A5064594791- Acute Lymphoblastic Leukemia research
- Prenatal Screening and Diagnostics
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Acute Myeloid Leukemia Research
- Reproductive Health and Technologies
- Cancer-related gene regulation
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Chronic Myeloid Leukemia Treatments
- Biochemical and Molecular Research
- Epigenetics and DNA Methylation
- Ocular Oncology and Treatments
- Corneal Surgery and Treatments
- HIV/AIDS drug development and treatment
- Gestational Diabetes Research and Management
- Reproductive Physiology in Livestock
- Estrogen and related hormone effects
- Pregnancy and preeclampsia studies
- Paraoxonase enzyme and polymorphisms
- Neurofibromatosis and Schwannoma Cases
- Creativity in Education and Neuroscience
- Mind wandering and attention
- Kruppel-like factors research
University Medical Center Groningen
2006-2025
University of Groningen
2015-2025
Erasmus MC - Sophia Children’s Hospital
2007-2013
Erasmus MC
2009-2010
Leiden University Medical Center
2006
Abstract Lifestyle has been associated with in vitro fertilisation (IVF) success rates, but studies on diet and IVF outcomes are inconclusive. We studied associations between adherence to the Dutch guidelines for a Healthy 2015 pregnancy chances among women receiving modified natural cycle (MNC-IVF). This prospective cohort study utilised data from 109 undergoing MNC-IVF 2014 2018 at University Medical Centre Groningen enrolled examining metabolic profile of follicular fluid oocyte quality....
The aim of this study was to determine whether BRCA1/2 mutation carriers produce fewer mature oocytes after ovarian stimulation for in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD), comparison a PGD control group.A retrospective, international, multicenter cohort performed on data first cycles between January 2006 and September 2015. Data were extracted from medical files. one center three affiliated IVF centers the Netherlands Belgium. Exposed couples underwent...
One of the most frequently applied methods to study abnormal cognition is Continuous Performance Task (CPT). It unclear, however, which cognitive functions are engaged in normal CPT performance. The aims present were identify neurocognitive main variants and determine what extent these differentially engage functions. We hypothesized that versions (CPT-X, CPT-AX, CPT-Identical Pairs) can be distinguished by whether they demand sustained or transient attention response preparation. Transient...
Are bile acids (BA) and their respective subspecies present in human follicular fluid (FF) do they relate to embryo quality modified natural cycle IVF (MNC-IVF)?BA concentrations are 2-fold higher than serum ursodeoxycholic acid (UDCA) derivatives were associated with development of top embryos on Day 3 after fertilization.Granulosa cells capable synthesizing BA, but a potential correlation oocyte as well information the presence role BA have yet be investigated.Between January 2001 June...
Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder that affects the skin and nervous system. The condition completely penetrant with extreme clinical variability, resulting in unpredictable manifestations affected offspring, complicating reproductive decision-making. One of options to prevent birth offspring preimplantation genetic testing (PGT). We performed a retrospective review medical files all couples (n = 140) referred Dutch PGT expert center indication NF1 between...
Translocation of the LYL1 oncogene are rare in T-cell acute lymphoblastic leukemia, whereas homologous TAL1 gene is rearranged approximately 20% patients. Previous gene-expression studies have identified an immature leukemia subgroup with high expression absence chromosomal aberrations. Molecular characterization a t(7;19)(q34;p13) pediatric patient led to identification translocation between TRB@ and loci. Similar incidental cases synergistic, double translocations affecting TAL1/2 LMO1/2...
We aim to evaluate the safety of PGD. focus on congenital malformation rate and additionally report adverse perinatal outcome.We collated data from a large group singletons multiples born after PGD between 1995 2014. Data rates in live children terminated pregnancies, misdiagnosis rate, birth parameters, mortality, hospital admissions were prospectively collected by questionnaires.Four hundred thirty-nine pregnancies 381 women resulted 364 children. Nine (2.5%) had major malformations. This...
Abstract STUDY QUESTION Are levels of trimethylamine-N-oxide (TMAO) in human follicular fluid (FF) related to IVF outcomes? SUMMARY ANSWER Higher TMAO are a negative predictor oocyte fertilization and embryo quality. WHAT IS KNOWN ALREADY is metabolic product dietary choline l-carnitine produced via subsequent enzymatic modifications by the intestinal microbiota hepatocytes. promotes inflammatory oxidative stress pathways has been characterized as causative biomarker for development...
Abstract High density lipoproteins (HDL) are the main cholesterol carriers in follicular fluid (FF), natural environment of oocyte development. Additionally, HDL have critical biological functions such as anti-oxidative capacity, which not been studied reproduction. Therefore, this study aimed to investigate whether function FF-HDL is associated with fertility outcomes. From 253 women undergoing modified cycle (MNC)- IVF at a single academic centre FF and plasma were collected (n = 375...
Abstract Study question What are the reproductive outcomes observed of patients who cryopreserved oocytes or embryos in context fertility preservation Netherlands? Summary answer After 10 years follow-up, 25.5% women used their to attempt pregnancy and these, 34.6% had a live birth. is known already Fertility through freezing an established treatment for with risk premature ovarian failure (caused by benign oncological disease) physiological age-related decline. Little about success...
What are the reproductive outcomes of patients who cryopreserved oocytes or embryos in context fertility preservation Netherlands?
Is a thin endometrial lining before ovulation triggering more prevalent in patients utilizing preimplantation genetic testing for monogenic disease (PGT-M) compared to the regular IVF/ICSI population and is this associated with prior hormonal contraceptive use?Thin (<8 mm) PGT-M both longer use shorter cessation interval of contraceptives treatment.Thin has been lower pregnancy rates cycles increased chances miscarriage low birth weight. Endometrial thinning atrophy occur during use....