A5017614954- Cholinesterase and Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Inflammatory mediators and NSAID effects
- Reproductive System and Pregnancy
- Tryptophan and brain disorders
- Aldose Reductase and Taurine
- Biochemical effects in animals
- Bone Metabolism and Diseases
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
National Institute of Immunology
2023-2024
Aging is associated with changes in circulating levels of various molecules, some which remain undefined. We find that concentrations taurine decline aging mice, monkeys, and humans. A reversal this through supplementation increased the health span (the period healthy living) life mice monkeys. Mechanistically, reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, attenuated inflammaging. In humans, lower correlated...
Recent discoveries have established the pivotal role of IL-9-secreting immune cells in a wide spectrum inflammatory and autoimmune diseases. However, little is known about how IL-9 contributes to etiology bone loss PMO. We observed that has pathological impact on ovariectomized (Ovx) mice. Our vivo temporal kinetics analysis revealed estrogen deprivation enhanced production from Th (majorly Th9 Th17). Both our ex studies corroborated these findings Ovx mice, as diminishes potential produce...
Abstract Molecular near-infrared (NIR) imaging is an emerging pre-clinical tool for labeling Alzheimer's disease (AD) pathogenic biomarkers, especially cerebral amyloid-beta (Aβ) plaques. Herein, we present a series of acceptor-π-donor based molecular NIR probes, composed rhodanine (acceptor fragment) in conjugation with coumarin or carbostyril (donor nucleus. The most promising probe 19 has desirable binding affinity ( K d = 0.143 μM) against Aβ aggregates little no nonspecific interaction...