Regulation and GTPase Signaling
- Cholesterol and Lipid Metabolism
- Adenosine and Purinergic Signaling
- Carbohydrate Chemistry and Synthesis
- Lysosomal Storage Disorders Research
- Pneumocystis jirovecii pneumonia detection and treatment
SUNY Upstate Medical University
2016-2024
State University of New York
2016-2023
Toronto General Hospital
2021
Toronto General Hospital Research Institute
2021
University Health Network
2020
Upstate University Hospital
2020
Center for Rheumatology
2019
Loyola University Medical Center
2016
Christ Hospital
2016
Edward Hines, Jr. VA Hospital
2016
Characterizing the functional overlap and mutagenic potential of different pathways chromosomal double-strand break (DSB) repair is important to understand how mutations arise during cancer development treatment. To this end, we have compared role individual factors in three mammalian DSB repair: alternative-nonhomologous end joining (alt-NHEJ), single-strand annealing (SSA), homology directed (HDR/GC). Considering early steps repair, found that end-processing KU CtIP affect all similarly,...
Abstract Activation of the mechanistic target rapamycin (mTOR) is a key metabolic checkpoint pro-inflammatory T-cell development that contributes to pathogenesis autoimmune diseases, such as systemic lupus erythematosus (SLE), however, underlying mechanisms remain poorly understood. Here, we identify functional role for Rab4A-directed endosome traffic in CD98 receptor recycling, mTOR activation, and accumulation mitochondria connect pathways with immune cell lineage pathogenesis. Based on...
Although several reports have documented nitric oxide (NO) regulation of biofilm formation, the molecular basis this phenomenon is unknown. In many bacteria, an H-NOX (heme-nitric oxide/oxygen-binding) gene found near a diguanylate cyclase (DGC) gene. domains are conserved hemoproteins that known NO sensors. It widely recognized cyclic di-GMP (c-di-GMP) ubiquitous bacterial signaling molecule regulates transition between motility and biofilm. Therefore, may influence formation through DGC,...
The omentum is a sheet-like tissue attached to the greater curvature of stomach and contains secondary lymphoid organs called milky spots. has been used for its healing potential over 100 years by transposing omental pedicle injured (omental transposition), but mechanism which helps process damaged tissues not well understood. Omental transposition promotes expansion pancreatic islets, hepatocytes, embryonic kidney, neurons. cells (OCs) can be activated foreign bodies in vivo. Once...
Recent investigations in humans and mouse models with lupus have revealed evidence of mitochondrial dysfunction production reactive oxygen species (mROS) T cells neutrophils. This can provoke numerous cellular changes including oxidation nucleic acids, proteins, lipids even induction cell death. We previously observed that from patients lupus, the increased mROS is capable provoking oligomerisation antiviral stimulator (MAVS) type I interferon (IFN-I). SLE neutrophils also promotes formation...
The heterogeneity in disease pathology, the unpredictability prognosis, and variability response to therapy make mantle cell lymphoma (MCL) a focus of novel therapeutic development. MCL is characterized by dysregulated expression cyclin D1 through chromosome t(11;14) translocation. international prognostic index (MIPI), ki-67 proliferation index, TP53 mutation status are currently utilized for prognostication. With advances pharmacokinetic analysis drug discovery, treatment strategy has...
Abstract Cellular reprogramming or conversion is a promising strategy to generate desired stem cell types from somatic cells. Neural cells (NSCs) have the potential regenerate central nervous system tissue and repair damage in response injury. However, NSCs are difficult isolate human tissues expand sufficient quantities for therapy. Here, we report method neural cord blood CD34-positive by ectopic expression of OCT4 feeder-free system. The induced (iNSCs) show characteristic NSC-like...
Overexpression and long terminal repeat (LTR) polymorphism of the HRES‑1/Rab4 human endogenous retrovirus locus have been associated with T cell activation disease manifestations in systemic lupus erythematosus (SLE). Although genomic DNA methylation is diminished overall SLE, its role HRES-1/Rab4 expression unknown. Therefore, we determined how lupus-associated polymorphic rs451401 alleles LTR regulate transcription from promoter thus affect activation. The results showed that cytosine–119...
Megakaryocytic cell maturation involves polyploidization, and megakaryocyte (MK) ploidy correlates with their platelet production. Retardation of MK is closely associated poor engraftment after cord blood transplantation neonatal thrombocytopenia. Despite the high prevalence thrombocytopenia in a range setting that affect infants to adults, there are still very limited modalities treatment. Human CD34+ cells were isolated from or bone marrow samples acquired consenting patients. Cells...
A 67-year-old female patient presented asymptomatically for further evaluation of a chest mass. Other than significant smoking history, the had been healthy with recently treated case uncomplicated pneumonia. The mass originated in aortopulmonary window left mediastinum and invaded proximally into superior pulmonary vein subsequently atrium. protrusion mitral valve occupied 50% atrium space but showed no clinical symptoms valvular blockade. Poorly differentiated squamous cell carcinoma was...
Abstract Introduction Expression of Rab4A is increased in T cells patients and mice with SLE. Overexpression forms a positive feedback loop mTOR that can be blocked therapeutic efficacy To determine the impact this gene on disease development, triple-congenic lupus-prone Sle1.2.3 mouse strain (TC) have been backcrossed C57Bl/6 wild-type (WT) carry floxed Rab4AQ72L (TC-FL) alleles or lack (TC-KO). Methods Proteinuria was assessed by Bradford assay. Splenocytes were examined flow cytometry....
Purpose: To study the efficacy and side effects of converting to Belatacept-Based (Bela) therapy in recipients kidney transplant (KT). Methods: we studied patient transplanted between 5/2011 8/2019. 39 patients were converted Bela-Based therapy. Of these only 16 completed 2 years observation included this study. Patients stratified by two groups. Group 1, Bela + Tac prednisone (n=5), 2, MMF (n=11). All donor, recipient demographic factors examined. We compared groups regard rejection rates,...