A5010391122- Visual perception and processing mechanisms
- Ophthalmology and Visual Impairment Studies
- Ophthalmology and Eye Disorders
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Cerebral Venous Sinus Thrombosis
- Intraocular Surgery and Lenses
- Pituitary Gland Disorders and Treatments
- Hallucinations in medical conditions
- Circadian rhythm and melatonin
- Neonatal and fetal brain pathology
- melanin and skin pigmentation
- Child Abuse and Related Trauma
- Craniofacial Disorders and Treatments
- Retinal Diseases and Treatments
- Tactile and Sensory Interactions
- Motor Control and Adaptation
- Vestibular and auditory disorders
- Corneal surgery and disorders
- Neurological disorders and treatments
- Connexins and lens biology
- Neurogenesis and neuroplasticity mechanisms
- Functional Brain Connectivity Studies
University College London
2009-2021
Moorfields Eye Hospital
2009-2021
International Council of Ophthalmology
2017
Moorfields Eye Hospital NHS Foundation Trust
1999-2015
National Health Service
2012
National Institute for Health Research
2012
NIHR Biomedical Research Centre at The Royal Marsden and the ICR
2012
Hospital Universitario Ramón y Cajal
2010
Museum of Military Medicine
2008
Hull and East Yorkshire Hospitals NHS Trust
2004
The axon initial segments of pyramidal cells and large small stellate in the primate sensori-motor cortex have a typical membrane undercoating bundles neurotubules. Those are directed towards white matter whereas those often run obliquely or cortical surface may be curved. Cisternal organs these related to symmetrical terminals, frequently coming into close apposition non-synaptic part terminals adjacent synapse between terminal segment. dense plates cisternal segment specifically stained by...
To investigate whether binocular information provides benefits for programming and guidance of reach-to-grasp movements in normal children these eye-hand coordination skills are impaired with amblyopia abnormal binocularity.Reach-to-grasp performance the preferred hand versus monocular (dominant or nondominant eye occluded) conditions to different objects (two sizes, three locations, two repetitions) was quantified by using a 3D motion-capture system. The participants were 36 (age, 5-11...
An experimental electron microscope (e.m.) study has been made of the termination afferent connections to primate sensori-motor cortex. Following large, stereotaxically placed thalamic lesions, degeneration in motor and somatic sensory cortices was studied at survival periods 4 5 days. Degenerating thalamocortical terminals had asymmetric membrane specializations. In cortex 89.5% synapses on dendritic spines, 9% shafts 1.5% cell somata; area 89% 11 % one example contacted a soma spine. A...
Gap junctions have been found infrequently between two dendrites or a dendrite and cell soma in the deep layers of both motor somatic sensory cortices primate. At these outer leaflets plasma membranes profiles are intimately apposed with gap 2 nm them which shows structure hexagonal subunits tangential sections. These occur mainly somata large stellate cells but also associated some examples dendro-dendritic synapse thus presynaptic dendrites; desmosome may association junction synapse....
<h3>Background</h3> Primary ciliary dyskinesia (PCD) is a rare, genetically heterogeneous ciliopathy disorder affecting cilia and sperm motility. A range of ultrastructural defects the axoneme underlie disease, which characterised by chronic respiratory symptoms obstructive lung infertility body axis laterality defects. We applied next-generation sequencing approach to identify gene responsible for this phenotype in two consanguineous families. <h3>Methods results</h3> Data from whole-exome...
To examine factors contributing to eye-hand coordination deficits in children with amblyopia and impaired stereovision.Participants were 55 anisometropic or strabismic aged 5.0 9.25 years different degrees of abnormal binocularity, along 28 age-matched visually-normal controls. Pilot data obtained from four additional patients studied longitudinally at treatment stages. Movements the preferred hand recorded using a 3D motion-capture system while subjects reached-to-precision grasp objects...
A study has been made of the neuronal somata in motor and somatic sensory cortices monkey. Pyramidal cells cortex are very similar to those described previously parietal cortical areas. The largest pyramidal area 4, Betz layer V, up 50 μm transverse diameter. Although basically resembling smaller cells, nucleus a cell often complex indentation is relation overall size soma than that pyramid cytoplasm contains discrete clumps endoplasmic reticulum. As with other synapses on all symmetrical...
The purpose of this study was to investigate current patterns management and outcomes intermittent distance exotropia [X(T)] in the UK. This an observational cohort which recruited 460 children aged < 12 years with previously untreated X(T). Eligible subjects were enrolled from 26 UK hospital ophthalmology clinics between May 2005 December 2006. Over a 2-year period follow-up, clinical data prospectively recorded at standard intervals enrolment. Data collected included angle, near...
Background To ascertain which countries in the world have retinopathy of prematurity (ROP) screening programmes and guidelines how these were developed. Methods An email database was created requests sent to ophthalmologists 141 nations complete an online survey on ROP their country. Results Representatives from 92/141 (65%) responded. 78/92 (85%) existing programmes, 68/78 (88%) defined criteria. Some limited those areas no or for there is inadequate knowledge are mainly Southeast Asia,...
Purpose.: During development, the presence of strabismus and anisometropia frequently leads to amblyopia, a visual disorder characterized by interocular acuity differences. Although additional deficits in contrast sensitivity, crowding (the impaired recognition closely spaced objects), stereoacuity are common, relationship between these abilities is unclear. Methods.: We measured covariation four children 4 9 years age (n = 72) with strabismus, anisometropia, or mixed...
Studies in nonhuman primates show that monocular visual deprivation starting at different ages has effects on cells the parvocellular and magnocellular laminae of lateral geniculate nucleus. The present study used color luminance contrast sensitivity (CS) measurements to look for differences parvocellular- magnocellular-related function human subjects with strabismic amblyopia.Fifteen early- 14 late-onset amblyopia similar ranges acuity were studied, together 15 normal vision. Contrast...
Dendro-dendritic synapses have been observed infrequently in the deep layers of motor cortex. The presynaptic dendrites are a varicose type and themselves receive considerable density both asymmetric symmetrical type. ultrastructure dendro-dendritic synapse itself shows typical arrangement postsynaptic membrane densities, often with dense projections, specialization is There usual cleft containing electron-dense material between profiles. synaptic vesicles occur small cluster confined to...
<h3>Aim:</h3> To investigate factors associated with early management of intermittent exotropia (X(T)) in hospital eye departments the UK a prospective cohort study. <h3>Methods:</h3> An inception 460 children aged <12 years previously untreated X(T) (mean age 3.6 years, 55.9% girls) was recruited from 26 children's clinics and orthoptic departments. Participants received standard ophthalmic examination at recruitment assessment three-monthly intervals thereafter. The influence severity...