A5086343289- Chronic Obstructive Pulmonary Disease (COPD) Research
- Obstructive Sleep Apnea Research
- Lung Cancer Treatments and Mutations
- Neuroscience of respiration and sleep
- Fatty Acid Research and Health
- Gastric Cancer Management and Outcomes
- Maternal and fetal healthcare
- Lung Cancer Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Emergency and Acute Care Studies
- Air Quality and Health Impacts
- Heart Rate Variability and Autonomic Control
- Blood donation and transfusion practices
- Smoking Behavior and Cessation
- Food Security and Health in Diverse Populations
- Colorectal Cancer Treatments and Studies
- Hematological disorders and diagnostics
- Intraperitoneal and Appendiceal Malignancies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Bone and Joint Diseases
- Cardiovascular Issues in Pregnancy
- Maternal and Perinatal Health Interventions
- High Altitude and Hypoxia
- Inflammatory Myopathies and Dermatomyositis
- Pancreatic and Hepatic Oncology Research
Wake Forest University
2025
University of Miami
2022-2024
Miami VA Healthcare System
2022-2023
Johnston Memorial Hospital
2023
New Mexico Highlands University
2023
Johns Hopkins University
2018-2022
Johns Hopkins Medicine
2018-2022
Centre for Drug Research and Development
2021
University of Illinois Chicago
2016-2018
International Center for Research on Women
2017
Rationale: Higher indoor particulate matter (PM) concentrations are linked with increased asthma morbidity. Dietary intake of fatty acids, also outcomes, may influence this relationship. Objectives: To determine the relationship between omega-3 and omega-6 acid pediatric morbidity, association strength indoor, PM-related symptoms, albuterol use, systemic inflammation. Methods: Analyses included 135 children enrolled in AsthmaDIET Study. At baseline, 3 months, 6 data included: week-long...
On December 18, 2020, the FDA approved osimertinib as adjuvant therapy in patients with non-small cell lung cancer (NSCLC) whose tumors have EGFR exon 19 deletions or 21 (L858R) mutations, detected by an FDA-approved test. The approval was based on ADAURA study, which 682 NSCLC were randomized to receive (n = 339) placebo 343). Disease-free survival (DFS) overall population (stage IB-IIIA) improved for who received osimertinib, HR of 0.20; 95% confidence interval (CI), 0.15-0.27; P < 0.0001....
Omega-3 fatty acids, including alpha-linolenic acid (ALA), eicosapentaenoic (EPA), docosahexaenoic (DHA) and derivatives, play a key role in the resolution of inflammation. Higher intake has been linked to decreased morbidity several diseases, though effects on respiratory diseases like COPD are understudied. The National Health Nutrition Examination Survey (NHANES), with focus dietary assessment, provides unique opportunity explore relationships between omega-3 marked by inflammation United...
Summary Obstructive sleep apnea is associated with gestational hypertension. Elevated endothelin‐1 a proposed factor in the pathogenesis of However, association between and obstructive complicating pregnancy unknown. In prospective cohort 60 pregnant patients obesity but without confounding comorbid conditions (i.e. cardiac/pulmonary disease), plasma placental samples were collected at delivery 30 women without. Endothelin‐1 concentrations evaluated using Western blot, quantitative real‐time...
Background: The use of immune checkpoint inhibitor (ICI) therapy has improved outcomes for many types cancer, including primary lung cancer. With increased this therapy, immune-related adverse events (IRAE) are identified more frequently and can affect any organ system. ICI-pneumonitis varied levels severity at the time diagnosis that range from mild with nonspecific symptoms to fatal respiratory failure in severe cases. Therefore, early recognition is crucial, a multidisciplinary approach...
Abstract Introduction Obstructive sleep apnea (OSA) is a common disorder that underrecognized and associated with comorbid conditions societal impact. Health systems have directed efforts to inpatient assessment (OSA screening) identify patients at risk early treatment initiation avoid unexpected outcomes including medical emergency team activation (META) (code blue, code stroke, rapid response, reintubation). However, acceptance of positive airway pressure (PAP) therapy remains low for both...
