John C. Kennedy

ORCID: 0000-0002-6672-5288
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About
Contact & Profiles
Research Areas
  • Total Knee Arthroplasty Outcomes
  • Knee injuries and reconstruction techniques
  • Shoulder Injury and Treatment
  • Transplantation: Methods and Outcomes
  • Bone fractures and treatments
  • Indigenous Studies and Ecology
  • Shoulder and Clavicle Injuries
  • Orthopedic Surgery and Rehabilitation
  • Neonatal Respiratory Health Research
  • Sports injuries and prevention
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Medical Imaging and Pathology Studies
  • Renal cell carcinoma treatment
  • Orthopaedic implants and arthroplasty
  • Neurogenetic and Muscular Disorders Research
  • Orthopedic Infections and Treatments
  • Calcium signaling and nucleotide metabolism
  • Aquaculture disease management and microbiota
  • Barrier Structure and Function Studies
  • Nerve Injury and Rehabilitation
  • Canadian Identity and History
  • Cellular transport and secretion
  • Genetic and Kidney Cyst Diseases
  • Organ Transplantation Techniques and Outcomes
  • Wine Industry and Tourism

Brigham and Women's Hospital
2015-2025

Harvard University
2002-2025

Boston Children's Hospital
1992-2025

Alaska Heart and Vascular Institute
2024

Memorial University of Newfoundland
1974-2016

Cambridge University Press
2016

University of Rochester Medical Center
2014

University of Mary Washington
2013

Cornell University
2013

Institute for Legal Studies
2013

Athletes, particularly those who are involved in sporting activ ities requiring repetitive overhead use of the arm (for example, tennis players, swimmers, baseball pitchers, and quarterbacks), may develop a painful shoulder. This is often due to impinge ment vulnerable avascular region supraspinatus biceps tendons. With passage time, degeneration tears rotator cuff result. Pathologically, syndrome has been classified into Stage I (edema hemor rhage), II (fibrosis tendonitis), III (tendon...

10.1177/036354658000800302 article EN The American Journal of Sports Medicine 1980-05-01

This investigation utilized gross dissections, histolog ical preparations, and neurophysiologic experiments to gain an improved understanding of the innervation human knee. Anatomical illustrations represent findings dissections 15 fresh amputation specimens. Neurohistologic preparations using silver staining techniques demonstrate rich soft tissues knee, a variety spe cialized receptors are identified. In 10 subjects with normal knees, experimentally produced knee ef fusion 60 cc was found...

10.1177/036354658201000601 article EN The American Journal of Sports Medicine 1982-11-01

Imbalance of the internal and external rotator muscu lature shoulder, excess capsular laxity, loss flexibility, have all been implicated as etio logic factors in glenohumeral instability impinge ment syndrome; however, these assertions are based largely on qualitative clinical observations. In order to quantitatively define requirements adequate pro tective synergy musculature, well primary capsulolabral re straints, we prospectively evaluated 53 subjects: 15 asymptomatic volunteers, 28...

10.1177/036354659001800406 article EN The American Journal of Sports Medicine 1990-07-01

In a biomechanical and morphological study of cadaver knees clinical end-result fifty patients with tears the anterior cruciate ligament, structure function mechanism injury, results various forms therapy were analyzed. It was concluded that tension ligament varies during knee motion, being least at from 40 to 50 degrees flexion; there are adequate intraligamentous blood vessels nerves for healing occur; isolated do occur (probably as result internal-rotation displacement tibia respect...

10.2106/00004623-197456020-00001 article EN Journal of Bone and Joint Surgery 1974-03-01

10.2106/00004623-196345050-00001 article EN Journal of Bone and Joint Surgery 1963-07-01

Qualitative visual inspection and manual muscle testing are traditional methods of evaluation that may overlook subtle weakness the axioscapular musculature. A modification standard technique Moiré topographic analysis spinal deformity was applied to assess function in 51 subjects: 22 asymptomatic individuals, with shoulder instability, seven impingement syndrome. Static demonstrated scapulothoracic asymmetry or increased topography 14% subjects, compared 32% 57% instability groups,...

10.1097/00003086-199212000-00024 article EN Clinical Orthopaedics and Related Research 1992-12-01

Our clinical stress machine serves as an additional aid in the detection of isolated or combined damage to ligamentous structures about knee. The has greatly assisted classification chronic damage. In questionable gray area medial instability, evaluation been a great asset making critical therapeutic decisions.

10.2106/00004623-197153070-00001 article EN Journal of Bone and Joint Surgery 1971-10-01

For years there has been a struggle for satisfactory intraar ticular replacement in the anterior cruciate-deficient knee. This paper summarizes our basic and clinical research over last decade presents potential solution to problem. Instron testing reveals that cruciate ligament fails at 51.2 kg. Scanning electron microscopy demonstrates is little difference whether tested just point of failure or taken visible rupture. The technique MacIntosh quadriceps-patellar tendon transfer outlined....

