A5045292555- Blood properties and coagulation
- Adipokines, Inflammation, and Metabolic Diseases
- Venous Thromboembolism Diagnosis and Management
- Erythrocyte Function and Pathophysiology
- Obstructive Sleep Apnea Research
- Exercise and Physiological Responses
- Cardiovascular and exercise physiology
- Atherosclerosis and Cardiovascular Diseases
- Cell Adhesion Molecules Research
- Diabetes and associated disorders
- Diagnosis and Treatment of Venous Diseases
- Advanced Glycation End Products research
- Cardiovascular Function and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Disease Prevention
- Muscle metabolism and nutrition
- Acute Myocardial Infarction Research
- Neuroscience of respiration and sleep
- Acute Ischemic Stroke Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiovascular and Diving-Related Complications
- Fatty Acid Research and Health
- Vitamin C and Antioxidants Research
- Antioxidant Activity and Oxidative Stress
- Blood Coagulation and Thrombosis Mechanisms
University of Palermo
2013-2023
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo
2020
Istituto di Fisiologia Clinica
1999
Our aim was to examine some parameters of oxidative status, gelatinases, and their inhibitors evaluate interrelationships in subjects with metabolic syndrome (MS). We enrolled 65 MS subjects, subdivided according the presence or not diabetes mellitus. examined lipid peroxidation (expressed as thiobarbituric acid reacting substances, TBARS), protein oxidation carbonyl groups), nitric oxide metabolites (NO x ), total antioxidant status (TAS), MMP-2, MMP-9, TIMP-1, TIMP-2. found that diabetics...
The aim of our study was to evaluate the associations between arterial stiffness indexes and immune-inflammatory markers in subjects with acute ischemic stroke without metabolic syndrome.We enrolled 130 patients syndrome, 127 syndrome 120 control stroke. Applanation tonometry used record augmentation index (Aix) pulse wave velocity (PWV). We also evaluated plasma levels C-reactive protein (CRP), Interleukin-1beta (IL-1β), tumor necrosis factor-alpha (TNF-α), Interleukin-6 (IL-6)...
We determined the concentration of nitric oxide metabolites (NO2 − +NO3 ), expressed as NOx, in several clinical conditions. Regarding this, we have examined 25 subjects with arterial hypertension, 41 chronic kidney disease conserv
Obstructive sleep apnea syndrome (OSAS) is associated with an elevated risk of cardiovascular events and stroke. Matrix metalloproteinases (MMPs) are endopeptidases involved in extracellular matrix degradation then the development progression diseases. Our aim was to evaluate plasma levels gelatinases (MMP-2 MMP-9) their tissue inhibitors (TIMP-1 TIMP-2) a group subjects OSAS. We enrolled 48 (36 men 12 women; mean age 49.7 ± 14.68 yrs) OSAS diagnosed 1-night cardiorespiratory study we...
Our aim was to evaluate lipid peroxidation, expressed as thiobarbituric acid-reactive substances (TBARS), nitric oxide metabolites (nitrite + nitrate) as<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mrow><mml:mtext>NO</mml:mtext></mml:mrow><mml:mrow><mml:mi>x</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>, and TBARS/<mml:math...
In the last years neutrophil to lymphocyte ratio (NLR) has been examined in cardiovascular disorders and particular coronary artery disease acute myocardial infarction (AMI). Now we this parameter subjects with juvenile at initial stage after 3 12 months. We enrolled 123 young (112 men 11 women, mean age 39.4 ± 5.8 yrs) AMI. The time interval between AMI onset investigation was 13 7 days. value of NLR observed significantly increased compared normal controls (N = 1.817 0.711; 2.376 0.873, p...
Abstract Background The use of short geriatric tools in the emergency department (ED) is increasing, but literature still conflicting. aim this study to compare precision and accuracy two assessment predict mortality a cohort older patients attending ED. Methods A retrospective was conducted including ≥ 65 years, ED transferred medical unit from February July 2022. Clinical Frailty Scale (CFS) Brief Multidimensional Prognostic Index (Brief MPI) were administered. association between MPI CFS...
We examined lipid peroxidation, expressed as thiobarbituric acid-reactive substances (TBARS) and total antioxidant status (TAS) before after a cardiopulmonary test, in 20 sedentary controls 62 unprofessional male athletes subdivided into 3 subgroups. The first included subjects who practised endurance sports (14 cyclists 9 swimmers), the second mixed (6 basket players, 6 judoists, 8 water polo players) third group power (3 sprint runners, 4 weightlifters, 12 swimmers). In whole of an...
Venous leg ulcers are common in subjects with chronic venous insufficiency. The increased intraluminal pressure causes alteration of the skin microcirculation, leukocyte activation and release proteolytic enzymes leading to ulceration. An impaired expression activity matrix metalloproteases (MMPs) their tissue inhibitors (TIMPs) might influence extracellular degradation deposition failure healing process. Our aim was evaluate plasma concentration gelatinases (MMP-2 MMP-9) (TIMP-1 TIMP-2)...
Acute myocardial infarction (AMI) is accompanied by oxidative stress, and protein oxidation among the consequences of stress. We examined plasma concentration carbonyl groups (PC), a marker oxidation, in group young subjects with AMI (45 men 5 women; mean age 40.4 ± 4.8 yrs). found significant increase PC (p < 0.001) comparison normal controls. No difference was observed between patients characterized elevated ST segment those without elevation segment. There no correlation ejection fraction...
Our aim was to evaluate nitric oxide metabolites (nitrite and nitrate), expressed as NOx, erythrocyte deformability, elongation index, in a group of subjects with obstructive sleep apnea syndrome (OSAS). We enrolled 48 (36 men 12 women; mean age 50.3±14.68 yrs) OSAS diagnosed after 1-night cardiorespiratory study. severity assessed evaluating the apnea/hypopnea index (AHI) were subdivided two subgroups: Low (L=AHI<30) High (H=AHI>30). NOx examined converting nitrate into nitrite reductase...
Abstract The association between obesity and cardiovascular diseases has a multifactorial pathogenesis, including the synthesis of inflammatory molecules, increase in oxidative stress dysregulation matrix metalloprotease (MMP) concentration activity. In group adults with obesity, divided 2 subgroups according to body mass index (BMI), we examined lipid peroxidation, expressed as thiobarbituric acid-reactive substances (TBARS), protein oxidation, carbonyl groups (PCs), plasma gelatinases...
Considering the role of hemorheology in coronary circulation, we studied blood viscosity patients with juvenile myocardial infarction. We examined whole at high shear rate using cone-on-plate viscosimeter Wells-Brookfield ½ LVT and low employing a viscometer Contraves LS30 120 (aged <46 years) infarction, initial stage subsequently 3 12 months after. At stage, had an increased comparison to normal controls. This hemorheological profile was not influenced by cardiovascular risk factors,...
The goal of this research was to evaluate the plasma concentration MMP-9 and its tissue inhibitor (TIMP-1) in different clinical conditions. It included several groups subjects: 31 overweight subjects; 91 obese adults divided into two subgroups according BMI value (BMI 30-35 Kg/m2 > 35 Kg/m2); 90 subjects with metabolic syndrome (MS) (with without diabetes mellitus); 100 preclinical carotid atherosclerosis (PCA) number cardiovascular risk factors insulin resistance degree; 48 obstructive...