Abstract Introduction Obstructive sleep apnea (OSA) is a common condition associated with multiple co-morbidities, however, diagnostic challenges limit its recognition. Sleep screening has improved our recognition, and Home Apnea Testing (HSAT) access to testing for OSA. The SANSA© device an FDA cleared novel HSAT patch that records 8 essential physiologic parameters (pulse oximetry, actigraphy, ECG-based heart rate rhythm, respiratory effort, chest movement, snoring, body position)...
Abstract Study Objectives Sleep is an important dimension in the care of chronic obstructive pulmonary disease (COPD), but its relevance to exacerbations unclear. We wanted assess whether sleep quality as measured by Pittsburgh Quality Index (PSQI) associated with increased risk COPD and does this differ socio-environmental exposures. Methods included 1647 current former smokers spirometrically confirmed from SPIROMICS cohort. assessed incidence rate ratios for exacerbation using...
The association of in-hospital medical emergency team activation (META) among patients with atrial fibrillation (AF) at risk for obstructive sleep apnea (OSA) is unclear. This study evaluates the performance DOISNORE50 questionnaire as an OSA screener AF and determines prevalence META perioperative underlying who have a diagnosis or are OSA.
Rationale: Ambient air pollution exposure is associated with respiratory morbidity among individuals chronic obstructive pulmonary disease (COPD), particularly those concomitant obesity. Although people COPD report high incidence of poor sleep quality, no studies have evaluated
<b>Objective</b> The objective of this study was to compare severe morbidity due obstetrical hemorrhage and its potential preventability before after a mandated provider training initiative on obstetric hemorrhage. <b>Study Design</b> Cases during 2006 (<i>n</i> = 64 initiative) 2010 71 were identified by two-factor scoring system intensive care unit admission and/or transfusion ≥ 3 units blood products reviewed an expert panel. Preventable factors categorized as provider, system, patient...
Nicotine from cigarette smoke is a biologically active molecule that has pleiotropic effects in the airway, which could play role smoking-induced lung disease. However, whether nicotine and its metabolites reach sustained, physiologically relevant concentrations on airway surfaces of smokers not well defined. To address these issues, nicotine, cotinine, hydroxycotinine were measured by mass spectrometry (MS) supernatants induced sputum obtained participants subpopulations intermediate...
The SubPopulations and InteRmediate Outcome Measures in COPD Study (SPIROMICS) is a prospective cohort study that enrolled 2981 participants with the goal of identifying new chronic obstructive pulmonary disease (COPD) subgroups intermediate markers progression. Individuals sleep apnea (OSA) experience impaired quality life more frequent exacerbations. severity also associates computed tomography scan-based emphysema alterations airway dimensions.
Postpartum haemorrhage (PPH) is an obstetric emergency caused by excessive blood loss after delivery, which the leading cause of maternal mortality worldwide. PPH can lead to volume depletion, hypovolemic shock, anaemia and ultimately death. The prevalence disproportionately higher in low resource settings where there limited access skilled medical care safe supplies. Current management strategies target both prevention treatment however no alternatives currently exist address lack supplies...
Omega-3 polyunsaturated fatty acids (PUFAs) have been associated with systemic anti-inflammatory responses. Dietary intake of omega-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) has also lower chronic obstructive pulmonary disease (COPD) morbidity using self-report food frequency questionnaires.
Journal Article Corrected proof Medical emergency team activation and cost reduction in cardiovascular surgery nonsurgical patients: DOISNORE50 sleep protocol Get access Kang Rui Xiang, Xiang Section of Pulmonary, Critical Care, Allergy Immunologic Diseases, Department Internal Medicine, Wake Forest University School Winston Salem, NC, USA Search for other works by this author on: Oxford Academic Google Scholar Kristin N Sheehan, Sheehan Amit K Saha, Saha Anesthesiology, Abigail L Koch, Koch...
Background: Healthcare costs in patients with COPD are rising increasing disease severity. This study investigates the role of comorbidities and symptoms as additional drivers based on data from COSYCONET cohort.