10.1177/036354658000800101 article EN The American Journal of Sports Medicine 1980-01-01

The Journal of Trauma: Injury, Infection, and Critical Care: May 1967 - Volume 7 Issue 3 p 367-377

10.1097/00005373-196705000-00004 article EN Journal of Trauma and Acute Care Surgery 1967-05-01

Our experience with the Ellison procedure for control of anterior subluxation lateral tibial plateau includes fifty-two knees in which we used this either alone or combination other reconstructive procedures. The results directly attributable to itself after follow-ups six months more could be evaluated fifteen patients who had only anterolateral instability and thirteen both a pes anserinus transfer combined anteromedial instability. Of twenty-eight so evaluated, sixteen (57 per cent) good...

10.2106/00004623-197860080-00002 article EN Journal of Bone and Joint Surgery 1978-12-01

1. The importance of recognising osteochondral fractures the femoral condyle in adolescent knee joint is emphasised. 2. mechanism formation discussed. Essentially, a powerful rotary and compressive force shears off cartilage subchondral bone. absence lateral condylar lesions experimental group lends support to theory that patella may cause fracture by impingement. 3. On basis clinical classification condyles presented. 4. Early surgery recommended. arguments for removal or replacement fragment are

10.1302/0301-620x.48b3.436 article EN Journal of Bone and Joint Surgery - British Volume 1966-08-01

1. Screw fixation of clavicle to coracoid process, with subsequent calcification and ossification along the conoid trapezoid ligaments, creates an extra-articular fusion acromio-clavicular joint. 2. Though follow-up is admittedly early, excellent results can be obtained in young healthy adult. It possible return athlete competitive sports a heavy labourer full work surprisingly short time. 3. The operation doubtful value older patients. 4. A precise operative technique most important...

10.1302/0301-620x.36b2.202 article EN Journal of Bone and Joint Surgery - British Volume 1954-05-01

Reconstruction of the knee with a chronic injury to anterior cruciate ligament is an unsolved problem. Biologic graft substitutes have failed maintain stability in longer postreconstruction intervals. In attempt overcome limitations performance, synthetic materials been proposed augment biologic tissue. this study, 6-mm polypropylene braid Ligament Augmentation Device (LAD) possessing tensile strength 1500 N and excellent fatigue creep properties was investigated as adjunct...

10.1097/00003086-198506000-00025 article EN Clinical Orthopaedics and Related Research 1985-06-01

The purpose of this clinical retrospective study is to determine whether a polypropylene braid (PB) used augment an intraarticular autograft reconstruct the anterior cruciate ligament (ACL) safe and deter mine PB improves efficacy procedure. A simultaneous review was performed patients who had undergone ACL reconstruc tion using composed central quad riceps tendon, prepatellar periosteum, patellar ten don left attached distally tibial tubercle same procedure with augmentation autograft....

10.1177/036354658501300507 article EN The American Journal of Sports Medicine 1985-09-01

A defective intestinal epithelial tight junction (TJ) barrier has been proposed as an important pathogenic factor contributing to the inflammation of Crohn's disease. Glucocorticoids are first-line therapeutic agents for treatment moderate severe Glucocorticoid shown induce retightening TJ defect in disease patients. However, mechanisms that mediate glucocorticoid action on function remain unknown. The aim this study was elucidate mechanism modulation using vitro model system. Filter-grown...

10.1152/ajpgi.00252.2006 article EN AJP Gastrointestinal and Liver Physiology 2006-10-27

Mucolipidosis type IV (MLIV) is a lysosomal storage disorder caused by mutations in the MCOLN1 gene, member of transient receptor potential (TRP) cation channel gene family. The encoded protein, mucolipin-1 (TRPML1), has been localized to lysosomes and late endosomes but pathogenic mechanism which loss TRPML1 leads abnormal cellular neuronal cell death still poorly understood. Yeast two-hybrid co-immunoprecipitation (coIP) experiments identified interactions between Hsc70 as well Hsp40....

10.1002/jcp.21676 article EN Journal of Cellular Physiology 2008-12-30

10.1177/036354657800600602 article EN The American Journal of Sports Medicine 1978-11-01

In a retrospective study to determine whether the efficacy of intra-articular reconstruction anterior cruciate ligament is improved by an extra-articular transfer biceps femoris tendon, we compared results in group forty-three patients whom advancement procedure had been done with those fifty it not. The minimum length follow-up was twenty-four months. There no significant difference between two groups, and concluded that tendon does not improve ligament.

10.2106/00004623-198769020-00017 article EN Journal of Bone and Joint Surgery 1987-02-01

Mercury strain gauges were sutured onto the tibial collateral anterior and posterior cruciate ligaments to quantitatively determine relative or deformation of each these as a function joint position. The results obtained on 5 amputation specimens by subjecting them flexion, extension, rotation, valgus--varus anteroposterior forces. ligament is most lax in full flexion stretches with valgus external rotation. are at 35 degrees stretch both extension. Internal rotation varus ligament. These...

10.1097/00003086-197711000-00031 article EN Clinical Orthopaedics and Related Research 1977-11-01

Five patients developed paralysis to the sciatic nerve after application of a pneumatic tourniquet for knee ligament surgery. Four these made complete neurologic recovery within 6 months. A subsequent experimental investigation has demonstrated that some degree impaired function in dog occurs with every application. On basis this work, it is recommended not be left inflated periods longer than 1 hr and 15 min. In addition, suggested once been deflated during an operative procedure, should...

10.1177/036354658000800207 article EN The American Journal of Sports Medicine 1980-03-01
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