A5109286577- Retinal Imaging and Analysis
- Blood Pressure and Hypertension Studies
- Cell Adhesion Molecules Research
- Cardiovascular Health and Disease Prevention
- Dialysis and Renal Disease Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nitric Oxide and Endothelin Effects
- Atherosclerosis and Cardiovascular Diseases
- Eicosanoids and Hypertension Pharmacology
- Renal and Vascular Pathologies
- Sirtuins and Resveratrol in Medicine
- Sodium Intake and Health
- Acute Ischemic Stroke Management
- Adipokines, Inflammation, and Metabolic Diseases
- Renal function and acid-base balance
- Vitamin C and Antioxidants Research
- Adipose Tissue and Metabolism
- Alcohol Consumption and Health Effects
- Advanced Glycation End Products research
- Hormonal Regulation and Hypertension
- Chronic Kidney Disease and Diabetes
- Hemodynamic Monitoring and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
University of Palermo
2013-2025
European Society of Hypertension
2018-2025
Azienda Ospedaliera di Padova
2008
University of Padua
2008
Istituto Neurologico Mediterraneo
1999
Background: Cardiorenal Syndrome (CRS) represents a growing global health challenge due to the increasing prevalence of coexisting kidney and heart disease. The complex pathophysiology CRS demands an integrated, multidisciplinary approach involving both nephrology cardiology. However, specialized care models remain limited, leading fragmented management suboptimal outcomes. Methods: A Kidney–Heart Outpatient Service was established at "Paolo Giaccone" University Hospital in Palermo May 2023...
The renal resistive index (RRI), a doppler ultrasound-derived parameter measuring vascular resistance, has emerged as promising non-invasive tool to evaluate haemodynamics in critically ill patients, particularly those with Acute Respiratory Distress Syndrome (ARDS) and heart failure (HF). This review examines the current evidence for RRI measurement these conditions, exploring its physiological bases, methodology, clinical applications, limitations. In ARDS, reflects complex interactions...
We determined the concentration of nitric oxide metabolites (NO2 − +NO3 ), expressed as NOx, in several clinical conditions. Regarding this, we have examined 25 subjects with arterial hypertension, 41 chronic kidney disease conserv
Background/Objectives: Isolated nocturnal hypertension (INH) represents a unique phenotype that can only be identified through ambulatory blood pressure monitoring (ABPM). An increasing body of evidence suggests significant association between INH and heightened cardiovascular morbidity, mortality, and, more recently, kidney disease progression. Considering these findings, this study aims to retrospectively assess the prevalence its relationship with glomerular filtration rate (GFR) albumin...
Background/Objectives: Considering the physiological analogies between eye and kidney, this study aimed to investigate potential relationship retinal vascular density, assessed using Optical Coherence Tomography Angiography (OCT-A), renal resistive index (RRI) in patients with arterial hypertension. Methods: A total of 82 hypertensive were enrolled study. Participants underwent routine biochemical evaluations, 24-hour ambulatory blood pressure monitoring, OCT-A imaging, Doppler ultrasound...
Everywhere, independently of the care setting, there is an urgent, unsatisfied need to take patients with combined kidney and heart disease. In May 2023 we launched Kidney-Heart Outpatient Service in Nephrology Dialysis Unit “Paolo Giaccone” University Hospital Palermo. The clinical mission our provide a coordinated, multi- disciplinary for non hospitalized coexisting disease, aim significantly reduce admissions readmissions hospital, improving patient outcomes optimizing utilization...
Background/Objectives: Considering the physiological analogies between eye and kidney, this study aimed to investigate potential relationship retinal vascular density, assessed using Optical Coherence Tomography Angiography (OCT-A), renal resistive index (RRI) in patients with arterial hypertension. Methods: A total of 82 hypertensive (mean age 48 ± 13) were enrolled study. Participants underwent routine biochemical evaluations, office-based blood pressure measurement, 24 h ambulatory...
8-iso-prostaglandin-F2α (8-iso-PGF2α) is a recognized marker of oxidative stress. Previous studies suggested that 8-iso-PGF2α plays an important role in the pathogenesis hypertension and cardiovascular (CV) diseases. However, limited data exist on prognostic hypertensive patients undergoing primary prevention. The aim this study was to assess relationship between 10-year CV risk, as predicted by validated equations without Materials methods. A total 432...
Objective: The objective was to assess the differences about prevalence of high blood pressure values in adolescents by applying 2016 ESH and 2017 AAP hypertension guidelines analyze relationship increases with lifestyles potentially risky behaviors, which Italy are little investigated. Design method: Blood levels 1301 students aged between 13 20 were recorded. Two questionnaires administered, one related anamnestic data anthropometric parameters a second one, combined measurement pressure,...
Background: 8-iso-prostaglandin-F2α (8-iso-PGF2α) is a recognized marker of oxidative stress. Previous studies suggested that 8-iso-PGF2α plays an important role in the pathogenesis hypertension and cardiovascular (CV) diseases. However, limited data exist on prognostic hypertensive patients undergoing primary prevention. The aim this study was to assess relationship between 10-year CV risk, as predicted by validated equations without Materials methods: A total 432 individuals aged 40–75...
Introduction: The American Academy of Pediatrics (AAP) published in 2017 new guidelines for the screening and management hypertension children containing different nomograms compared to European guidelines, leading a reclassification blood pressure values, consequences which are still little investigated. aim our study was evaluate prevalence high values estimated with both most recent analyze relationship increases lifestyles potentially risky behaviors school population Western Sicily....
Background: Acute kidney injury (AKI) has emerged as a significant complication in patients with coronavirus disease 2019 (COVID-19). The pathophysiology of COVID-19-associated AKI is multifactorial, involving both direct viral effects on renal cells and indirect mechanisms such systemic inflammation cytokine storms. This highlights the critical need for early detection effective management strategies to mitigate improve patient outcomes. aim our study assess potential predictive role...
In 1836, Richard Bright (1789–1858), the first of a series outstanding physician–pathologists at Guy’s Hospital in London, noted that both cardiac hypertrophy and dropsy were common patients with kidney disease [...]
Background: The eye and kidney share embryological, structural, pathophysiological similarities, suggesting potential interconnections between retinal renal microvascular changes. Hypertension, a major risk factor for impairment, also affects microvasculature. This study investigates the relationship vascular density, assessed by Optical Coherence Tomography Angiography (OCT-A), early dysfunction in hypertensive patients. Methods: A total of 142 patients (mean age 47 ± 13 years; 74% male)...
Background: The neutrophil-to-lymphocyte ratio (NLR) has emerged as a readily available marker of systemic inflammation and immune dysregulation. In patients undergoing hemodialysis, is known contributor to erythropoietin resistance. However, the relationship between NLR resistance index (ERI) not been extensively characterized. Methods: A total 317 hemodialysis were retrospectively evaluated stratified into tertiles based on levels. Biochemical, inflammatory, anthropometric variables...
Objective: To compare cardiovascular risk in white-coat hypertensives, normotensives and established hypertensives. Methods: We studied 61 hypertensive individuals, 27 of whom were 35 normotensives. All subjects underwent 24 h noninvasive blood pressure monitoring Doppler echocardiographic examination the heart; urine was tested for microalbuminuria fundi eyes examined retinopathy. Results: The as well day- night-time mean systolic (SBP) slightly but significantly higher hypertensives than...