A5037770131- Natural product bioactivities and synthesis
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Plant biochemistry and biosynthesis
- Phytochemicals and Antioxidant Activities
- Sesquiterpenes and Asteraceae Studies
- Biological Activity of Diterpenoids and Biflavonoids
- Wood Treatment and Properties
- Phytochemical compounds biological activities
- Phytochemical Studies and Bioactivities
- Lignin and Wood Chemistry
- Synthesis of Organic Compounds
- Carbohydrate Chemistry and Synthesis
- Traditional and Medicinal Uses of Annonaceae
- Natural Fiber Reinforced Composites
- Bee Products Chemical Analysis
- Wood and Agarwood Research
- Plant chemical constituents analysis
- Bioactive Compounds and Antitumor Agents
- Traditional Chinese Medicine Analysis
- Bioactive natural compounds
- Crystallization and Solubility Studies
- Forest Insect Ecology and Management
- X-ray Diffraction in Crystallography
- Polymer composites and self-healing
Université du Québec à Chicoutimi
2016-2025
Essence Line (Czechia)
2020
Boréa (Sweden)
2019
Université du Québec
2014
Université Laval
2008
Health Canada
2000
Université de Sherbrooke
1997
beta-caryophyllene is a sesquiterpene widely distributed in essential oils of various plants. Several biological activities are attributed to beta-caryophyllene, such as anti-inflammatory, antibiotic, antioxidant, anticarcinogenic and local anaesthetic activities. In this work, the potentiating effect on anticancer activity alpha-humulene, isocaryophyllene paclitaxel against MCF-7, DLD-1 L-929 human tumour cell lines was evaluated. A non-cytotoxic concentration significantly increased...
The antitumor activity of the essential oil Abies balsamea (balsam fir oil) was evaluated against several solid tumor cell lines including MCF-7, PC-3, A-549, DLD-1, M4BEU and CT-26. Balsam found to be active all tested, with GI50 values ranging between 0.76 1.7 mg/mL. analyzed by GC-MS cytotoxicity each constituent determined. is essentially constituted monoterpenes (&γτ; 96 %) some sesquiterpenes. All compounds tested were inactive 250 μM) except for α-humulene (GI50 = 55 73 which thus...
Ex vivo antioxidant, anti-inflammatory, anticancer and antibacterial activities of the essential oil from Tunisian Nigella sativa seeds its main terpenes (p-cymene, γ-terpinene, thymoquinone, β-pinene, carvacrol, terpinen-4-ol longifolene) were determined. The exhibited strong ex antioxidant activity, inhibiting DCFH oxidation with an IC50 1.0 µg/ml, high anti-inflammatory NO radical excretion value 6.3 µg/ml. Thymoquinone was found to be most active decrease excretion. significantly inhibit...
Background:Tanacetum vulgare L. (Asteraceae) is a perennial herb that has been used to treat multiple ailments. Regional variability of the chemical composition T. essential oils well-known. Despite these regional chemotypes, most relevant studies did not analyze complete oil and its constituents in relation their biological activities. Here, we assess anti-inflammatory, antioxidant, antibacterial, cytotoxic activities collected from northern Quebec (Saguenay-Lac-St-Jean), Canada. Methods:...
ABSTRACT Nigella sativa is a one of the most commonly found aromatics in Mediterranean kitchen. This plant traditionally used for treatment several pathologies. In this study, antioxidant, anti-inflammatory, anticancer and antibacterial activities shoots, roots seeds methanol extracts from N. were studied. The three organs exhibited strong antioxidant activity using oxygen radical absorbance capacity method cell-based assay. Furthermore, hexane fraction (SHF) extract showed significant...
The chemical compositions of eleven wild species aromatic and medicinal plants indigenous to Algeria, including Thymus, Mentha, Rosmarinus, Lavandula, Eucalyptus, were analyzed. identification the composition each oil was conducted using GC-FID GC-MS capillary gas chromatography. study investigated variability essential oils based on several parameters. These included impact vegetative cycle composition, variations among subspecies same species, within genus, influence environmental factors...
Abstract The antibacterial activity of the essential oil Abies balsamea (balsam fir) was evaluated against Escherichia coli and Staphylococcus aureus . A. found to be inactive E. (>100 µg/mL) active S. , with an MIC 56 µg/mL. composition analysed by GC‐MS each constituent determined. is essentially constituted monoterpenes (>96%) some sesquiterpenes. β ‐pinene (29.9%), δ ‐3‐carene (19.6%) α (14.6%) were major components. both bacteria strains. However, three constituents : ‐pinene,...
The naturally occurring cytotoxic saponin 28-O-β-d-glucopyranosylbetulinic acid 3β-O-α-l-arabinopyranoside (3) was easily synthesized along with seven bidesmosidic saponins starting from the lupane-type triterpenoids betulin (1) and betulinic (2). As highlighted by preliminary cytotoxicity evaluation against A549, DLD-1, MCF7, PC-3 human cancer cell lines, 22a, bearing α-l-rhamnopyranoside moieties at both C-3 C-28 positions, determined to be a potent agent (IC50 1.8−1.9 μM).
Antioxidant activity, inhibition of nitric oxide (NO) overproduction, and antiproliferative effect ethyl acetate extracts maple sap syrup from 30 producers were evaluated in regard to the period harvest three different regions Québec, Canada. Oxygen radical absorbance capacity (ORAC) values are, respectively, 12 ± 6 15 5 μmol Trolox equivalents (TE)/mg. The antioxidant activity was also confirmed by a cell-based assay. has no statistically significant incidence on both extracts. pure...
Brasenia schreberi Gmel. (Cabombaceae) is an aquatic plant that grows in eastern Asia, Australia, Africa, and North Central America. B. leaf extracts were obtained by sequential solvent extraction with dichloromethane, methanol, water. The antioxidant potential of each extract was assessed using the oxygen radical absorbance capacity (ORAC) assay. With this method, methanol water found to be active mean ± standard deviation values 7 2 5.1 0.5 μmol Trolox® equivalents (TE)/mg, respectively....
A visible-light-mediated chlorotrifluoromethylation catalyzed by a copper-based photo-redox catalyst of internal alkenes is reported. The reaction proceeds with complete regioselectivity under mild conditions using commercially available F3CSO2Cl as both the trifluoromethyl and chlorine source, leading to synthesis added-value chemicals atom-economy. vast array were functionalized in decent good yields, highlighting great tolerance various functional groups. radical process starting from...
The search for safer and more effective vaccine adjuvants has intensified in recent years, with triterpenoid saponins like QS‐21 its analogues emerging as promising candidates. We report the synthesis of a novel analogue featuring betulinic acid aglycone, lupane‐type low toxicity derived from white birch bark. Two convergent synthetic routes, involving different protecting groups glycosyl donors (bromide trichloroacetimidate), were optimized to construct QS‐21‐based linear trisaccharide...